• Changes in the free-energy landscape of p38α MAP kinase through its canonical activation and binding events as studied by enhanced molecular dynamics simulations

  Kuzmanic, Antonija; Sutto, Ludovico; Saladino, Giorgio; Nebreda, Ángel R.; Gervasio, Francesco L.; Orozco, Modesto (eLife, 2017)

  p38α is a Ser/Thr protein kinase involved in a variety of cellular processes and pathological conditions, which makes it a promising pharmacological target. Although the activity of the enzyme is highly regulated, its ...
• Sphingomyelin metabolism controls the shape and function of the Golgi cisternae

  Campelo, Felix; van Galen, Josse; Turacchio, Gabriele; Parashuraman, Seetharaman; Kozlov, Michael M.; García Parajó, María F.; Malhotra, Vivek (eLife, 2017)

  The flat Golgi cisterna is a highly conserved feature of eukaryotic cells, but how is this morphology achieved and is it related to its function in cargo sorting and export? A physical model of cisterna morphology led us ...
• Alternative transcriptional regulation in genome-reduced bacteria

  Miravet Verde, Samuel; Lloréns Rico, Verónica, 1989-; Serrano Pubull, Luis, 1982- (Elsevier, 2017)

  Transcription is a core process of bacterial physiology, and as such it must be tightly controlled, so that bacterial cells maintain steady levels of each RNA molecule in homeostasis and modify them in response to ...
• Constitutively active SMAD2/3 are broad-scope potentiators of transcription-factor-mediated cellular reprogramming

  Ruetz, Tyson Joel; Pfisterer, Ulrich; Di Stefano, Bruno, 1984-; Ashmore, James; Beniazza, Meryam; Tian, Tian V.; Kaemena, Daniel F.; Tosti, Luca; Tan, Wenfang; Manning, Jonathan R.; Chantzoura, Eleni; Ottosson, Daniella Rylander; Collombet, Samuel; Johnsson, Anna E.; Cohen, Erez; Yusa, Kosuke; Linnarsson, Sten; Graf, T. (Thomas); Parmar, Malin; Kaji, Keisuke (Elsevier, 2017)

  Reprogramming of cellular identity using exogenous expression of transcription factors (TFs) is a powerful and exciting tool for tissue engineering, disease modeling, and regenerative medicine. However, generation of desired ...
• Spatiotemporal proteomic profiling of Huntington's disease inclusions reveals widespread loss of protein function

  Hosp, Fabian; Gutiérrez Ángel, Sara; Schaefer, Martin H.; Cox, Jürgen; Meissner, Felix; Hipp, Mark Steffen; Hartl, F. Ulrich; Klein, Rüdiger; Dudanova, Irina; Mann, Matthias (Elsevier, 2017)

  Aggregation of polyglutamine-expanded huntingtin exon 1 (HttEx1) in Huntington's disease (HD) proceeds from soluble oligomers to late-stage inclusions. The nature of the aggregates and how they lead to neuronal dysfunction ...
• Wolf-Hirschhorn syndrome candidate 1 is necessary for correct hematopoietic and B cell development

  Campos Sańchez, Elena; Deleyto Seldas, Nerea; Domínguez, Verónica; Carrillo, Enrique; Ura, Kiyoe; Rocha, Pedro P.; Kim, Jung Hyun; Aljoufi, Arafat; Esteve-Codina, Anna; Dabad, Marc; Gut, Marta; Heyn, Holger; Kaneda, Yasufumi; Nimura, Keisuke; Skok, Jane Amanda; Martínez Frías, María Luísa; Cobaleda, César (Elsevier, 2017)

  Immunodeficiency is one of the most important causes of mortality associated with Wolf-Hirschhorn syndrome (WHS), a severe rare disease originated by a deletion in chromosome 4p. The WHS candidate 1 (WHSC1) gene has been ...
• Major roles for pyrimidine dimers, nucleotide excision repair, and ATR in the alternative splicing response to UV irradiation

  Muñoz, Manuel Javier; Nieto Moreno, Nicolás; Giono, Luciana E.; Cambindo Botto, Adrián E.; Dujardin, Gwendal; Bastianello, Giulia; Lavore, Stefania; Torres Méndez, Antonio; Menck, Carlos Frederico Martins; Blencowe, Benjamin J.; Irimia, Manuel; Foiani, Marco; Kornblihtt, Alberto R. (Elsevier, 2017)

  We have previously found that UV irradiation promotes RNA polymerase II (RNAPII) hyperphosphorylation and subsequent changes in alternative splicing (AS). We show now that UV-induced DNA damage is not only necessary but ...
• Modeling dynamics and function of bone marrow cells in mouse liver regeneration

  Pedone, Elisa, 1985-; Olteanu, Vlad Aris; Marucci, Lucia; Muñoz-Martin, Maria Isabel; Youssef, Sameh A.; de Bruin, Alain; Cosma, Maria Pia, 1970- (Elsevier, 2017)

  In rodents and humans, the liver can efficiently restore its mass after hepatectomy. This is largely attributed to the proliferation and cell cycle re-entry of hepatocytes. On the other hand, bone marrow cells (BMCs) migrate ...
• Editorial: role of stem cells in skeletal muscle development, regeneration, repair, aging, and disease

  Muñoz Cánoves, Pura, 1962-; Carvajal, Jaime J.; López de Munain, Adolfo; Izeta, Ander (Frontiers, 2016)
• Patient independent representation of the detailed cardiac ventricular anatomy

  Paun, Bruno; Bijnens, Bart; Iles, Tinen; Iaizzo, Paul A.; Butakoff, Constantine (Elsevier, 2017)

  Reparameterization of surfaces is a widely used tool in computer graphics known mostly from the remeshing algorithms. Recently, the surface reparameterization techniques started to gain popularity in the field of medical ...
• LAN property for an ergodic diffusion with jumps

  Kohatsu, Arturo; Nualart, Eulàlia; Tran, Ngoc Khue (Taylor & Francis (Routledge), 2017)

  In this paper, we consider a multidimensional ergodic diffusion with jumps driven by a Brownian motion and a Poisson random measure associated with a compound Poisson process, whose drift coefficient depends on an unknown ...
• Systemic human ILC precursors provide a substrate for tissue ILC differentiation

  Lim, Ai Ing; Stadhouders, Ralph; Graf, T. (Thomas); Di Santo, James P. (Elsevier, 2017)

  Innate lymphoid cells (ILCs) represent innate versions of T helper and cytotoxic T cells that differentiate from committed ILC precursors (ILCPs). How ILCPs give rise to mature tissue-resident ILCs remains unclear. Here, ...
• Novel efficient genome-wide SNP panels for the conservation of the highly endangered Iberian lynx

  Kleinman Ruiz, Daniel; Martínez Cruz, Begoña; Soriano, Laura; Lucena Pérez, María; Cruz, Fernando; Villanueva, Beatriz; Fernández, Jesús María; Godoy, José A. (BioMed Central, 2017)

  BACKGROUND: The Iberian lynx (Lynx pardinus) has been acknowledged as the most endangered felid species in the world. An intense contraction and fragmentation during the twentieth century left less than 100 individuals ...
• DNA methylation and exposure to ambient air pollution in two prospective cohorts

  Plusquin, Michelle; Sayols, Sergi; Chadeau-Hyam, Marc (Elsevier, 2017)

  Long-term exposure to air pollution has been associated with several adverse health effects including cardiovascular, respiratory diseases and cancers. However, underlying molecular alterations remain to be further ...
• De novo mutations in SLC25A24 cause a craniosynostosis syndrome with hypertrichosis, progeroid appearance, and mitochondrial dysfunction

  Ehmke, Nadja; Hecht, Jochen; Kornak, Uwe (Elsevier, 2017)

  Gorlin-Chaudhry-Moss syndrome (GCMS) is a dysmorphic syndrome characterized by coronal craniosynostosis and severe midface hypoplasia, body and facial hypertrichosis, microphthalmia, short stature, and short distal phalanges. ...
• Compaction of duplex nucleic acids upon native electrospray mass spectrometry

  Porrini, Massimiliano; Rosu, Frédéric; Rabin, Clémence; Darré, Leonardo; Gómez, Hansel; Orozco, Modesto; Gabelica, Valérie (American Chemical Society (ACS), 2017)

  We report on the fate of nucleic acids conformation in the gas phase as sampled using native mass spectrometry coupled to ion mobility spectrometry. On the basis of several successful reports for proteins and their complexes, ...
• Bottom up ethics - neuroenhancement in education and employment

  Bard, Imre; Revuelta, Gemma; Saladié, Núria; Zwart, Hub (Springer, 2018)

  Neuroenhancement involves the use of neurotechnologies to improve cognitive, affective or behavioural functioning, where these are not judged to be clinically impaired. Questions about enhancement have become one of the ...
• Sound object classification for symbolic audio mosaicing: a proof-of-concept

  Janer Mestres, Jordi; Haro Berois, Martín; Roma Trepat, Gerard; Fujishima, Takuya; Kojima, Naoaki ([Sound and Music Computing], 2009)

  Sample-based music composition often involves the task of manually searching appropriate samples from existing audio. Audio mosaicing can be regarded as a way to automatize this process by specifying the desired audio ...
• Job loss, unemployment and the incidence of hazardous drinking during the late 2000s recession in Europe among adults aged 50-64 years

  Bosque Prous, Marina, 1984-; Espelt Hernández, Albert, 1981-; Sordo, Luis; Guitart, Anna (Guitart i Garcia); Brugal i Puig, M. Teresa; Bravo, María José (Public Library of Science (PLoS), 2015)

  BACKGROUND: To estimate the incidence of hazardous drinking in middle-aged people during an economic recession and ascertain whether individual job loss and contextual changes in unemployment influence the incidence rate ...
• Neurodegeneration and cancer: where the disorder prevails

  Klus, Petr, 1985-; Cirillo, Davide; Botta Orfila, Teresa; Tartaglia, Gian Gaetano (Nature Publishing Group, 2015)

  It has been reported that genes up-regulated in cancer are often down-regulated in neurodegenerative disorders and vice versa. The fact that apparently unrelated diseases share functional pathways suggests a link between ...

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