Basal forebrain atrophy along the Alzheimer's disease continuum in adults with Down syndrome

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• dc.contributor.author Aranha, Mateus Rozalem
• dc.contributor.author González-Ortiz, Sofía
• dc.contributor.author Fortea, Juan
• dc.date.accessioned 2024-09-27T06:20:44Z
• dc.date.available 2024-09-27T06:20:44Z
• dc.date.issued 2023
• dc.description.abstract Background: Basal forebrain (BF) degeneration occurs in Down syndrome (DS)-associated Alzheimer's disease (AD). However, the dynamics of BF atrophy with age and disease progression, its impact on cognition, and its relationship with AD biomarkers have not been studied in DS. Methods: We included 234 adults with DS (150 asymptomatic, 38 prodromal AD, and 46 AD dementia) and 147 euploid controls. BF volumes were extracted from T-weighted magnetic resonance images using a stereotactic atlas in SPM12. We assessed BF volume changes with age and along the clinical AD continuum and their relationship to cognitive performance, cerebrospinal fluid (CSF) and plasma amyloid/tau/neurodegeneration biomarkers, and hippocampal volume. Results: In DS, BF volumes decreased with age and along the clinical AD continuum and significantly correlated with amyloid, tau, and neurofilament light chain changes in CSF and plasma, hippocampal volume, and cognitive performance. Discussion: BF atrophy is a potentially valuable neuroimaging biomarker of AD-related cholinergic neurodegeneration in DS.
• dc.format.mimetype application/pdf
• dc.identifier.citation Rozalem Aranha M, Iulita MF, Montal V, Pegueroles J, Bejanin A, Vaqué-Alcázar L, et al. Basal forebrain atrophy along the Alzheimer's disease continuum in adults with Down syndrome. Alzheimers Dement. 2023 Nov;19(11):4817-27. DOI: 10.1002/alz.12999
• dc.identifier.doi http://dx.doi.org/10.1002/alz.12999
• dc.identifier.issn 1552-5260
• dc.identifier.uri http://hdl.handle.net/10230/61249
• dc.language.iso eng
• dc.publisher Elsevier
• dc.relation.ispartof Alzheimers Dement. 2023 Nov;19(11):4817-27
• dc.rights © 2023 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
• dc.subject.keyword Alzheimer's disease
• dc.subject.keyword Down syndrome
• dc.subject.keyword Basal forebrain
• dc.subject.keyword Biomarkers
• dc.subject.keyword Cholinergic
• dc.subject.keyword Magnetic resonance imaging
• dc.subject.keyword Neuroimaging
• dc.subject.keyword Volumetry
• dc.title Basal forebrain atrophy along the Alzheimer's disease continuum in adults with Down syndrome
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion