• Centiloid cut-off values for optimal agreement between PET and CSF core AD biomarkers

  Salvadó, Gemma; Molinuevo, José Luis; Brugulat Serrat, Anna, 1986-; Falcón, Carles; Grau-Rivera, Oriol; Suárez-Calvet, Marc; Pavía Segura, Javier; Niñerola-Baizán, Aida; Perissinotti, Andrés; Lomeña, Francisco; Minguillón, Carolina; Fauria, Karine; Zetterberg, Henrik; Blennow, Kaj; Gispert López, Juan Domingo; Alzheimer’s Disease Neuroimaging Initiative (BioMed Central, 2019)

  Background: The Centiloid scale has been developed to standardize measurements of amyloid PET imaging. Reference cut-off values of this continuous measurement enable the consistent operationalization of decision-making for ...
• Las dimensiones sociales de la percepción de la energía nuclear: un análisis del caso español (1960-2015)

  Espluga Trenc, Josep; Medina, Beatriz; Presas, Albert; Rubio Varas, Mar; De la Torre, Joseba (CSIC, 2017)

  Nuclear energy is a complex technology that requires intensive use of resources and high centralized decision-making processes, whose governance poses a real challenge for democratic societies. In this article we explore ...
• Benchmarking single-cell RNA sequencing protocols for cell atlas projects

  Mereu, Elisabetta; Lafzi, Atefeh; Moutinho, Catia; Gut, Marta; Gut, Ivo Glynne; Heyn, Holger (Nature Research, 2020)

  Single-cell RNA sequencing (scRNA-seq) is the leading technique for characterizing the transcriptomes of individual cells in a sample. The latest protocols are scalable to thousands of cells and are being used to compile ...
• Fungal evolution: cellular, genomic and metabolic complexity

  Naranjo Ortiz, Miguel Ángel, 1989-; Gabaldón Estevan, Juan Antonio, 1973- (Wiley, 2020)

  The question of how phenotypic and genomic complexity are inter-related and how they are shaped through evolution is a central question in biology that historically has been approached from the perspective of animals and ...
• HaploTypo: a variant-calling pipeline for phased genomes

  Pegueroles Queralt, Maria Cinta; Mixão, Verónica; Carreté Muñoz, Laia, 1990-; Molina, Manuel; Gabaldón Estevan, Juan Antonio, 1973- (Oxford University Press, 2020)

  SUMMARY: An increasing number of phased (i.e. with resolved haplotypes) reference genomes are available. However, the most genetic variant calling tools do not explicitly account for haplotype structure. Here, we present ...
• MetaPhOrs 2.0: integrative, phylogeny-based inference of orthology and paralogy across the tree of life

  Chorostecki, Uciel; Molina, Manuel; Pryszcz, Leszek Piotr, 1985-; Gabaldón Estevan, Juan Antonio, 1973- (Oxford University Press, 2020)

  Inferring homology relationships across genes in different species is a central task in comparative genomics. Therefore, a large number of resources and methods have been developed over the years. Some public databases ...
• Hierarchical chromatin organization detected by TADpole

  Soler-Vila, Paula; Cuscó Pons, Pol, 1987-; Farabella, Irene; Di Stefano, Marco; Martí Renom, Marc A. (Oxford University Press, 2020)

  The rapid development of Chromosome Conformation Capture (3C-based techniques), as well as imaging together with bioinformatics analyses, has been fundamental for unveiling that chromosomes are organized into the so-called ...
• A reconstituted mammalian APC-kinesin complex selectively transports defined packages of axonal mRNAs

  Baumann, Sebastian; Komissarov, Artem; Gili, Maria; Ruprecht, Verena; Wieser, Stefan; Maurer, Sebastian (American Association for the Advancement of Science (AAAS), 2020)

  Through the asymmetric distribution of messenger RNAs (mRNAs), cells spatially regulate gene expression to create cytoplasmic domains with specialized functions. In neurons, mRNA localization is required for essential ...
• The noun-verb distinction in Catalan Sign Language: an exo-skeletal approach

  Quer, Josep, 1965-; Ribera-Llonc, Eulàlia; Espinal i Farré, M. Teresa (John Benjamins Publishing, 2019)

  This paper investigates the morpho-phonological differences between the members of related noun-verb pairs in Catalan Sign Language. Like parallel investigations in other sign languages, our experimental work provides ...
• Functional and molecular heterogeneity of D2R neurons along dorsal ventral axis in the striatum

  Puighermanal Puigvert, Emma, 1983-; Castell, Laia; Esteve-Codina, Anna; Melser, Su; Kaganovsky, Konstantin; Zussy, Charleine; Boubaker-Vitre, Jihane; Gut, Marta; Rialle, Stephanie; Kellendonk, Christoph; Sanz, Elisenda; Quintana, Albert; Marsicano, Giovanni; Martin, Miquel; Rubinstein, Marcelo; Girault, Jean-Antoine; Ding, Jun B.; Valjent, Emmanuel (Nature Research, 2020)

  Action control is a key brain function determining the survival of animals in their environment. In mammals, neurons expressing dopamine D2 receptors (D2R) in the dorsal striatum (DS) and the nucleus accumbens (Acb) jointly ...
• The conspicuous absence of class and privilege in the study of resistance in peacebuilding contexts

  Íñiguez de Heredia, Marta (Taylor & Francis, 2018)

  Attention to everyday forms of resistance in the liberal peace debates has provided a more sophisticated critique of peacebuilding but the concept of resistance remains limited. The paper argues that this is because leading ...
• The notion of focus and its relation to contrast in Catalan Sign Language (LSC)

  Navarrete González, Alexandra (Centro de Investigação em Educação (INED), 2019)

  In this paper, we describe the different syntactic and prosodic manual and non-manual markers used in the expression of focus and contrast in LSC. Given that in LSC contrast markers may also be found in topics, we follow ...
• Reduplication revisited: verbal plurality and exhaustivity in the visual-gestural modality

  Quer, Josep, 1965- (Centro de Investigação em Educação (INED), 2019)

  From the very early stages of sign language research (Klima & Bellugi, 1979 for ASL) and in subsequent descriptions of unrelated sign languages, a reduplicative morpheme in verbal morphology has been identified as encoding ...
• Phylogenomics identifies an ancestral burst of gene duplications predating the diversification of aphidomorpha

  Julca, Irene; Marcet Houben, Marina; Cruz, Fernando; Vargas-Chavez, Carlos; Johnston, John Spencer; Gómez Garrido, Jèssica; Frias, Leonor; Corvelo, André; Loska, Damian; Cámara, Francisco; Gut, Marta; Alioto, Tyler; Latorre, Amparo; Gabaldón Estevan, Juan Antonio, 1973- (Oxford University Press, 2020)

  Aphids (Aphidoidea) are a diverse group of hemipteran insects that feed on plant phloem sap. A common finding in studies of aphid genomes is the presence of a large number of duplicated genes. However, when these duplications ...
• Association of fish consumption and mercury exposure during pregnancy with metabolic health and inflammatory biomarkers in children

  Stratakis, Nikos; Borràs, Eva; Sabidó Aguadé, Eduard, 1981-; Basagaña Flores, Xavier; Bustamante Pineda, Mariona; Casas Sanahuja, Maribel; Fossati, Serena; González Ruiz, Juan Ramón; Maitre, Léa; Urquiza, José M.; Vrijheid, Martine; Chatzi, Leda (JAMA Network, 2020)

  IMPORTANCE: The balance of mercury risk and nutritional benefit from fish intake during pregnancy for the metabolic health of offspring to date is unknown. OBJECTIVE: To assess the associations of fish intake and mercury ...
• How to represent a word and predict it, too: improving tied architectures for language modelling

  Gulordava, Kristina; Aina, Laura; Boleda, Gemma (ACL (Association for Computational Linguistics), 2018)

  Recent state-of-the-art neural language models share the representations of words given by the input and output mappings. We propose a simple modification to these architectures that decouples the hidden state from the ...
• The pharmacological reduction of hippocampal neurogenesis attenuates the protective effects of cannabidiol on cocaine voluntary intake

  Luján, Miguel Ángel; Cantacorps, Lídia; Valverde Granados, Olga (Wiley-Blackwell, 2019)

  The administration of cannabidiol has shown promising evidence in the treatment of some neuropsychiatric disorders, including cocaine addiction. However, little information is available as to the mechanisms by which ...
• In silico, in vitro, and in vivo approaches to identify molecular players in fragile X tremor and ataxia syndrome

  Haify, Saif N.; Botta Orfila, Teresa; Hukema, Renate K.; Tartaglia, Gian Gaetano (Frontiers Media, 2020)

  Fragile X-associated tremor/ataxia syndrome (FXTAS) is a late-onset neurodegenerative monogenetic disorder affecting carriers of premutation (PM) forms of the FMR1 gene, resulting in a progressive development of tremors, ...
• MasterOfPores: A workflow for the analysis of Oxford nanopore direct RNA sequencing datasets

  Cozzuto, Luca; Liu, Huanle; Pryszcz, Leszek Piotr, 1985-; Hermoso Pulido, Antonio; Delgado-Tejedor, Anna; Ponomarenko, Julia; Novoa, Eva Maria (Frontiers Media, 2020)

  The direct RNA sequencing platform offered by Oxford Nanopore Technologies allows for direct measurement of RNA molecules without the need of conversion to complementary DNA, fragmentation or amplification. As such, it is ...
• Impersonal human reference in sign languages: introduction and questionnaire

  Barberà, Gemma; Cabredo Hofherr, Patricia (John Benjamins Publishing, 2018)

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