• The mechanism of action of pepR, a viral-derived peptide, against Staphylococcus aureus biofilms

  Pinto, Sandra N.; Dias, Susana A.; Cruz, Ana F.; Mil-Homens, Dalila; Fernandes, Fabio; Valle, Javier; Andreu Martínez, David; Prieto, Manuel; Castanho, Miguel A.R.B.; Coutinho, Ana; Salomé Veiga, Ana (Oxford University Press, 2019)

  Objectives: To investigate the mechanism of action at the molecular level of pepR, a multifunctional peptide derived from the Dengue virus capsid protein, against Staphylococcus aureus biofilms. Methods: Biofilm mass, ...
• The role of C-reactive protein levels on the association of physical activity with lung function in adults

  Fuertes, Elaine; Carsin, Anne-Elie; Garcia-Larsen, Vanessa; Guerra, Stefano; Pin, Isabelle; Leynaert, Bénédicte; Accordini, Simone; Martínez-Moratalla, Jesús; Antó i Boqué, Josep Maria; Urrutia, Isabel; Le Gouellec, Audrey; Heinrich, Joachim; Gislason, Thorarinn; Jõgi, Rain; Janson, Christer; Jarvis, Debbie; García Aymerich, Judith (Public Library of Science (PLoS), 2019)

  Objective: Regular physical activity may be associated with improved lung function via reduced systemic inflammation, although studies exploring this mechanism are rare. We evaluated the role of C-reactive protein in blood, ...
• Altered neocortical dynamics in a mouse model of Williams-Beuren syndrome

  Dasilva, Miguel; Navarro-Guzman, Alvaro; Ortiz Romero, Paula; Camassa, Alessandra; Muñoz-Cespedes, Alberto; Campuzano Uceda, María Victoria; Sanchez-Vives, Maria V. (Springer, 2019)

  Williams-Beuren syndrome (WBS) is a rare neurodevelopmental disorder characterized by moderate intellectual disability and learning difficulties alongside behavioral abnormalities such as hypersociability. Several structural ...
• Effects of prenatal exposure to particulate matter air pollution on corpus callosum and behavioral problems in children

  Mortamais, Marion; Pujol Martí, Jesús, 1981-; Martínez-Vilavella, Gerard; Fenoll, Raquel; Reynes, Christelle; Sabatier, Robert; Rivas, Ioar; Forns i Guzman, Joan, 1981-; Vilor Tejedor, Natàlia, 1988-; Alemany, Silvia; Cirach, Marta; Alvarez-Pedrerol, Mar; Nieuwenhuijsen, Mark J.; Sunyer Deu, Jordi (Elsevier, 2019)

  Objective: Air pollution (AP) may affect neurodevelopment, but studies about the effects of AP on the growing human brain are still scarce. We aimed to investigate the effects of prenatal exposure to AP on lateral ventricles ...
• Prenatal and postnatal exposure to air pollution and emotional and aggressive symptoms in children from 8 European birth cohorts

  Jorcano, Ainhoa; Lubczynska, Malgorzata Joanna; Pierotti, Livia; Sunyer Deu, Jordi; Guxens Junyent, Mònica (Elsevier, 2019)

  Background: The association between air pollution exposure and emotional and behavioural problems in children is unclear. We aimed to assess prenatal and postnatal exposure to several air pollutants and child's depressive ...
• Sex-specific incidence of asthma, rhinitis and respiratory multimorbidity before and after puberty onset: individual participant meta-analysis of five birth cohorts collaborating in MeDALL

  Hohmann, Cynthia; Keller, Theresa; Gehring, Ulrike; Wijga, Alet; Standl, Marie; Kull, Inger; Bergström, Anna; Lehmann, Irina; von Berg, Andrea; Heinrich, Joachim; Lau, Susanne; Wahn, Ulrich; Maier, Dieter; Antó i Boqué, Josep Maria; Bousquet, Jean; Smit, Henriëtte A.; Keil, Thomas; Roll, Stephanie (BMJ Publishing Group, 2019)

  Introduction To understand the puberty-related sex shift in the prevalence of asthma and rhinitis as single entities and as respiratory multimorbidities, we investigated if there is also a sex-specific and puberty-related ...
• Putting words in context: LSTM language models and lexical ambiguity

  Boleda, Gemma; Gulordava, Kristina; Aina, Laura (ACL (Association for Computational Linguistics), 2019)

  In neural network models of language, words are commonly represented using context invariant representations (word embeddings) which are then put in context in the hidden layers. Since words are often ambiguous, representing ...
• ATP, Mg2+, nuclear phase separation, and genome accessibility

  Wright, Roni H.G.; Le Dily, François; Beato, Miguel (Elsevier, 2019)

  Misregulation of the processes controlling eukaryotic gene expression can result in disease. Gene expression is influenced by the surrounding chromatin; hence the nuclear environment is also of vital importance. Recently, ...
• eDiVA-Classification and prioritization of pathogenic variants for clinical diagnostics

  Bosio, Mattia; Drechsel, Oliver; Rahman, Rubayte; Muyas, Francesc; Rabionet, Raquel; Bezdan, Daniela; Domenech Salgado, Laura; Hor, Hyun; Schott, Jean-Jacques; Munell, Francina; Colobran, Roger; Macaya, Alfons; Estivill, Xavier, 1955-; Ossowski, Stephan (Wiley, 2019)

  Mendelian diseases have shown to be an and efficient model for connecting genotypes to phenotypes and for elucidating the function of genes. Whole-exome sequencing (WES) accelerated the study of rare Mendelian diseases in ...
• RNA structure drives interaction with proteins

  Sanchez de Groot, Natalia; Armaos, Alexandros; Graña-Montes, Ricardo; Alriquet, Marion; Calloni, Giulia; Vabulas, R. Martin; Tartaglia, Gian Gaetano (Nature Research, 2019)

  The combination of high-throughput sequencing and in vivo crosslinking approaches leads to the progressive uncovering of the complex interdependence between cellular transcriptome and proteome. Yet, the molecular determinants ...
• Salbutamol modifies the neuromuscular junction in a mouse model of ColQ myasthenic syndrome

  McMacken, Grace M.; Spendiff, Sally; Whittaker, Roger G.; O'Connor, Emily; Howarth, Rachel M.; Boczonadi, Veronika; Horvath, Rita; Slater, Clarke R.; Lochmüller, Hanns (Oxford University Press, 2019)

  The β-adrenergic agonists salbutamol and ephedrine have proven to be effective as therapies for human disorders of the neuromuscular junction, in particular many subsets of congenital myasthenic syndromes. However, the ...
• Idioms and the syntax/semantics interface of descriptive content vs. reference

  McNally, Louise, 1965-; Gehrke, Berit (De Gruyter, 2019)

  The syntactic literature on idioms contains some proposals that are surprising from a compositional perspective. For example, Sportiche (2005) and Cecchetto and Donati (2015) propose that, in the case of verb-object idioms, ...
• Whole-genome DNA hyper-methylation in iPSC-derived dopaminergic neurons from Parkinson's disease patients

  Fernández-Santiago, Ruben; Merkel, Angelika; Castellano, Giancarlo; Heath, Simon; Raya Chamorro, Ángel; Tolosa, Eduard; Martí, Maria José; Consiglio, Antonella; Ezquerra, Mario (BioMed Central, 2019)

  Background: Parkinson’s disease (PD) is characterized by the loss of midbrain dopaminergic neurons (DAn). Previously, we described the presence of DNA hyper- and hypo-methylation alterations in induced pluripotent stem ...
• Three-dimensional genomic structure and cohesin occupancy correlate with transcriptional activity during spermatogenesis

  Vara, Covadonga; Paytuví Gallart, Andreu; Cuartero, Yasmina; Le Dily, François; Garcia, Francisca; Salvà-Castro, Judit; Gómez-H, Laura; Julià, Eva; Moutinho, Catia; Aiese Cigliano, Riccardo; Sanseverino, Walter; Fornas Carreño, Oscar; Pendás, Alberto M.; Heyn, Holger; Waters, Paul D.; Marti-Renom, Marc A.; Ruiz Herrera, Aurora (Elsevier, 2019)

  Mammalian gametogenesis involves dramatic and tightly regulated chromatin remodeling, whose regulatory pathways remain largely unexplored. Here, we generate a comprehensive high-resolution structural and functional atlas ...
• Investigando bandas juveniles en tres continentes

  Feixa, Carles, 1962- (Asociación Mensa España (https://www.mensa.es/), 2019)

  Este texto presenta los fundamentos conceptuales del proyecto TRANSGANG (Transnational Gangs as Agents of Mediation: Experiences of Conflict Resolution in Street Youth Organizations in Southern Europe, North Africa and the ...
• The role of clonal communication and heterogeneity in breast cancer

  Martín-Pardillos, Ana; Miravet Verde, Samuel; Serrano Pubull, Luis, 1982-; Lluch-Senar, Maria 1982-; Ramón y Cajal, Santiago (BioMed Central, 2019)

  Background: Cancer is a rapidly evolving, multifactorial disease that accumulates numerous genetic and epigenetic alterations. This results in molecular and phenotypic heterogeneity within the tumor, the complexity of which ...
• PyToBI: a toolkit for ToBI labeling under Python

  Domínguez Bajo, Mónica; Rohrer, Patrick Louis; Soler-Company, Juan (International Speech Communication Association (ISCA), 2019)

  PyToBI is introduced as a user-friendly toolkit for the automatic annotation of intonation contours using the Tones and Breaks Indexes convention, known as ToBI. Index Terms: speech prosody, ToBI, automatic annotation, speech ...
• Communicating genome architecture: biovisualization of the genome, from data analysis and hypothesis generation to communication and learning

  Goodstadt, Mike N.; Martí Renom, Marc A. (Elsevier, 2019)

  Genome discoveries at the core of biology are made by visual description and exploration of the cell, from microscopic sketches and biochemical mapping to computational analysis and spatial modeling. We outline the ...
• Specific contributions of cohesin-SA1 and cohesin-SA2 to TADs and polycomb domains in embryonic stem cells

  Cuadrado, Ana; Giménez-Llorente, Daniel; Kojic, Aleksandar; Rodríguez-Corsino, Miriam; Cuartero, Yasmina; Martín-Serrano, Guillermo; Gómez López, Gonzalo; Marti-Renom, Marc A.; Losada, Ana (Elsevier, 2019)

  Cohesin exists in two variants carrying either STAG/SA1 or SA2. Here we have addressed their specific contributions to the unique spatial organization of the mouse embryonic stem cell genome, which ensures super-enhancer-dependent ...
• A Model for evaluating popularity and semantic information variations in radio listening sessions

  Porcaro, Lorenzo; Gómez Gutiérrez, Emilia, 1975- (2019)

  Listening to music radios is an activity that since the 20th century is part of the cultural habits for people all over the world. While in the case of analog radios DJs are in charge of selecting the music to be ...

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