dc.contributor.author |
Prieto-Botella, Daniel |
dc.contributor.author |
Martens, Dries S. |
dc.contributor.author |
Valera-Gran, Desirée |
dc.contributor.author |
Subiza-Pérez, Mikel |
dc.contributor.author |
Tardón, Adonina |
dc.contributor.author |
Lozano Relaño, Manuel |
dc.contributor.author |
Casas, Maribel |
dc.contributor.author |
Bustamante Pineda, Mariona |
dc.contributor.author |
Jimeno-Romero, Alba |
dc.contributor.author |
Fernández-Somoano, Ana |
dc.contributor.author |
Llop, Sabrina |
dc.contributor.author |
Vrijheid, Martine |
dc.contributor.author |
Nawrot, Tim S. |
dc.contributor.author |
Navarrete-Muñoz, Eva-María |
dc.date.accessioned |
2023-06-20T06:23:13Z |
dc.date.available |
2023-06-20T06:23:13Z |
dc.date.issued |
2023 |
dc.identifier.citation |
Prieto-Botella D, Martens DS, Valera-Gran D, Subiza-Pérez M, Tardón A, Lozano M, et al. Sedentary behaviour and telomere length shortening during early childhood: evidence from the multicentre prospective INMA Cohort Study. IJERPH. 2023 Mar 2;20(6):5134. DOI: 10.3390/ijerph20065134 |
dc.identifier.issn |
1661-7827 |
dc.identifier.uri |
http://hdl.handle.net/10230/57255 |
dc.description.abstract |
Sedentary behaviour (SB) may be related to telomere length (TL) attrition due to a possible pro-inflammatory effect. This study examined the association between parent-reported sedentary behaviour (SB) and leukocyte TL at the age of 4 and telomere tracking from 4 to 8 years. In the Spanish birth cohort Infancia y Medio Ambiente (INMA) project, we analysed data from children who attended follow-up visits at age 4 (n = 669) and 8 (n = 530). Multiple robust regression models were used to explore the associations between mean daily hours of SB (screen time, other sedentary activities, and total SB) at 4 years categorised into tertiles and TL at 4 years and difference in TL rank between age 4 and 8, respectively. At the age of 4, the results showed that children with the highest screen time (1.6–5.0 h/day) had a shorter TL of −3.9% (95% CI: −7.4, −0.4; p = 0.03) compared with children in the lowest tertile (0.0–1.0 h/day). Between 4 and 8 years, a higher screen time (highest tertile group vs. lowest tertile) was associated with a decrease in the LTL rank of −1.9% (95% CI: −3.8, −0.1; p = 0.03) from 4 to 8 years. Children exposed to a higher screen time at 4 years were more prone to have shorter TL at 4 and between 4 and 8 years of age. This study supports the potential negative effect of SB during childhood on cellular longevity. |
dc.format.mimetype |
application/pdf |
dc.language.iso |
eng |
dc.publisher |
MDPI |
dc.relation.ispartof |
International Journal of Environmental Research and Public Health. 2023 Mar 2;20(6):5134 |
dc.rights |
© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
dc.rights.uri |
http://creativecommons.org/licenses/by/4.0/ |
dc.title |
Sedentary behaviour and telomere length shortening during early childhood: evidence from the multicentre prospective INMA Cohort Study |
dc.type |
info:eu-repo/semantics/article |
dc.identifier.doi |
http://dx.doi.org/10.3390/ijerph20065134 |
dc.subject.keyword |
Lifestyle |
dc.subject.keyword |
Children |
dc.subject.keyword |
Genetics |
dc.subject.keyword |
Screen time |
dc.subject.keyword |
Epigenetics |
dc.subject.keyword |
Cellular longevity |
dc.rights.accessRights |
info:eu-repo/semantics/openAccess |
dc.type.version |
info:eu-repo/semantics/publishedVersion |