SWI/SNF and RSC remodeler complexes bind to MBF-dependent genes
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- dc.contributor.author González Medina, Alberto, 1990-
- dc.contributor.author Pazo Pelegrí, Esther, 1993-
- dc.contributor.author Hidalgo Hernando, Elena
- dc.contributor.author Ayté del Olmo, José
- dc.date.accessioned 2022-01-20T07:06:45Z
- dc.date.issued 2021
- dc.description.abstract In fission yeast, MBF-dependent transcription is required for cells to complete S phase. The MBF transcription factor is regulated through a complex feedback mechanism that involves the co-repressors Yox1 and Nrm1 that are loaded onto MBF at the end of S phase, while positive transactivation is achieved through the constitutive binding of the co-activator Rep2. Here we show that Rep2 is required to fully recruit the chromatin remodelers SWI/SNF and RSC to MBF-regulated promoters. On the contrary, Nrm1 and Yox1, when bound to the MBF complex, block the approximation of these chromatin remodelers to MBF-regulated promoters. We propose that SWI/SNF and RSC are recruited to MBF-regulated genes, and RSC together with SAGA complex are important to regulate the G1-to-S transcriptional wave. Mutants of these remodeler complexes are highly sensitive when cells are exposed to insults that challenge DNA synthesis.
- dc.description.sponsorship This work was supported by grants from the Spanish Ministerio de Economia y Competitividad (MINECO) (Ministerio de Economía, Industria y Competitividad, Gobierno de España PGC2018-097248-B-I00), PLAN E and Feder and by Unidad de Excelencia María de Maeztu (CEX2018-000792-M). EH is recipient of an ICREA Academia Award (Instituci’ó Catalana de Recerca i Estudis Avançats, Generalitat de Catalunya).
- dc.format.mimetype application/pdf
- dc.identifier.citation González-Medina A, Pazo E, Hidalgo E, Ayté J. SWI/SNF and RSC remodeler complexes bind to MBF-dependent genes. Cell Cycle. 2021;20(24):2652-61. DOI: 10.1080/15384101.2021.2008203
- dc.identifier.doi http://dx.doi.org/10.1080/15384101.2021.2008203
- dc.identifier.issn 1538-4101
- dc.identifier.uri http://hdl.handle.net/10230/52267
- dc.language.iso eng
- dc.publisher Taylor & Francis
- dc.relation.ispartof Cell Cycle. 2021;20(24):2652-61
- dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PGC2018-097248-B-I00
- dc.rights © This is an Accepted Manuscript of an article published by Taylor & Francis in Cell cycle on 2021, available online: http://www.tandfonline.com/10.1080/15384101.2021.2008203.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.subject.keyword MBF
- dc.subject.keyword RSC complex
- dc.subject.keyword Start
- dc.title SWI/SNF and RSC remodeler complexes bind to MBF-dependent genes
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/acceptedVersion