A re-assessment of the value of markers of corticosteroid contact allergy in the Spanish baseline series: Clobetasol propionate in the spotlight

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• dc.contributor.author Mercader García, Pedro
• dc.contributor.author Giménez Arnau, Anna Maria
• dc.contributor.author Borrego, Leopoldo
• dc.date.accessioned 2025-04-17T06:08:58Z
• dc.date.available 2025-04-17T06:08:58Z
• dc.date.issued 2024
• dc.description.abstract Background: Budesonide and tixocortol pivalate as markers of contact allergy to corticosteroids have been questioned, as they are not able to detect a significant percentage of allergic patients. Objectives: To investigate the potential role of clobetasol propionate in enhancing corticosteroid sensitisation detection. Methods: Between January 2022 and December 2023, patients who attended centres involved in the Spanish Registry of Research in Contact Dermatitis and Cutaneous Allergy were tested with an extended baseline series that included budesonide, tixocortol pivalate, clobetasol propionate 0.1% in ethanol and 1% in petrolatum. Results: A total of 4338 patients were tested. Twenty-four patients were allergic to budesonide (0.55%, 95% CI: 0.37-0.82); nine patients were allergic to tixocortol pivalate (0.21%, 95% CI: 0.11-0.39); and 23 patients were allergic to clobetasol (0.53%, 95% CI: 0.35-0.79). Only four of those patients allergic to clobetasol were detected by budesonide and one by tixocortol pivalate. No significant differences in the number of positive tests were found between clobetasol in petrolatum or ethanol. Conclusions: In Spain budesonide remains the main corticosteroid allergy marker whereas the role of tixocortol pivalate is questionable. The addition of clobetasol propionate to the Spanish baseline series would improve the ability to detect patients allergic to corticosteroids.
• dc.format.mimetype application/pdf
• dc.identifier.citation Mercader-García P, Silvestre JF, Navarro-Triviño FJ, Giménez-Arnau AM, Pastor-Nieto MA, Cordoba-Guijarro S, et al. A re-assessment of the value of markers of corticosteroid contact allergy in the Spanish baseline series: Clobetasol propionate in the spotlight. Contact Dermatitis. 2024 Sep;91(3):228-36. DOI: 10.1111/cod.14639
• dc.identifier.doi http://dx.doi.org/10.1111/cod.14639
• dc.identifier.issn 0105-1873
• dc.identifier.uri http://hdl.handle.net/10230/70156
• dc.language.iso eng
• dc.publisher Wiley
• dc.relation.ispartof Contact Dermatitis. 2024 Sep;91(3):228-36
• dc.rights © 2024 The Author(s). Contact Dermatitis published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Budesonide
• dc.subject.keyword Clobetasol propionate
• dc.subject.keyword Contact dermatitis
• dc.subject.keyword Tixocortol pivalate
• dc.title A re-assessment of the value of markers of corticosteroid contact allergy in the Spanish baseline series: Clobetasol propionate in the spotlight
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion