Long Non-Coding RNAs As Potential Novel Prognostic Biomarkers in Colorectal Cancer

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  • dc.contributor.author Saus Martínez, Esterca
  • dc.contributor.author Brunet-Vega, Annaca
  • dc.contributor.author Iraola Guzmán, Susanaca
  • dc.contributor.author Pegueroles Queralt, Maria Cintaca
  • dc.contributor.author Gabaldón Estevan, Juan Antonio, 1973-ca
  • dc.contributor.author Pericay, Carlesca
  • dc.date.accessioned 2017-04-24T10:29:51Z
  • dc.date.available 2017-04-24T10:29:51Z
  • dc.date.issued 2016
  • dc.description.abstract Colorectal cancer (CRC) is the fourth most common cause of death worldwide. Surgery is usually the first line of treatment for patients with CRC but many tumors with similar histopathological features show significantly different clinical outcomes. The discovery of robust prognostic biomarkers in patients with CRC is imperative to achieve more effective treatment strategies and improve patient's care. Recent progress in next generation sequencing methods and transcriptome analysis has revealed that a much larger part of the genome is transcribed into RNA than previously assumed. Collectively referred to as non-coding RNAs (ncRNAs), some of these RNA molecules such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) have been shown to be altered and to play critical roles in tumor biology. This discovery leads to exciting possibilities for personalized cancer diagnosis, and therapy. Many lncRNAs are tissue and cancer-type specific and have already revealed to be useful as prognostic markers. In this review, we focus on recent findings concerning aberrant expression of lncRNAs in CRC tumors and emphasize their prognostic potential in CRC. Further studies focused on the mechanisms of action of lncRNAs will contribute to the development of novel biomarkers for diagnosis and disease progression.
  • dc.description.sponsorship TG group acknowledges support of the Spanish Ministry of Economy and Competitiveness grants, ‘Centro de Excelencia Severo Ochoa 2013-2017’ SEV-2012-0208, and BIO2012-37161 cofounded by European Regional Development Fund (ERDF); from the European Union and ERC Seventh Framework Programme (FP7/2007-2013) under grant agreement ERC-2012-StG-310325, and a grant from the European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No H2020-MSCA-ITN-2014-642095. CP group acknowledges support from the Fundació Parc Taulí by grants CIR2010040 and CIR2014023.
  • dc.format.mimetype application/pdfca
  • dc.identifier.citation Saus E, Brunet-Vega A, Iraola-Guzmán S, Pegueroles C, Gabaldón Esteban JA, Pericay C. Long Non-Coding RNAs As Potential Novel Prognostic Biomarkers in Colorectal Cancer. Frontiers in Genetics. 2016;7:54. DOI: 10.3389/fgene.2016.00054
  • dc.identifier.doi http://dx.doi.org/10.3389/fgene.2016.00054
  • dc.identifier.issn 1664-8021
  • dc.identifier.uri http://hdl.handle.net/10230/30884
  • dc.language.iso eng
  • dc.publisher Frontiersca
  • dc.relation.ispartof Frontiers in Genetics. 2016;7:54
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SEV2012-0208
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BIO2012-37161
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/310325
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/642095
  • dc.rights © 2016 Saus, Brunet-Vega, Iraola-Guzmán, Pegueroles, Gabaldón and Pericay. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri https://creativecommons.org/licenses/by/4.0/
  • dc.subject.keyword Long non-coding RNA
  • dc.subject.keyword ncRNA
  • dc.subject.keyword Prognostic marker
  • dc.subject.keyword Colorectal cancer
  • dc.subject.keyword Biomarker
  • dc.title Long Non-Coding RNAs As Potential Novel Prognostic Biomarkers in Colorectal Cancerca
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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