• Transcriptional diversity during lineage commitment of human blood progenitors

  Chen, Lu; Breschi, Alessandra, 1988-; Guigó Serra, Roderic; Palumbo, Emilio; Rendon, Augusto (American Association for the Advancement of Science (AAAS), 2014)

  Blood cells derive from hematopoietic stem cells through stepwise fating events. To characterize gene expression programs driving lineage choice, we sequenced RNA from eight primary human hematopoietic progenitor populations ...
• Absence of canonical marks of active chromatin in developmentally regulated genes

  Pérez-Lluch, Sílvia; Blanco, Enrique; Tilgner, Hagen, 1980-; Curado, Joao; Ruiz-Romero, Marina; Corominas Guiu, Montserrat; Guigó Serra, Roderic (Nature Research, 2015)

  The interplay of active and repressive histone modifications is assumed to have a key role in the regulation of gene expression. In contrast to this generally accepted view, we show that the transcription of genes temporally ...
• Advances in allergen-microarray technology for diagnosis and monitoring of allergy: The MeDALL allergen-chip

  Lupinek, Christian; Antó i Boqué, Josep Maria; Valenta, Rudolf (Elsevier, 2013)

  Allergy diagnosis based on purified allergen molecules provides detailed information regarding the individual sensitization profile of allergic patients, allows monitoring of the development of allergic disease and of the ...
• Tracking five millennia of horse management with extensive ancient genome time series

  Fages, Antoine; Kuderna, Lukas F.K.; Marquès i Bonet, Tomàs, 1975-; Serres Armero, Aitor; Orlando, Ludovic (Elsevier, 2019)

  Horse domestication revolutionized warfare and accelerated travel, trade, and the geographic expansion of languages. Here, we present the largest DNA time series for a non-human organism to date, including genome-scale ...
• Determining protein structures using deep mutagenesis

  Schmiedel, Jörn M.; Lehner, Ben, 1978- (Nature Research, 2019)

  Determining the three-dimensional structures of macromolecules is a major goal of biological research, because of the close relationship between structure and function; however, thousands of protein domains still have ...
• Strategies for integrated analysis in imaging genetics studies

  Vilor Tejedor, Natàlia, 1988-; Alemany, Silvia; Cáceres, Alejandro; Bustamante Pineda, Mariona; Pujol Martí, Jesús, 1981-; Sunyer Deu, Jordi; González Ruiz, Juan Ramón (Elsevier, 2018)

  Imaging Genetics (IG) integrates neuroimaging and genomic data from the same individual, deepening our knowledge of the biological mechanisms behind neurodevelopmental domains and neurological disorders. Although the ...
• Effect of specific over nonspecific VR-based rehabilitation on poststroke motor recovery: a systematic meta-analysis

  Maier, Martina; Rubio Ballester, Belén; Duff, Armin; Duarte Oller, Esther; Verschure, Paul F.M.J. (SAGE Publications, 2019)

  BACKGROUND: Despite the rise of virtual reality (VR)-based interventions in stroke rehabilitation over the past decade, no consensus has been reached on its efficacy. This ostensibly puzzling outcome might not be that ...
• A review of automatic rhythm description systems

  Gouyon, Fabien; Dixon, Simon (MIT Press, 2005)

  Rhythm belongs with harmony, melody and timbre as one of the most fundamental aspects of music. Sound by its very nature is temporal, and in its most generic sense, the word \textit{rhythm} is used to refer to all of the ...
• Inferring directed networks using a rank-based connectivity measure

  Leguia, Marc G.; Martínez, Cristina G. B.; Malvestio, Irene; Tauste Campo, Adrià; Rocamora, Rodrigo; Levnajić, Zoran; Andrzejak, Ralph Gregor (American Physical Society, 2019)

  Inferring the topology of a network using the knowledge of the signals of each of the interacting units is key to understanding real-world systems. One way to address this problem is using data- driven methods like ...
• Probabilistic functional tractography of the human cortex revisited

  Trebaul, Lena; Rocamora Zúñiga, Rodrigo Alberto; David, Olivier (Elsevier, 2018)

  In patients with pharmaco-resistant focal epilepsies investigated with intracranial electroencephalography (iEEG), direct electrical stimulations of a cortical region induce cortico-cortical evoked potentials (CCEP) in ...
• Capturing variation impact on molecular interactions in the IMEx Consortium mutations data set

  Del Toro, N.; Piñero González, Janet, 1977-; Furlong, Laura I., 1971-; Porras, P.; IMEx Consortium Curators (Nature Research, 2019)

  The current wealth of genomic variation data identified at nucleotide level presents the challenge of understanding by which mechanisms amino acid variation affects cellular processes. These effects may manifest as distinct ...
• Consonance processing in the absence of relevant experience: evidence from nonhuman animals

  Toro Soto, Juan Manuel, 1976-; Crespo Bojorque, Paola, 1985- (The Comparative Cognition Society, 2017)

  Consonance is a major feature in harmonic music that has been related to how pleasant a sound is perceived. Consonant chords are defined by simple frequency ratios between their composing tones, whereas dissonant chords ...
• Cognitive performance in healthy older adults relates to spontaneous switching between states of functional connectivity during rest

  Cabral, Joana R. B.; Vidaurre, Diego; Marques, Paulo; Magalhães, Ricardo; Moreira, Pedro Silva; Soares, José Miguel; Deco, Gustavo; Sousa, Nuno; Kringelbach, Morten L. (Nature Research, 2017)

  Growing evidence has shown that brain activity at rest slowly wanders through a repertoire of different states, where whole-brain functional connectivity (FC) temporarily settles into distinct FC patterns. Nevertheless, ...
• Spatial gamut mapping among non-inclusive gamuts

  Bertalmío, Marcelo; Vazquez-Corral, Javier (Elsevier, 2018)

  Gamut mapping transforms the color gamut of an image to that of a target device. Two cases are usually considered: gamut reduction (target gamut smaller than source gamut), and gamut extension (target gamut larger than ...
• Germline variation at 8q24 and prostate cancer risk in men of European ancestry

  Matejcic, Marco; Kogevinas, Manolis; Haiman, Christopher A. (Nature Research, 2018)

  Chromosome 8q24 is a susceptibility locus for multiple cancers, including prostate cancer. Here we combine genetic data across the 8q24 susceptibility region from 71,535 prostate cancer cases and 52,935 controls of European ...
• Whole-brain neuronal activity displays crackling noise dynamics

  Ponce-Alvarez, Adrián; Jouary, Adrien; Privat, Martin; Deco, Gustavo; Sumbre, Germán (Elsevier, 2018)

  Previous studies suggest that the brain operates at a critical point in which phases of order and disorder coexist, producing emergent patterned dynamics at all scales and optimizing several brain functions. Here, we ...
• CLL cells cumulate genetic aberrations prior to the first therapy even in outwardly inactive disease phase

  Hernández-Sánchez, María; Kotaskova, Jana; Rodríguez, Ana E.; Radova, Lenka; Tamborero Noguera, David; Abáigar, María; Plevova, Karla; Benito, Rocío; Tom, Nikola; Quijada-Álamo, Miguel; Bikos, Vasileos; Martín, Ana África; Pal, Karol; García de Coca, Alfonso; Doubek, Michael; López Bigas, Núria; Hernández-Rivas, Jesús María; Pospisilova, Sarka (Nature Research, 2019)
• Machine learning of coarse-grained molecular dynamics force fields

  Wang, Jiang; Olsson, Simon; Wehmeyer, Christoph; Pérez, Adrià; Charron, Nicholas E.; De Fabritiis, Gianni; Noé, Frank; Clementi, Cecilia (American Chemical Society (ACS), 2019)

  Atomistic or ab initio molecular dynamics simulations are widely used to predict thermodynamics and kinetics and relate them to molecular structure. A common approach to go beyond the time- and length-scales accessible ...
• An experimental assay of the interactions of amino acids from orthologous sequences shaping a complex fitness landscape

  Pokusaeva, Victoria O.; Usmanova, Dinara R.; Putintseva, Ekaterina V.; Espinar, Lorena; Sarkisyan, Karen S.; Mishin, Alexander S.; Bogatyreva, Natalya S.; Ivankov, Dmitry N.; Akopyan, Arseniy V.; Avvakumov, Sergey Ya; Povolotskaya, Inna, 1986-; Filion, Guillaume; Carey, Lucas; Kondrashov, Fyodor A., 1979- (Public Library of Science (PLoS), 2019)

  Characterizing the fitness landscape, a representation of fitness for a large set of genotypes, is key to understanding how genetic information is interpreted to create functional organisms. Here we determined the ...
• NACTA: construyendo el futuro de la tradición del jingju

  Caro Repetto, Rafael; Serra, Xavier (2016)

  En sus poco más de doscientos años de historia, el jingju, u ópera de Pekín, ha conseguido el título de tesoro nacional (guocui) y como tal ha asumido la turbulenta historia reciente del país. En la puja por situarse como ...

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