• Role of cannabinoids in alcohol-induced neuroinflammation

  García Baos, Alba; Alegre Zurano, Laia; Cantacorps Centellas, Lídia, 1991-; Martín Sánchez, Ana; Valverde Granados, Olga (Elsevier, 2021)

  Alcohol is a psychoactive substance highly used worldwide, whose harmful use might cause a broad range of mental and behavioural disorders. Underlying brain impact, the neuroinflammatory response induced by alcohol is ...
• STAG2 loss-of-function affects short-range genomic contacts and modulates the basal-luminal transcriptional program of bladder cancer cells

  Richart, Laia; Lapi, Eleonora; Pancaldi, Vera; Cuenca-Ardura, Mirabai; Carrillo-de-Santa Pau, Enrique; Madrid-Mencía, Miguel; Neyret-Kahn, Hélène; Radvanyi, François; Rodríguez, Juan Antonio; Cuartero, Yasmina; Serra, François; Le Dily, François; Valencia, Alfonso; Martí Renom, Marc A.; Real, Francisco X. (Oxford University Press, 2021)

  Cohesin exists in two variants containing STAG1 or STAG2. STAG2 is one of the most mutated genes in cancer and a major bladder tumor suppressor. Little is known about how its inactivation contributes to tumorigenesis. Here, ...
• Find and cut-and-transfer (FiCAT) mammalian genome engineering

  Pallarès-Masmitjà, Maria; Ivančić, Dimitrije; Mir-Pedrol, Júlia; Jaraba-Wallace, Jessica; Tagliani, Tommaso; Oliva Miguel, Baldomero; Rahmeh, Amal; Sánchez-Mejías, Avencia; Güell Cargol, Marc (Nature Research, 2021)

  While multiple technologies for small allele genome editing exist, robust technologies for targeted integration of large DNA fragments in mammalian genomes are still missing. Here we develop a gene delivery tool (FiCAT) ...
• Entrectinib-A SARS-CoV-2 inhibitor in Human Lung Tissue (HLT) cells

  Peralta-Garcia, Alejandro; Torrens Fontanals, Mariona; Stepniewski, Tomasz Maciej, 1988-; Grau-Expósito, Judith; Perea, David; Ayinampudi, Vikram; Waldhoer, Maria; Zimmermann, Mirjam; Buzón, María J.; Genescà, Meritxell; Selent, Jana (MDPI, 2021)

  Since the start of the COVID-19 outbreak, pharmaceutical companies and research groups have focused on the development of vaccines and antiviral drugs against SARS-CoV-2. Here, we apply a drug repurposing strategy to ...
• Long-term evolution of the adaptive NKG2C + NK cell response to cytomegalovirus infection in kidney transplantation: an insight on the diversity of host-pathogen interaction

  Ataya Fernández, Michelle, 1993-; Redondo Pachón, María Dolores; Llinàs-Mallol, Laura; Yélamos López, José; Alari-Pahissa, Elisenda; Pérez-Sáez, María José; Altadill, Mireia; Raïch-Regué, Dàlia; Vilches, Carlos; Pascual Santos, Julio; Crespo Barrio, Marta; López-Botet, Miguel (American Association of Immunologists - AAI, 2021)

  Human CMV infection is frequent in kidney transplant recipients (KTR). Pretransplant Ag-specific T cells and adaptive NKG2C+ NK cells associate with reduced incidence of infection in CMV+ KTR. Expansions of adaptive NKG2C+ ...
• Population history of North Africa based on modern and ancient genomes

  Lucas-Sánchez, Marcel; Serradell, Jose M.; Comas, David, 1969- (Oxford University Press, 2021)

  Compared with the rest of the African continent, North Africa has provided limited genomic data. Nonetheless, the genetic data available show a complex demographic scenario characterized by extensive admixture and drift. ...
• The landscape of somatic mutation in cerebral cortex of autistic and neurotypical individuals revealed by ultra-deep whole-genome sequencing

  Rodin, Rachel E.; Brain Somatic Mosaicism Network; Walsh, Christopher A. (Nature Research, 2021)

  We characterize the landscape of somatic mutations-mutations occurring after fertilization-in the human brain using ultra-deep (~250×) whole-genome sequencing of prefrontal cortex from 59 donors with autism spectrum disorder ...
• Maximizing the acquisition of unique reads in noninvasive capture sequencing experiments

  Fontseré Alemany, Clàudia, 1992-; Alvarez-Estape, Marina; Kuhlwilm, Martin; Marquès i Bonet, Tomàs, 1975-; Lizano González, Esther, 1974- (Wiley, 2021)

  Noninvasive samples as a source of DNA are gaining interest in genomic studies of endangered species. However, their complex nature and low endogenous DNA content hamper the recovery of good quality data. Target capture ...
• The dental proteome of Homo antecessor

  Welker, Frido; Chiva, Cristina; Kuhlwilm, Martin; Manuel Montero, Marc de, 1991-; Gelabert Xirinachs, Pere, 1991-; Marquès i Bonet, Tomàs, 1975-; Sabidó Aguadé, Eduard, 1981-; Lalueza Fox, Carles, 1965-; Cappellini, Enrico (Nature Research, 2020)

  The phylogenetic relationships between hominins of the Early Pleistocene epoch in Eurasia, such as Homo antecessor, and hominins that appear later in the fossil record during the Middle Pleistocene epoch, such as Homo ...
• The human sperm basal body is a complex centrosome important for embryo preimplantation development

  Amargant i Riera, Farners, 1990-; Pujol, Aïda; Ferrer-Vaquer, Anna; Durban, Mercè; Martínez, Meritxell; Vassena, Rita; Vernos, Isabelle, 1959- (Oxford University Press, 2021)

  The mechanism of conversion of the human sperm basal body to a centrosome after fertilization, and its role in supporting human early embryogenesis, has not been directly addressed so far. Using proteomics and immunofluorescence ...
• IonoBiology: The functional dynamics of the intracellular metallome, with lessons from bacteria

  Galera Laporta, Letícia, 1985-; Comerci, Colin J.; García Ojalvo, Jordi; Süel, Gürol M. (Elsevier, 2021)

  Metal ions are essential for life and represent the second most abundant constituent (after water) of any living cell. While the biological importance of inorganic ions has been appreciated for over a century, we are far ...
• Species-specific segmentation clock periods are due to differential biochemical reaction speeds

  Matsuda, Mitsuhiro; Hayashi, Hanako; García Ojalvo, Jordi; Yoshioka-Kobayashi, Kumiko; Kageyama, Ryoichiro; Yamanaka, Yoshihiro; Ikeya, Makoto; Toguchida, Junya; Alev, Cantas; Ebisuya, Miki (American Association for the Advancement of Science (AAAS), 2020)

  Although mechanisms of embryonic development are similar between mice and humans, the time scale is generally slower in humans. To investigate these interspecies differences in development, we recapitulate murine and human ...
• Soft-wired long-term memory in a natural recurrent neuronal network

  Casal, Miguel A.; Galella Toledo, Santiago; Vilarroya, Óscar; García Ojalvo, Jordi (American Institute of Physics (AIP), 2020)

  Recurrent neuronal networks are known to be endowed with fading (short-term) memory, whereas long-term memory is usually considered to be hard-wired in the network connectivity via Hebbian learning, for instance. Here, we ...
• Encoding membrane-potential-based memory within a microbial community

  Yang, Chih-Yu; Bialecka-Fornal, Maja; Weatherwax, Colleen; Larkin, Joseph; Prindle, Arthur; Liu, Jintao; García Ojalvo, Jordi; Süel, Gürol M. (Elsevier, 2020)

  Cellular membrane potential plays a key role in the formation and retrieval of memories in the metazoan brain, but it remains unclear whether such memory can also be encoded in simpler organisms like bacteria. Here, we ...
• Genomic insight into the origins and dispersal of the Brazilian coastal natives

  Castro e Silva, Marcos Araújo; Nunes, Kelly; Barbosa Lemes, Renan; Mas Sandoval, Àlex, 1989-; Guerra Amorim, Carlos Eduardo; Krieger, José Eduardo; Mill, José Geraldo; Salzano, Francisco Mauro; Bortolini, Maria Cátira; Pereira, Alexandre da Costa; Comas, David, 1969-; Hünemeier, Tábita (National Academy of Sciences, 2020)

  In the 15th century, ∼900,000 Native Americans, mostly Tupí speakers, lived on the Brazilian coast. By the end of the 18th century, the coastal native populations were declared extinct. The Tupí arrived on the east coast ...
• Establishing a cell-free transcription-translation platform for Cutibacterium acnes to prototype engineered metabolic and synthetic biology

  Fábrega, María José; Knödlseder, Nastassia; Nevot, Guillermo; Sanvicente, Marta; Toloza, Lorena; Santos-Moreno, Javier; Güell Cargol, Marc (American Chemical Society (ACS), 2021)

  In the past few years, new bacterial-cell-free transcription-translation systems have emerged as potent and quick platforms for protein production as well as for prototyping of DNA regulatory elements, genetic circuits, ...
• PlayMolecule glimpse: understanding protein-ligand property predictions with interpretable neural networks

  Varela-Rial, Alejandro; Maryanow, Iain; Majewski, Maciej; Doerr, Stefan, 1987-; Schapin, Nikolai; Jiménez Luna, José, 1993-; De Fabritiis, Gianni (American Chemical Society (ACS), 2022)

  Deep learning has been successfully applied to structure-based protein-ligand affinity prediction, yet the black box nature of these models raises some questions. In a previous study, we presented KDEEP, a convolutional ...
• Rationally modified antimicrobial peptides from the N-terminal domain of human RNase 3 show exceptional serum stability

  Sandín, Daniel; Valle, Javier; Chaves-Arquero, Belén; Prats-Ejarque, Guillem; Larrosa, María Nieves; González-López, Juan José; Jiménez, María Ángeles; Boix, Ester; Andreu Martínez, David; Torrent Burgas, Marc (American Chemical Society (ACS), 2021)

  Multidrug resistance against conventional antibiotics poses an important threat to human health. In this context, antimicrobial peptides (AMPs) have been extensively studied for their antibacterial activity and promising ...
• Penetrating the blood-brain barrier with new peptide-porphyrin conjugates having anti-HIV activity

  Mendonça, Diogo A.; Bakker, Mariët; Cruz-Oliveira, Christine; Neves, Vera; Jiménez, Maria Angeles; Defaus, Sira; Cavaco, Marco; Salomé Veiga, Ana; Cadima-Couto, Iris; Castanho, Miguel A.R.B.; Andreu Martínez, David; Todorovski, Toni (American Chemical Society (ACS), 2021)

  Passing through the blood-brain barrier (BBB) to treat neurological conditions is one of the main hurdles in modern medicine. Many drugs with promising in vitro profiles become ineffective in vivo due to BBB restrictive ...
• Orally active peptide vector allows using cannabis to fight pain while avoiding side effects

  Gallo, Maria; Moreno, Estefanía; Defaus, Sira; Ortega Alvaro, Antonio; Gonzalez, Angel; Robledo, Patricia, 1958-; Cavaco, Marco; Neves, Vera; Castanho, Miguel A.R.B.; Casadó, Vicent; Pardo Carrasco, Leonardo; Maldonado, Rafael, 1961-; Andreu Martínez, David (American Chemical Society (ACS), 2021)

  The activation of cannabinoid CB1 receptors (CB1R) by Δ9-tetrahydrocannabinol (THC), the main component of Cannabis sativa, induces analgesia. CB1R activation, however, also causes cognitive impairment via the serotonin ...

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