Epigenetic impact of a 1-week intensive multimodal group program for adolescents with multiple adverse childhood experiences

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• dc.contributor.author Kaliman, Perla
• dc.contributor.author Cosín Tomàs, Marta
• dc.contributor.author Madrid, Andy
• dc.contributor.author Roque López, Susana
• dc.contributor.author Llanez-Anaya, Elkin
• dc.contributor.author Papale, Ligia A.
• dc.contributor.author Alisch, Reid S.
• dc.contributor.author Davidson, Richard J.
• dc.date.accessioned 2022-12-22T08:31:56Z
• dc.date.available 2022-12-22T08:31:56Z
• dc.date.issued 2022
• dc.description.abstract Adverse childhood experiences (ACEs, i.e., abuse, neglect, household dysfunction) represent a potential risk factor for a wide range of long-lasting diseases and shorter life expectancy. We recently described a 1-week residential group program, based on mindfulness training, artistic expression and EMDR group therapy, that significantly reduced PTSD-related symptoms and increased attention/awareness-related outcomes in adolescent girls with multiple ACEs in a randomized controlled study. Since epigenetic mechanisms (i.e., DNA methylation) have been associated with the long-lasting effects of ACEs, the present report extends these prior findings by exploring genome-wide DNA methylation changes following the program. Saliva samples from all participants (n = 44) were collected and genomic DNA was extracted prior (T1) and following (T2) the intervention. Genome-wide DNA methylation analysis using the MethylationEPIC beadchip array (Illumina) revealed 49 differentially methylated loci (DML; p value < 0.001; methylation change > 10%) that were annotated to genes with roles in biological processes linked to early childhood adversity (i.e., neural, immune, and endocrine pathways, cancer and cardiovascular disease). DNA sequences flanking these DML showed significant enrichment of transcription factor binding sites involved in inflammation, cancer, cardiovascular disease, and brain development. Methylation changes in SIRT5 and TRAPPC2L genes showed associations with changes in trauma-related psychological measures. Results presented here suggest that this multimodal group program for adolescents with multiple victimization modulates the DNA methylome at sites of potential relevance for health and behavioral disorders associated with ACEs.
• dc.format.mimetype application/pdf
• dc.identifier.citation Kaliman P, Cosín-Tomás M, Madrid A, Roque López S, Llanez-Anaya E, Papale LA, Alisch RS, Davidson RJ. Epigenetic impact of a 1-week intensive multimodal group program for adolescents with multiple adverse childhood experiences. Sci Rep. 2022 Oct 20;12(1):17177. DOI: 10.1038/s41598-022-21246-9
• dc.identifier.doi http://dx.doi.org/10.1038/s41598-022-21246-9
• dc.identifier.issn 2045-2322
• dc.identifier.uri http://hdl.handle.net/10230/55213
• dc.language.iso eng
• dc.publisher Nature Research
• dc.relation.ispartof Sci Rep. 2022 Oct 20;12(1):17177
• dc.rights © The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Biomarkers
• dc.subject.keyword Health care
• dc.subject.keyword Psychology
• dc.title Epigenetic impact of a 1-week intensive multimodal group program for adolescents with multiple adverse childhood experiences
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion