Crypt4GH: a file format standard enabling native access to encrypted data
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- dc.contributor.author Senf, Alexander
- dc.contributor.author Davies, Robert
- dc.contributor.author Haziza, Frédéric
- dc.contributor.author Marshall, John
- dc.contributor.author Troncoso-Pastoriza, Juan
- dc.contributor.author Hofmann, Oliver
- dc.contributor.author Keane, Thomas M.
- dc.date.accessioned 2022-04-25T12:28:15Z
- dc.date.available 2022-04-25T12:28:15Z
- dc.date.issued 2021
- dc.description.abstract Motivation: The majority of genome analysis tools and pipelines require data to be decrypted for access. This potentially leaves sensitive genetic data exposed, either because the unencrypted data is not removed after analysis, or because the data leaves traces on the permanent storage medium. Results: We defined a file container specification enabling direct byte-level compatible random access to encrypted genetic data stored in community standards such as SAM/BAM/CRAM/VCF/BCF. By standardizing this format, we show how it can be added as a native file format to genomic libraries, enabling direct analysis of encrypted data without the need to create a decrypted copy. Availability: The Crypt4GH specification can be found at: http://samtools.github.io/hts-specs/crypt4gh.pdf.
- dc.description.sponsorship This work was supported by the following grants: Wellcome (100956/Z/13/Z, 201535/Z/16/Z, 206194) [TMK, AS, RD], Strategic Focal Area “Personalized Health and Related Technologies (PHRT)” of the ETH Domain #2017-201 [JTP], European Joint Programme on Rare Diseases (EJP-RD) #825575 [FH], and NHMRC grant #1113531 and the Medical Research Future Fund [OH]
- dc.format.mimetype application/pdf
- dc.identifier.citation Senf A, Davies R, Haziza F, Marshall J, Troncoso-Pastoriza J, Hofmann O et al. Crypt4GH: a file format standard enabling native access to encrypted data. Bioinformatics. 2021 Feb 5;37(17):2753-2754. DOI: 10.1093/bioinformatics/btab087
- dc.identifier.doi http://dx.doi.org/10.1093/bioinformatics/btab087
- dc.identifier.issn 1367-4811
- dc.identifier.uri http://hdl.handle.net/10230/52885
- dc.language.iso eng
- dc.publisher Oxford University Press
- dc.rights © Alexander Senf et al. 2021. Published by Oxford University Press.This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri https://creativecommons.org/licenses/by/4.0/
- dc.subject.other Genètica -- Bases de dades
- dc.subject.other Genètica
- dc.subject.other Genòmica
- dc.title Crypt4GH: a file format standard enabling native access to encrypted data
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion