• Increasing phenotypic annotation improves the diagnostic rate of exome sequencing in a rare neuromuscular disorder

  Thompson, Rachel; Papakonstantinou Ntalis, Anastasios; Beltran, Sergi; Topf, Ana; de Paula Estephan, Eduardo; Poloavarapu, Kiran; Hoen, Peter A. C.; Missier, Paolo; Lochmüller, Hanns (Wiley-VCH Verlag, 2019)

  Phenotype-based filtering and prioritization contribute to the interpretation of genetic variants detected in exome sequencing. However, it is currently unclear how extensive this phenotypic annotation should be. In this ...
• Gene gain and loss across the Metazoan Tree of Life

  Fernández, Rosa; Gabaldón Estevan, Juan Antonio, 1973- (Nature Research, 2020)

  Although recent research has revealed high genomic complexity in the earliest-splitting animals and their ancestors, the macroevolutionary trends orchestrating gene repertoire evolution throughout the animal phyla remain ...
• European cyclists' travel behavior: differences and similarities between seven European (PASTA) cities

  Raser, Elisabeth; Gaupp-Berghausen, Mailin; Dons, Evi; Anaya Boig, Esther; Avila-Palencia, Ione, 1985-; Brand, Christian; Castro, Alberto; Clark, Anna; Eriksson, Ulf; Götschi, Thomas; Int Panis, Luc; Kahlmeier, Sonja; Laeremans, Michelle; Mueller, Natalie, 1988-; Nieuwenhuijsen, Mark J.; Orjuela, Juan Pablo; Rojas Rueda, David, 1979-; Standaert, Arnout; Stigell, Erik; Gerike, Regine (Elsevier, 2018)

  While the annual number of trips of the average urban inhabitant has grown steadily in recent years, people are becoming less active while doing so. This lack of physical activity causes major health problems for individuals ...
• Impact of the social and natural environment on preschool-age children weight

  Petraviciene, Inga; Grazuleviciene, Regina; Andrušaitytė, Sandra; Dedele, Audrius; Nieuwenhuijsen, Mark J. (MDPI, 2018)

  Background: The complex impact of environmental and social factors on preschool children being overweight/obese is unclear. We examined the associations between the levels of green space exposure and the risk of being ...
• Impact of short-term traffic-related air pollution on the metabolome - Results from two metabolome-wide experimental studies

  van Veldhoven, Karin; Kiss, Agneta; Keski-Rahkonen, Pekka; Robinot, Nivonirina; Scalbert, Augustin; Cullinan, Paul; Chung, Kian Fan; Collins, Peter; Sinharay, Rudy; Barratt, Benjamin M.; Nieuwenhuijsen, Mark J.; Ambros, Albert; Carrasco Turigas, Glòria; Vlaanderen, Jelle; Vermeulen, Roel; Portengen, Lützen; Kyrtopoulos, Sosterios A.; Ponzi, Erica; Chadeau-Hyam, Marc; Vineis, Paolo (Elsevier, 2019)

  Exposure to traffic-related air pollution (TRAP) has been associated with adverse health outcomes but underlying biological mechanisms remain poorly understood. Two randomized crossover trials were used here, the Oxford ...
• Airway responsiveness to methacholine and incidence of COPD: an international prospective cohort study

  Marcon, Alessandro; Fuertes, Elaine; García Aymerich, Judith; Ageing Lungs In European Cohorts study (BMJ Publishing Group, 2018)

  Background: It has been debated, but not yet established, whether increased airway responsiveness can predict COPD. Recognising this link may help in identifying subjects at risk. Objective: We studied prospectively whether ...
• Availability, use of, and satisfaction with green space, and children's mental wellbeing at age 4 years in a multicultural, deprived, urban area: results from the Born in Bradford cohort study

  McEachan, Rosemary R.C.; Yang, Tiffany C.; Roberts, Hannah; Pickett, Kate E.; Arseneau-Powell, Diana; Gidlow, Christopher J.; Wright, John; Nieuwenhuijsen, Mark J. (Elsevier, 2018)

  Background: It is unknown whether the quantity or quality of green space is more important for mental wellbeing. We aimed to explore associations between availability of, satisfaction with, and use of green space and mental ...
• The effects of population tuning and trial-by-trial variability on information encoding and behavior

  Nogueira, Ramon; Peltier, Nicole E.; Anzai, Akiyuki; DeAngelis, Gregory C.; Martínez-Trujillo, Julio; Moreno-Bote, Rubén (Society for Neuroscience, 2020)

  Identifying the features of population responses that are relevant to the amount of information encoded by neuronal populations is a crucial step toward understanding population coding. Statistical features, such as tuning ...
• Robust algorithms with polynomial loss for near-unanimity CSPs

  Dalmau, Víctor; Kozik, Marcin; Krokhin, Andrei; Makarychev, Konstantin; Makarychev, Yury; Opršal, Jakub (SIAM (Society for Industrial and Applied Mathematics), 2019)

  An instance of the constraint satisfaction problem (CSP) is given by a family of constraints on overlapping sets of variables, and the goal is to assign values from a fixed domain to the variables so that all constraints ...
• Primate amygdala neurons simulate decision drocesses of social partners

  Grabenhorst, Fabian; Báez-Mendoza, Raymundo; Genest, Wilfried; Deco, Gustavo; Schultz, Wolfram (Elsevier, 2019)

  By observing their social partners, primates learn about reward values of objects. Here, we show that monkeys’ amygdala neurons derive object values from observation and use these values to simulate a partner monkey’s ...
• Low entropy map of brain oscillatory activity identifies spatially localized events

  Vila-Vidal, Manel; Pérez-Enríquez, Carmen; Principe, Alessandro; Rocamora, Rodrigo; Deco, Gustavo; Tauste Campo, Adrià (Elsevier, 2020)

  The spatial mapping of localized events in brain activity critically depends on the correct identification of the pattern signatures associated with those events. For instance, in the context of epilepsy research, a number ...
• Human confidence judgments reflect reliability-based hierarchical integration of contextual information

  Schustek, Philipp; Hyafil, Alexandre; Moreno-Bote, Rubén (Nature Research, 2019)

  Our immediate observations must be supplemented with contextual information to resolve ambiguities. However, the context is often ambiguous too, and thus it should be inferred itself to guide behavior. Here, we introduce ...
• Disrupted brain structural connectivity in pediatric bipolar disorder with psychosis

  Fernandes, Henrique M.; Cabral, Joana; van Hartevelt, Tim J.; Lord, Louis-David; Gleesborg, Carsten; Møller, Arne; Deco, Gustavo; Whybro, Peter C.; Petrovic, Predrag; James, Anthony C.; Kringelbach, Morten L. (Nature Research, 2019)

  Bipolar disorder (BD) has been linked to disrupted structural and functional connectivity between prefrontal networks and limbic brain regions. Studies of patients with pediatric bipolar disorder (PBD) can help elucidate ...
• Discovery of key whole-brain transitions and dynamics during human wakefulness and non-REM sleep

  Stevner, Angus B.A.; Vidaurre, Diego; Cabral, Joana; Rapuano, Kristina M.; Nielsen, Søren Føns Vind; Tagliazucchi, Enzo; Laufs, Helmut; Vuust, Peter; Deco, Gustavo; Woolrich, Mark W.; van Someren, Eus; Kringelbach, Morten L. (Nature Research, 2019)

  The modern understanding of sleep is based on the classification of sleep into stages defined by their electroencephalography (EEG) signatures, but the underlying brain dynamics remain unclear. Here we aimed to move ...
• Characterizing the dynamical complexity underlying meditation

  Escrichs, Anira; Sanjuán, Ana; Atasoy, Selen; López-González, Ane; Garrido, César; Càmara, Estela; Deco, Gustavo (Frontiers, 2019)

  Over the past 2,500 years, contemplative traditions have explored the nature of the mind using meditation. More recently, neuroimaging research on meditation has revealed differences in brain function and structure in ...
• Model cortical responses for the detection of perceptual onsets and beat tracking in singing

  Coath, Martin; Denham, Susan L.; Smith, Leigh M.; Honing, Henkjan; Hazan, Amaury; Holonowicz, Piotr; Purwins, Hendrick (Taylor & Francis, 2009)

  We describe a biophysically motivated model of auditory salience based on a model of cortical responses and present results that show that the derived measure of salience can be used to identify the position of perceptual ...
• On the interrelation between listener characteristics and the perception of emotion in classical orchestra music

  Schedl, Markus; Gómez Gutiérrez, Emilia, 1975-; Trent, Erika S.; Tkalčič, Marko; Eghbal-Zadeh, Hamid; Martorell Domínguez, Agustín (Institute of Electrical and Electronics Engineers (IEEE), 2017)

  This study deals with the strong relationship between emotions and music, investigating three main research questions: (RQ1) Are there differences in human music perception (e.g., emotions, tempo, instrumentation, and ...
• Trends and perspectives in music cognition research and technology

  Purwins, Hendrick; Hardoon, David R. (Taylor & Francis, 2009)
• Characteristic sounds facilitate object search in real-life scenes

  Kvasova, Daria; Garcia-Vernet, Laia; Soto Faraco, Salvador (Frontiers, 2019)

  Real-world events do not only provide temporally and spatially correlated information across the senses, but also semantic correspondences about object identity. Prior research has shown that object sounds can enhance ...
• Awakening: Predicting external stimulation to force transitions between different brain states

  Deco, Gustavo; Cruzat, Josephine; Cabral, Joana; Tagliazucchi, Enzo; Laufs, Helmut; Logothetis, Nikos K.; Kringelbach, Morten L. (National Academy of Sciences, 2019)

  A fundamental problem in systems neuroscience is how to force a transition from one brain state to another by external driven stimulation in, for example, wakefulness, sleep, coma, or neuropsychiatric diseases. This requires ...

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