• Adherence to the mediterranean lifestyle and desired body weight loss in a mediterranean adult population with overweight: a PREDIMED-Plus Study

  Bouzas, Cristina; Zomeño Fajardo, Maria Dolores; Muñoz, Julia; Castañer, Olga; Goday Arno, Alberto; Tur, J. Antoni (MDPI, 2020)

  Background: Body weight dissatisfaction is a hindrance to following a healthy lifestyle and it has been associated with weight concerns. Objectives: The aim of this study was to assess the association between the adherence ...
• Association between the potential influence of a lifestyle intervention in older individuals with excess weight and metabolic syndrome on untreated household cohabitants and their family support: the PREDIMED-Plus Study

  Basora, Josep; Villalobos, Felipe; Pallejà-Millán, Meritxell; Babio, Nancy; Goday Arno, Alberto; Castañer, Olga; Fitó Colomer, Montserrat; Zomeño Fajardo, Maria Dolores; Pintó Sala, Xavier; Sacanella, Emilio; Paz-Graniel, Indira; Salas Salvadó, Jordi (MDPI, 2020)

  This cross-sectional study aims to evaluate the association between the PREDIMED-Plus study lifestyle intervention and (i) adherence to the Mediterranean diet (MedDiet) and (ii) physical activity of cohabiting study ...
• Down syndrome is a metabolic disease: altered insulin signaling mediates peripheral and brain dysfunctions

  Dierssen, Mara; Fructuoso, Marta; Martínez de Lagrán Cabredo, María; Perluigi, Marzia; Barone, Eugenio (Frontiers, 2020)

  Down syndrome (DS) is the most frequent chromosomal abnormality that causes intellectual disability, resulting from the presence of an extra complete or segment of chromosome 21 (HSA21). In addition, trisomy of HSA21 ...
• Calibrating seed-based heuristics to map short reads with sesame

  Filion, Guillaume; Cortini, Ruggero; Zorita, Eduard (Frontiers, 2020)

  The increasing throughput of DNA sequencing technologies creates a need for faster algorithms. The fate of most reads is to be mapped to a reference sequence, typically a genome. Modern mappers rely on heuristics to gain ...
• Trans-generational epigenetic regulation associated with the amelioration of Duchenne Muscular Dystrophy

  Martone, Julie; Lisi, Michela; Castagnetti, Francesco; Rosa, Alessandro; Di Carlo, Valerio; Blanco, Enrique; Setti, Adriano; Mariani, Davide; Colantoni, Alessio; Santini, Tiziana; Perone, Lucia; Di Croce, Luciano; Bozzoni, Irene (UNLISTED PUBLISHER, 2020)

  Exon skipping is an effective strategy for the treatment of many Duchenne Muscular Dystrophy (DMD) mutations. Natural exon skipping observed in several DMD cases can help in identifying novel therapeutic tools. Here, we ...
• IL18 signaling promotes homing of mature Tregs into the thymus

  Peligero Cruz, Cristina, 1986-; Givony, Tal; Sebé-Pedrós, Arnau; Dobeš, Jan; Kadouri, Noam; Nevo, Shir; Roncato, Francesco; Alon, Ronen; Goldfarb, Yael; Abramson, Jakub (eLife, 2020)

  Foxp3+ regulatory T cells (Tregs) are potent suppressor cells, essential for the maintenance of immune homeostasis. Most Tregs develop in the thymus and are then released into the immune periphery. However, some Tregs ...
• Tumor Necrosis Factor Receptor SF10A (TNFRSF10A) SNPs correlate with corticosteroid response in duchenne muscular dystrophy

  Passarelli, Chiara; Lochmüller, Hanns; Ferlini, Alessandra (Frontiers, 2020)

  Background: Duchenne muscular dystrophy (DMD) is a rare and severe X-linked muscular dystrophy in which the standard of care with variable outcome, also due to different drug response, is chronic off-label treatment with ...
• Ancient genomic regulatory blocks are a source for regulatory gene deserts in vertebrates after whole-genome duplications

  Touceda-Suárez, María; Kita, Elizabeth M.; Acemel, Rafael D.; Firbas, Panos N.; Magri, Marta S.; Naranjo, Silvia; Tena, Juan J.; Gómez Skarmeta, José Luis; Maeso, Ignacio; Irimia, Manuel (Oxford University Press (OUP), 2020)

  We investigated how the two rounds of whole-genome duplication that occurred at the base of the vertebrate lineage have impacted ancient microsyntenic associations involving developmental regulators (known as genomic ...
• Selection following gene duplication shapes recent genome evolution in the pea aphid acyrthosiphon pisum

  Fernández, Rosa; Marcet Houben, Marina; Legeai, Fabrice; Richard, Gautier; Robin, Stéphanie; Wucher, Valentin; Pegueroles Queralt, Maria Cinta; Gabaldón Estevan, Juan Antonio, 1973-; Tagu, Denis (Oxford University Press (OUP), 2020)

  Ecology of insects is as wide as their diversity, which reflects their high capacity of adaptation in most of the environments of our planet. Aphids, with over 4,000 species, have developed a series of adaptations including ...
• Identification of enhancer-promoter contacts in embryoid bodies by quantitative chromosome conformation capture (4C)

  Tian, Tian V.; Vidal Ocabo, Enrique; Graf, T. (Thomas); Stik, Grégoire (MyJove Corporation, 2020)

  During mammalian development, cell fates are determined through the establishment of regulatory networks that define the specificity, timing, and spatial patterns of gene expression. Embryoid bodies (EBs) derived from ...
• Non-experts or experts? Statistical analyses of MOS using DSIS method

  Sugito, Yasuko; Bertalmío, Marcelo (Institute of Electrical and Electronics Engineers (IEEE), 2020)

  In image quality assessments, the results of subjective evaluation experiments that use the double-stimulus impairment scale (DSIS) method are often expressed in terms of the mean opinion score (MOS), which is the average ...
• Practical use suggests a re-evaluation of HDR objective quality metrics

  Sugito, Yasuko; Bertalmío, Marcelo (Institute of Electrical and Electronics Engineers (IEEE), 2019)

  Full-reference objective quality metrics for high dynamic range (HDR) images must be validated in terms of their consistency with subjective evaluation results, and previous studies have found a number of metrics that ...
• In-camera, photorealistic style transfer for on-set automatic grading

  Zabaleta, Itziar; Bertalmío, Marcelo (Society of Motion Picture and Television Engineers (SMPTE), 2018)

  In professional cinema, the intended artistic look of the movie informs the creation of a static 3D LUT that is applied on set, where further manual modifications to the image appearance are registered as 10-parameter ...
• HOTAIRM1 regulates neuronal differentiation by modulating NEUROGENIN 2 and the downstream neurogenic cascade

  Rea, Jessica; Menci, Valentina; Tollis, Paolo; Santini, Tiziana; Armaos, Alexandros, 1989-; Garone, Maria Giovanna; Iberite, Federica; Cipriano, Andrea; Tartaglia, Gian Gaetano; Rosa, Alessandro; Ballarino, Monica; Laneve, Pietro; Caffarelli, Elisa (Nature Research, 2020)

  Neuronal differentiation is a timely and spatially regulated process, relying on precisely orchestrated gene expression control. The sequential activation/repression of genes driving cell fate specification is achieved by ...
• Color stabilization for multi-camera light-field imaging

  Vu-Thanh, Olivier; Canham, Trevor; Vazquez-Corral, Javier; Gil Rodríguez, Raquel; Bertalmío, Marcelo (Institute of Electrical and Electronics Engineers (IEEE), 2020)

  By capturing a more complete rendition of scene light than standard 2D cameras, light-field technology represents an important step towards closing the gap between live action cinematography and computer graphics. Light-field ...
• Transcriptomic differences in MSA clinical variants

  Pérez Soriano, Alexandra; Arnal, Magdalena; Botta Orfila, Teresa; Giraldo, Darly; Fernández, Manel; Compta, Yaroslau; Fernández-Santiago, Ruben; Ezquerra, Mario; Tartaglia, Gian Gaetano; Martí, M. Josep; Catalan multiple system atrophy-registry (CMSAR) (Nature Research, 2020)

  Background: Multiple system atrophy (MSA) is a rare oligodendroglial synucleinopathy of unknown etiopathogenesis including two major clinical variants with predominant parkinsonism (MSA-P) or cerebellar dysfunction (MSA-C). ...
• Characterization of different alginate lyases for dissolving Pseudomonas aeruginosa biofilms

  Blanco Cabra, Núria; Paetzold, Bernhard, 1981-; Ferrar, Tony; Mazzolini, Rocco; Torrents, Eduard; Serrano Pubull, Luis, 1982-; Lluch-Senar, Maria 1982- (Nature Research, 2020)

  Aggregates of Pseudomonas aeruginosa form a protective barrier against antibiotics and the immune system. These barriers, known as biofilms, are associated with several infectious diseases. One of the main components of ...
• Plasma-derived extracellular vesicles from Plasmodium vivax patients signal spleen fibroblasts via NF-kB facilitating parasite cytoadherence

  Toda, Haruka; Borràs, Eva; Sabidó Aguadé, Eduard, 1981-; del Portillo, Hernando A. (Nature Research, 2020)

  Plasmodium vivax is the most widely distributed human malaria parasite. Previous studies have shown that circulating microparticles during P. vivax acute attacks are indirectly associated with severity. Extracellular ...
• The protective role of m1A during stress-induced granulation

  Alriquet, Marion; Calloni, Giulia; Martínez Limón, Adrián; Delli Ponti, Riccardo, 1987-; Hanspach, Gerd; Hegensbach, Martin; Tartaglia, Gian Gaetano; Vabulas, R. Martin (Oxford University Press (OUP), 2020)

  Post-transcriptional methylation of N6- and N1-adenine can effect transcriptome turnover and translation. Furthermore, the regulatory function of N6-methyladenine (m6A) during heat shock has been uncovered, including the ...
• Sampling time-dependent artifacts in single-cell genomics studies

  Massoni-Badosa, Ramon; Iacono, Giovanni; Moutinho, Catia; Kulis, Marta; Palau, Núria; Marchese, Domenica, 1986-; Rodríguez Ubreva, Javier; Ballestar, Esteban; Rodríguez Esteban, Gustavo; Marsal, Sara; Aymerich, Marta; Colomer, Dolors; Campo, Elias; Julià Cano, Antoni; Martín-Subero, José I.; Heyn, Holger (BioMed Central, 2020)

  Robust protocols and automation now enable large-scale single-cell RNA and ATAC sequencing experiments and their application on biobank and clinical cohorts. However, technical biases introduced during sample acquisition ...

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