Antibiotic-loaded bone cement is associated with a reduction of the risk of revision of total knee arthroplasty: Analysis of the Catalan Arthroplasty Register

Mostra el registre complet Registre parcial de l'ítem

  • dc.contributor.author Gil-Gonzalez, Sergi
  • dc.contributor.author Velasco-Regúlez, Borja
  • dc.contributor.author Cerquides, Jesus
  • dc.contributor.author Hinarejos Gómez, Pedro Angel
  • dc.contributor.author Monllau García, Juan Carlos
  • dc.contributor.author Pelfort López, Javier
  • dc.date.accessioned 2025-07-02T06:27:27Z
  • dc.date.available 2025-07-02T06:27:27Z
  • dc.date.issued 2025
  • dc.description.abstract Purpose: The purpose of this study was to analyse the impact on peri-prosthetic joint infection (PJI) rate and prosthetic survival using antibiotic-loaded bone cement (ALBC) versus plain cement during total knee arthroplasty (TKA). Methods: A retrospective cohort study was conducted. The main data source was the Catalan Arthroplasty Register (RACat). TKAs with surgery date between 1 January 2011 and 31 December 2020 were analysed and followed up until 31 December 2023. The main variable of interest was the type of cement (ALBC vs. plain cement), and several endpoints (septic revision, aseptic revision, and all-cause revision) were considered. The analysed outcomes were revision rates, survival rates and risk factors' hazard ratios (HR). Results: A total of 22,781 TKAs were analysed, 13,125 (57.6%) of them with plain cement and 9656 (42.4%) with ALBC. The septic revision rate was lower in the ALBC group after 3 months of follow-up (0.52% vs. 0.78%, p value = 0.04). Prosthetic survival with respect to the aseptic revision endpoint was also higher for the ALBC group during the whole follow-up period (~158 months). Regarding risk factors for infection, ALBC showed a protective effect, HR: 0.53 (0.44, 0.63), while sex (being male) and the analysed comorbidities increased the risk. Conclusions: ALBC is associated with a reduction in both the septic revision and the aseptic revision rate after TKA, and thus with higher prosthetic survival. Level of evidence: Level III, Therapeutic, retrospective.
  • dc.description.sponsorship This work was supported by the Ministerio de Ciencia e Innovación (projects PID2022-136787NB-I00 and PID2019-104156GB-I00), the European Commission H2020 program (grants 101060693, 101057693, 952026) and the Agència de Gestió d'Ajuts Universitaris i de Recerca (Award Number: 2020-18). None of the funding sources had a direct role in this work.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Gil-Gonzalez S, Velasco-Regúlez B, Cerquides J, Hinarejos P, Monllau JC, Pelfort X. Antibiotic-loaded bone cement is associated with a reduction of the risk of revision of total knee arthroplasty: Analysis of the Catalan Arthroplasty Register. Knee Surg Sports Traumatol Arthrosc. 2025 Jan;33(1):354-63. DOI: 10.1002/ksa.12361
  • dc.identifier.doi http://dx.doi.org/10.1002/ksa.12361
  • dc.identifier.issn 0942-2056
  • dc.identifier.uri http://hdl.handle.net/10230/70815
  • dc.language.iso eng
  • dc.publisher Wiley
  • dc.relation.ispartof Knee Surg Sports Traumatol Arthrosc. 2025 Jan;33(1):354-63
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/HE/101060693
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/3PE/PID2022-136787NB-I00
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2019-104156GB-I00
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/HE/101057693
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/952026
  • dc.rights © 2024 The Author(s). Knee Surgery, Sports Traumatology, Arthroscopy published by John Wiley & Sons Ltd on behalf of European Society of Sports Traumatology, Knee Surgery and Arthroscopy. This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/
  • dc.subject.keyword Antibiotic‐loaded bone cement
  • dc.subject.keyword Peri‐prosthetic joint infection
  • dc.subject.keyword Plain cement
  • dc.subject.keyword Total knee arthroplasty
  • dc.title Antibiotic-loaded bone cement is associated with a reduction of the risk of revision of total knee arthroplasty: Analysis of the Catalan Arthroplasty Register
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

Col·leccions

Articles (Hospital del Mar Research Institute)
Documents OpenAIRE (Open Access Infrastructure for Research in Europe)