Maternal diet, prenatal exposure to dioxins and other persistent organic pollutants and anogenital distance in children

Papadopoulou, Eleni, 1985-; Vafeiadi, Marina, 1983-; Agramunt, Silvia; Mathianaki, Kleopatra; Karakosta, Polyxeni; Spanaki, Ariana; Besselink, Harrie; Kiviranta, Hannu; Rantakokko, Panu; Sarri, Katerina; Koutis, Antonis; Chatzi, Leda; Kogevinas, Manolis

Maternal diet, prenatal exposure to dioxins and other persistent organic pollutants and anogenital distance in children

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dc.contributor.author Papadopoulou, Eleni, 1985-
dc.contributor.author Vafeiadi, Marina, 1983-
dc.contributor.author Agramunt, Silvia
dc.contributor.author Mathianaki, Kleopatra
dc.contributor.author Karakosta, Polyxeni
dc.contributor.author Spanaki, Ariana
dc.contributor.author Besselink, Harrie
dc.contributor.author Kiviranta, Hannu
dc.contributor.author Rantakokko, Panu
dc.contributor.author Sarri, Katerina
dc.contributor.author Koutis, Antonis
dc.contributor.author Chatzi, Leda
dc.contributor.author Kogevinas, Manolis
dc.date.accessioned 2024-05-28T10:09:47Z
dc.date.available 2024-05-28T10:09:47Z
dc.date.issued 2013
dc.description.abstract We investigated the potential endocrine disruptive effect of prenatal exposure to persistent organic pollutants (POPs) through maternal diet, by measuring anogenital distance in newborns and young children. We included 231 mothers and their newborns measured at birth from the Rhea study in Crete, Greece and the Hmar study in Barcelona, Spain and 476 mothers and their children measured between 1 and 2 years from the Rhea study. We used food frequency questionnaires to assess maternal diet and estimated plasma dioxin-like activity by the Dioxin-Responsive Chemically Activated LUciferase eXpression (DR-CALUX®) and other POPs in maternal samples. We defined a “high-fat diet” score, as a prenatal exposure estimate, that incorporated intakes of red meat, processed meat, fatty fish, seafood, eggs and high-fat dairy products during pregnancy. Increasing maternal “high-fat diet” score was related to increasing dioxin-like activity and serum concentrations of lipophilic persistent organic pollutants in maternal blood. An inverse dose–response association was found between “high-fat diet” score and anoscrotal distance in newborn males. The highest tertile of the maternal score was associated with − 4.2 mm (95% CI − 6.6 to − 1.8) reduction in anoscrotal distance of newborn males, compared to the lowest tertile. A weak positive association was found between the “high-fat diet” score and anofourchetal distance in newborn females. In young children we found no association between maternal “high-fat diet” score and anogenital distances. In conclusion, maternal high-fat diet may be linked to high prenatal exposure to persistent organic pollutants and endocrine disruptive effects, resulting to phenotypic alterations of the reproductive system.
dc.description.sponsorship This study was partly supported by European projects (EU FP6-2003-Food-3-A NewGeneris, EU FP6. STREP Hiwate, EU FP7 ENV.2007.1.2.2.2. CHICOS, EU FP7 ENV.2008.1.2.1.6. Proposal No 226285 ENRIECO); and the Greek Ministry of Health (Program of Prevention of obesity and neurodevelopmental disorders in preschool children, in Heraklion district, Crete, Greece: 2011–2014).
dc.format.mimetype application/pdf
dc.identifier.citation Papadopoulou E, Vafeiadi M, Agramunt S, Mathianaki K, Karakosta P, Spanaki A, et al. Maternal diet, prenatal exposure to dioxins and other persistent organic pollutants and anogenital distance in children. Sci Total Environ. 2013 Sep;461-462:222-9. DOI: 10.1016/j.scitotenv.2013.05.005
dc.identifier.doi http://dx.doi.org/10.1016/j.scitotenv.2013.05.005
dc.identifier.issn 0048-9697
dc.identifier.uri http://hdl.handle.net/10230/60267
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof Science of the total environment. 2013 Sep;461-462:222-9
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/226285
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.keyword Pregnancy
dc.subject.keyword Maternal diet
dc.subject.keyword Persistent organic pollutants
dc.subject.keyword DR-CALUX
dc.subject.keyword Anogenital distance
dc.subject.keyword Rhea study
dc.title Maternal diet, prenatal exposure to dioxins and other persistent organic pollutants and anogenital distance in children
dc.type info:eu-repo/semantics/article
dc.type.version info:eu-repo/semantics/publishedVersion

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