Human Secretory IgM Emerges from Plasma Cells Clonally Related to Gut Memory B Cells and Targets Highly Diverse Commensals
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- dc.contributor.author Magri, Giuliana, 1978-ca
- dc.contributor.author Pybus Oliveras, Marc, 1985-ca
- dc.contributor.author Sintes, Jordica
- dc.contributor.author Lligé, Davidca
- dc.contributor.author Segura-Garzón, Danielca
- dc.contributor.author Bascones Gleave, Sabrina, 1985-ca
- dc.contributor.author Yeste, Adaca
- dc.contributor.author Grasset, Emilie K.ca
- dc.contributor.author Gutzeit, Cindyca
- dc.contributor.author Uzzan, Mathieuca
- dc.contributor.author Ramanujam, Meeraca
- dc.contributor.author van Zelm, Menno C.ca
- dc.contributor.author Albero-González, Raquelca
- dc.contributor.author Vazquez de las Heras, Ivonneca
- dc.contributor.author Iglesias, Marca
- dc.contributor.author Serrano Figueras, Sergica
- dc.contributor.author Márquez, Lucíaca
- dc.contributor.author Mercade, Elenaca
- dc.contributor.author Mehandru, Saurabhca
- dc.contributor.author Cerutti, Andrea, 1965-ca
- dc.date.accessioned 2018-06-05T09:11:41Z
- dc.date.available 2018-06-05T09:11:41Z
- dc.date.issued 2017
- dc.description.abstract Secretory immunoglobulin A (SIgA) enhances host-microbiota symbiosis, whereas SIgM remains poorly understood. We found that gut IgM+ plasma cells (PCs) were more abundant in humans than mice and clonally related to a large repertoire of memory IgM+ B cells disseminated throughout the intestine but rare in systemic lymphoid organs. In addition to sharing a gut-specific gene signature with memory IgA+ B cells, memory IgM+ B cells were related to some IgA+ clonotypes and switched to IgA in response to T cell-independent or T cell-dependent signals. These signals induced abundant IgM which, together with SIgM from clonally affiliated PCs, recognized mucus-embedded commensals. Bacteria recognized by human SIgM were dually coated by SIgA and showed increased richness and diversity compared to IgA-only-coated or uncoated bacteria. Thus, SIgM may emerge from pre-existing memory rather than newly activated naive IgM+ B cells and could help SIgA to anchor highly diverse commensal communities to mucus.
- dc.description.sponsorship Supported by European Advanced Grant (ERC-2011-ADG-20110310), MINECO (SAF2014-52483-R), AGAUR (2014 SGR 832), US NIH grants P01 AI61093, R01 AI57653, and U01 AI95613 (to A.C.), Boeringher Ingelheim grant 134564-2 (to A.C.), NIH grant R01 DK 112296-01 (to A.C. and S.M.), and Fondo de Investigación Sanitaria ISCIII fellowships CD14/00060 and CM13/00136 (to G.M. and L.C., respectively).
- dc.format.mimetype application/pdf
- dc.identifier.citation Magri G, Comerma L, Pybus M, Sintes J, Lligé D, Segura-Garzón D. et al. Human Secretory IgM Emerges from Plasma Cells Clonally Related to Gut Memory B Cells and Targets Highly Diverse Commensals. Immunity. 2017 Jul 18;47(1):118-134.e8. DOI: 10.1016/j.immuni.2017.06.013
- dc.identifier.doi http://dx.doi.org/10.1016/j.immuni.2017.06.013
- dc.identifier.issn 1074-7613
- dc.identifier.uri http://hdl.handle.net/10230/34830
- dc.language.iso eng
- dc.publisher Elsevierca
- dc.relation.ispartof Immunity. 2017 Jul 18;47(1):118-34
- dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/SAF2014-52483-R
- dc.rights © 2017 The Authors. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0
- dc.subject.keyword IgA
- dc.subject.keyword IgM
- dc.subject.keyword Gut
- dc.subject.keyword Human
- dc.subject.keyword Memory B cells
- dc.subject.keyword Microbiota
- dc.subject.keyword Mucosa
- dc.subject.keyword Plasma cells
- dc.subject.keyword Repertoire
- dc.subject.other Tracte gastrointestinal
- dc.subject.other Intestins--Microbiologia
- dc.title Human Secretory IgM Emerges from Plasma Cells Clonally Related to Gut Memory B Cells and Targets Highly Diverse Commensalsca
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion