The association between air pollutants and hippocampal volume from magnetic resonance imaging: A systematic review and meta-analysis
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- dc.contributor.author Balboni, Erica
- dc.contributor.author Filippini, Tommaso
- dc.contributor.author Crous-Bou, Marta
- dc.contributor.author Guxens Junyent, Mònica
- dc.contributor.author Erickson, Lance D.
- dc.contributor.author Vinceti, Marco
- dc.date.accessioned 2022-05-18T05:34:52Z
- dc.date.available 2022-05-18T05:34:52Z
- dc.date.issued 2022
- dc.description.abstract Growing epidemiological evidence suggests that air pollution may increase the risk of cognitive decline and neurodegenerative disease. A hallmark of neurodegeneration and an important diagnostic biomarker is volume reduction of a key brain structure, the hippocampus. We aimed to investigate the possibility that outdoor air nitrogen dioxide (NO2) and particulate matter with diameter ≤2.5 μm (PM2.5) and ≤10 μm (PM10) adversely affect hippocampal volume, through a meta-analysis. We considered studies that assessed the relation between outdoor air pollution and hippocampal volume by structural magnetic resonance imaging in adults and children, searching in Pubmed and Scopus databases from inception through July 13, 2021. For inclusion, studies had to report the correlation coefficient along with its standard error or 95% confidence interval (CI) between air pollutant exposure and hippocampal volume, to use standard space for neuroimages, and to consider at least age, sex and intracranial volume as covariates or effect modifiers. We meta-analyzed the data with a random-effects model, considering separately adult and child populations. We retrieved four eligible studies in adults and two in children. In adults, the pooled summary β regression coefficients of the association of PM2.5, PM10 and NO2 with hippocampal volume showed respectively a stronger association (summary β -7.59, 95% CI -14.08 to -1.11), a weaker association (summary β -2.02, 95% CI -4.50 to 0.47), and no association (summary β -0.44, 95% CI -1.27 to 0.40). The two studies available for children, both carried out in preadolescents, did not show an association between PM2.5 and hippocampal volume. The inverse association between PM2.5 and hippocampal volume in adults appeared to be stronger at higher mean PM2.5 levels. Our results suggest that outdoor PM2.5 and less strongly PM10 could adversely affect hippocampal volume in adults, a phenomenon that may explain why air pollution has been related to memory loss, cognitive decline, and dementia.
- dc.format.mimetype application/pdf
- dc.identifier.citation Balboni E, Filippini T, Crous-Bou M, Guxens M, Erickson LD, Vinceti M. The association between air pollutants and hippocampal volume from magnetic resonance imaging: A systematic review and meta-analysis. Environ Res. 2022 Mar;204(Pt A):111976. DOI: 10.1016/j.envres.2021.111976
- dc.identifier.doi http://dx.doi.org/10.1016/j.envres.2021.111976
- dc.identifier.issn 0013-9351
- dc.identifier.uri http://hdl.handle.net/10230/53124
- dc.language.iso eng
- dc.publisher Elsevier
- dc.relation.ispartof Environ Res. 2022 Mar;204(Pt A):111976
- dc.rights © 2021 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
- dc.subject.keyword Hippocampal volume
- dc.subject.keyword Magnetic resonance imaging
- dc.subject.keyword Neuroimaging
- dc.subject.keyword Nitrogen dioxide
- dc.subject.keyword Particulate matter
- dc.title The association between air pollutants and hippocampal volume from magnetic resonance imaging: A systematic review and meta-analysis
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion