Welcome to the UPF Digital Repository

The natural history of QTc interval and its clinical impact in coronavirus disease 2019 survivors after 1 year

Show simple item record

dc.contributor.author Mojón Álvarez, Diana
dc.contributor.author Izquierdo, Andrea
dc.contributor.author Cubero Gallego, Héctor
dc.contributor.author Calvo-Fernández, Alicia
dc.contributor.author Marrugat de la Iglesia, Jaume
dc.contributor.author Pérez-Fernández, Silvia
dc.contributor.author Cabero, Paula
dc.contributor.author Solà-Richarte, Clàudia
dc.contributor.author Soler, Cristina
dc.contributor.author Farré López, Núria
dc.contributor.author Vaquerizo Montilla, Beatriz
dc.date.accessioned 2023-09-18T06:24:29Z
dc.date.available 2023-09-18T06:24:29Z
dc.date.issued 2023
dc.identifier.citation Mojón-Álvarez D, Izquierdo A, Cubero-Gallego H, Calvo-Fernández A, Marrugat J, Pérez-Fernández S, Cabero P, Solà-Richarte C, Soler C, Farré N, Vaquerizo B. The natural history of QTc interval and its clinical impact in coronavirus disease 2019 survivors after 1 year. Front Cardiovasc Med. 2023;10:1140276. DOI: 10.3389/fcvm.2023.1140276
dc.identifier.issn 2297-055X
dc.identifier.uri http://hdl.handle.net/10230/57900
dc.description.abstract Background and objective: Prolonged QTc interval on admission and a higher risk of death in SARS-CoV-2 patients have been reported. The long-term clinical impact of prolonged QTc interval is unknown. This study examined the relationship in COVID-19 survivors of a prolonged QTc on admission with long-term adverse events, changes in QTc duration and its impact on 1-year prognosis, and factors associated with a prolonged QTc at follow-up. Methods: We conducted a single-center prospective cohort study of 523 SARS-CoV-2-positive patients who were alive on discharge. An electrocardiogram was taken on these patients within the first 48 h after diagnosis and before the administration of any medication with a known effect on QT interval and repeated in 421 patients 7 months after discharge. Mortality, hospital readmission, and new arrhythmia rates 1 year after discharge were reviewed. Results: Thirty-one (6.3%) survivors had a baseline prolonged QTc. They were older, had more cardiovascular risk factors, cardiac disease, and comorbidities, and higher levels of terminal pro-brain natriuretic peptide. There was no relationship between prolonged QTc on admission and the 1-year endpoint (9.8% vs. 5.5%, p = 0.212). In 84% of survivors with prolonged baseline QTc, it normalized at 7.9 ± 2.2 months. Of the survivors, 2.4% had prolonged QTc at follow-up, and this was independently associated with obesity, ischemic cardiomyopathy, chronic obstructive pulmonary disease, and cancer. Prolonged baseline QTc was not independently associated with the composite adverse event at 1 year.Conclusions: Prolonged QTc in the acute phase normalized in most COVID-19 survivors and had no clinical long-term impact. Prolonged QTc at follow-up was related to the presence of obesity and previously acquired chronic diseases and was not related to 1-year prognosis.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Frontiers
dc.relation.ispartof Front Cardiovasc Med. 2023;10:1140276
dc.rights © 2023 Mojón-Álvarez, Izquierdo, CuberoGallego, Calvo-Fernández, Marrugat, PérezFernández, Cabero, Solà-Richarte, Soler, Farré and Vaquerizo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title The natural history of QTc interval and its clinical impact in coronavirus disease 2019 survivors after 1 year
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.3389/fcvm.2023.1140276
dc.subject.keyword COVID-19
dc.subject.keyword QTc interval
dc.subject.keyword Arrhythmia
dc.subject.keyword Electrocardiogram (ECG)
dc.subject.keyword Mortality
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


This item appears in the following Collection(s)

Show simple item record

Search DSpace

Advanced Search


My Account


Compliant to Partaking