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Sedentary behaviour and telomere length shortening during early childhood: evidence from the multicentre prospective INMA Cohort Study

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dc.contributor.author Prieto-Botella, Daniel
dc.contributor.author Martens, Dries S.
dc.contributor.author Valera-Gran, Desirée
dc.contributor.author Subiza-Pérez, Mikel
dc.contributor.author Tardón, Adonina
dc.contributor.author Lozano Relaño, Manuel
dc.contributor.author Casas, Maribel
dc.contributor.author Bustamante Pineda, Mariona
dc.contributor.author Jimeno-Romero, Alba
dc.contributor.author Fernández-Somoano, Ana
dc.contributor.author Llop, Sabrina
dc.contributor.author Vrijheid, Martine
dc.contributor.author Nawrot, Tim S.
dc.contributor.author Navarrete-Muñoz, Eva-María
dc.date.accessioned 2023-06-20T06:23:13Z
dc.date.available 2023-06-20T06:23:13Z
dc.date.issued 2023
dc.identifier.citation Prieto-Botella D, Martens DS, Valera-Gran D, Subiza-Pérez M, Tardón A, Lozano M, et al. Sedentary behaviour and telomere length shortening during early childhood: evidence from the multicentre prospective INMA Cohort Study. IJERPH. 2023 Mar 2;20(6):5134. DOI: 10.3390/ijerph20065134
dc.identifier.issn 1661-7827
dc.identifier.uri http://hdl.handle.net/10230/57255
dc.description.abstract Sedentary behaviour (SB) may be related to telomere length (TL) attrition due to a possible pro-inflammatory effect. This study examined the association between parent-reported sedentary behaviour (SB) and leukocyte TL at the age of 4 and telomere tracking from 4 to 8 years. In the Spanish birth cohort Infancia y Medio Ambiente (INMA) project, we analysed data from children who attended follow-up visits at age 4 (n = 669) and 8 (n = 530). Multiple robust regression models were used to explore the associations between mean daily hours of SB (screen time, other sedentary activities, and total SB) at 4 years categorised into tertiles and TL at 4 years and difference in TL rank between age 4 and 8, respectively. At the age of 4, the results showed that children with the highest screen time (1.6–5.0 h/day) had a shorter TL of −3.9% (95% CI: −7.4, −0.4; p = 0.03) compared with children in the lowest tertile (0.0–1.0 h/day). Between 4 and 8 years, a higher screen time (highest tertile group vs. lowest tertile) was associated with a decrease in the LTL rank of −1.9% (95% CI: −3.8, −0.1; p = 0.03) from 4 to 8 years. Children exposed to a higher screen time at 4 years were more prone to have shorter TL at 4 and between 4 and 8 years of age. This study supports the potential negative effect of SB during childhood on cellular longevity.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher MDPI
dc.relation.ispartof International Journal of Environmental Research and Public Health. 2023 Mar 2;20(6):5134
dc.rights © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Sedentary behaviour and telomere length shortening during early childhood: evidence from the multicentre prospective INMA Cohort Study
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.3390/ijerph20065134
dc.subject.keyword Lifestyle
dc.subject.keyword Children
dc.subject.keyword Genetics
dc.subject.keyword Screen time
dc.subject.keyword Epigenetics
dc.subject.keyword Cellular longevity
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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