The acute effects of ultraviolet radiation on the blood transcriptome are independent
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- dc.contributor.author Bustamante Pineda, Mariona
- dc.contributor.author Hernandez-Ferrer, Carles, 1987-
- dc.contributor.author Sarria-Trujillo, Yaris
- dc.contributor.author Harrison, Graham I.
- dc.contributor.author Nonell Mazelon, Lara, 1972-
- dc.contributor.author Kang, Wenjing
- dc.contributor.author Friedländer, Marc R.
- dc.contributor.author Estivill, Xavier, 1955-
- dc.contributor.author González, Juan Ramón
- dc.contributor.author Nieuwenhuijsen, Mark J.
- dc.contributor.author Young, Antony R.
- dc.date.accessioned 2023-11-21T06:39:55Z
- dc.date.available 2023-11-21T06:39:55Z
- dc.date.issued 2017
- dc.description.abstract The molecular basis of many health outcomes attributed to solar ultraviolet radiation (UVR) is unknown. We tested the hypothesis that they may originate from transcriptional changes in blood cells. This was determined by assessing the effect of fluorescent solar simulated radiation (FSSR) on the transcriptional profile of peripheral blood pre- and 6h, 24h and 48h post-exposure in nine healthy volunteers. Expression of 20 genes was down-regulated and one was up-regulated at 6h after FSSR. All recovered to baseline expression at 24h or 48h. These genes have been associated with immune regulation, cancer and blood pressure; health effects attributed to vitamin D via solar UVR exposure. Plasma 25-hydroxyvitamin D3 [25OHD3] levels increased over time after FSSR and were maximal at 48h. The increase was more pronounced in participants with low basal 25OHD3 levels. Mediation analyses suggested that changes in gene expression due to FSSR were independent of 25OHD3 and blood cell subpopulations.
- dc.description.sponsorship This study was supported by CERCA Programme / Generalitat de Catalunya and it was funded by the Instituto de Salud Carlos III FEDER (PI10/02235), the Spanish Ministry of Economy and Competitiveness (MTM2015-68140-R), the European Commission, under the Framework 7 Programme Environment Theme [Contract No. 227020: The Impact of Climate and Environmental Factors on Personal Ultraviolet Radiation Exposure and Human Health (ICEPURE)], and the UK National Institute for Health Research (NIHR) Biomedical Research Centre based at Guy's and St Thomas' NHS Foundation Trust and King's College London, UK. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the UK Department of Health. Wenjing Kang and Marc R. Friedländer acknowledge funding from the Strategic Research Area program of the Swedish Research Council through Stockholm University.
- dc.format.mimetype application/pdf
- dc.identifier.citation Bustamante M, Hernandez-Ferrer C, Sarria Y, Harrison GI, Nonell L, Kang W, Friedländer MR, Estivill X, González JR, Nieuwenhuijsen M, Young AR. The acute effects of ultraviolet radiation on the blood transcriptome are independent. Environ Res. 2017 Nov;159:239-48. DOI: 10.1016/j.envres.2017.07.045
- dc.identifier.doi http://dx.doi.org/10.1016/j.envres.2017.07.045
- dc.identifier.issn 0013-9351
- dc.identifier.uri http://hdl.handle.net/10230/58324
- dc.language.iso eng
- dc.publisher Elsevier
- dc.relation.ispartof Environ Res. 2017 Nov;159:239-48
- dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/227020
- dc.rights © Elsevier http://dx.doi.org/10.1016/j.envres.2017.07.045
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.subject.keyword Blood
- dc.subject.keyword Gene expression
- dc.subject.keyword MiRNA expression
- dc.subject.keyword Solar ultraviolet radiation
- dc.subject.keyword Vitamin D
- dc.title The acute effects of ultraviolet radiation on the blood transcriptome are independent
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/acceptedVersion