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Water intake, hydration status and 2-year changes in cognitive performance: a prospective cohort study

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dc.contributor.author Nishi, Stephanie
dc.contributor.author Fitó Colomer, Montserrat
dc.contributor.author Castañer, Olga
dc.contributor.author Salas-Salvadó, Jordi
dc.date.accessioned 2024-02-13T09:20:52Z
dc.date.available 2024-02-13T09:20:52Z
dc.date.issued 2023
dc.identifier.citation Nishi SK, Babio N, Paz-Graniel I, Serra-Majem L, Vioque J, Fitó M, et al. Water intake, hydration status and 2-year changes in cognitive performance: a prospective cohort study. BMC Med. 2023 Mar 8;21(1):82. DOI: 10.1186/s12916-023-02771-4
dc.identifier.issn 1741-7015
dc.identifier.uri http://hdl.handle.net/10230/59094
dc.description.abstract Background Water intake and hydration status have been suggested to impact cognition; however, longitudinal evidence is limited and often inconsistent. This study aimed to longitudinally assess the association between hydration status and water intake based on current recommendations, with changes in cognition in an older Spanish population at high cardiovascular disease risk. Methods A prospective analysis was conducted of a cohort of 1957 adults (aged 55–75) with overweight/obesity (BMI between ≥ 27 and < 40 kg/m2) and metabolic syndrome from the PREDIMED-Plus study. Participants had completed bloodwork and validated, semiquantitative beverage and food frequency questionnaires at baseline, as well as an extensive neuropsychological battery of 8 validated tests at baseline and 2 years of follow-up. Hydration status was determined by serum osmolarity calculation and categorized as < 295 mmol/L (hydrated), 295–299.9 mmol/L (impending dehydration), and ≥ 300 mmol/L (dehydrated). Water intake was assessed as total drinking water intake and total water intake from food and beverages and according to EFSA recommendations. Global cognitive function was determined as a composite z-score summarizing individual participant results from all neuropsychological tests. Multivariable linear regression models were fitted to assess the associations between baseline hydration status and fluid intake, continuously and categorically, with 2-year changes in cognitive performance. Results The mean baseline daily total water intake was 2871 ± 676 mL/day (2889 ± 677 mL/day in men; 2854 ± 674 mL/day in women), and 80.2% of participants met the ESFA reference values for an adequate intake. Serum osmolarity (mean 298 ± 24 mmol/L, range 263 to 347 mmol/L) indicated that 56% of participants were physiologically dehydrated. Lower physiological hydration status (i.e., greater serum osmolarity) was associated with a greater decline in global cognitive function z-score over a 2-year period (β: − 0.010; 95% CI − 0.017 to − 0.004, p-value = 0.002). No significant associations were observed between water intake from beverages and/or foods with 2-year changes in global cognitive function. Conclusions Reduced physiological hydration status was associated with greater reductions in global cognitive function over a 2-year period in older adults with metabolic syndrome and overweight or obesity. Future research assessing the impact of hydration on cognitive performance over a longer duration is needed. Trial registration International Standard Randomized Controlled Trial Registry, ISRCTN89898870. Retrospectively registered on 24 July 2014
dc.description.sponsorship This work was supported by the official Spanish Institutions for funding scientific biomedical research, CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN) and Instituto de Salud Carlos III (ISCIII), through the Fondo de Investigación para la Salud (FIS), which is co-funded by the European Regional Development Fund (six coordinated FIS projects leaded by JS-S and JVi, including the following projects: PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374, PI14/00972, PI14/00728, PI14/01471, PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183, PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215, PI17/01441, PI17/00508, PI17/01732, PI17/00926, PI19/00957, PI19/00386, PI19/00309, PI19/01032, PI19/00576, PI19/00017, PI19/01226, PI19/00781, PI19/01560, PI19/01332, PI20/01802, PI20/00138, PI20/01532, PI20/00456, PI20/00339, PI20/00557, PI20/00886, PI20/01158); the Especial Action Project entitled: Implementación y evaluación de una intervención intensiva sobre la actividad física Cohorte PREDIMED-Plus grant to JS-S; the European Research Council (Advanced Research Grant 2014–2019; agreement #340918) granted to MÁM-G.; the Recercaixa (number 2013ACUP00194) grant to JS-S; grants from the Consejería de Salud de la Junta de Andalucía (PI0458/2013, PS0358/2016, PI0137/2018); the PROMETEO 17/2017 and PROMETEO 21/2021 grant from the Generalitat Valenciana; the SEMERGEN grant; and the Juan de la Cierva-Incorporación research grant (IJC2019-042420-I) of the Spanish Ministry of Economy, Industry and Competitiveness and European Social Funds. This research was also partially funded by EU-H2020 Grants (Eat2beNICE/H2020-SFS-2016-2) and the Horizon 2020 PRIME study (Prevention and Remediation of Insulin Multimorbidity in Europe; grant agreement #847879). S.K.N. is supported by a postdoctoral fellowship from the Canadian Institutes of Health Research (CIHR, MFE-171207). CG-M is supported by a predoctoral grant from the University of Rovira I Virgili (2020PMF-PIPF-37). IP-G is supported by a predoctoral grant from Ministerio de Ciencia, Innovación y Universidades (FPU 17/01925). AA-S has received a post-doctoral grant (APOSTD/2020/164) from the Consellería de Innovación, Ciencia y Sociedad Digital, Generalitat Valenciana, Fondo Social Europeo-FSE. CB is supported by a Juan de la Cierva postdoctoral grant from Ministerio de Ciencia, Innovación y Universidades. JS-S, the senior author of this paper, was partially supported by ICREA under the ICREA Academia program. Publication of this work is supported by a conference award grant from Hydration for Health presented by the Danone Global Research & Innovation Center (#2022-08514) awarded to S.K.N. for being the conference attendee voted recipient of the Early Career Researcher Award. None of the funding sources took part in the design, collection, analysis, interpretation of the data; writing of the report; or the decision to submit the manuscript for publication.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher BioMed Central
dc.relation.ispartof BMC Med. 2023 Mar 8;21(1):82
dc.rights © The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Water intake, hydration status and 2-year changes in cognitive performance: a prospective cohort study
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1186/s12916-023-02771-4
dc.subject.keyword Cognition
dc.subject.keyword Cognitive function
dc.subject.keyword Cognitive performance
dc.subject.keyword Fluids
dc.subject.keyword Hydration
dc.subject.keyword PREDIMED-plus
dc.subject.keyword Serum osmolality
dc.subject.keyword Serum osmolarity
dc.subject.keyword Water
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/340918
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/847879
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/728018
dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/IJC2019-042420-I
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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