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Health associations of liver enzymes and inflammatory scores with urinary citrus flavonoid metabolites

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dc.contributor.author Bullón Vela, María Vanessa
dc.contributor.author Fitó Colomer, Montserrat
dc.contributor.author Blanchart, Gemma
dc.contributor.author Martínez, José Alfredo
dc.date.accessioned 2023-03-31T06:07:56Z
dc.date.available 2023-03-31T06:07:56Z
dc.date.issued 2023
dc.identifier.citation Bullón-Vela V, Xu Y, Razquin C, Abete I, Zulet MA, Martínez-González MA, wt al. Health associations of liver enzymes and inflammatory scores with urinary citrus flavonoid metabolites. Food Funct. 2023 Jan 23;14(2):1011-23. DOI: 10.1039/d2fo02846h
dc.identifier.issn 2042-6496
dc.identifier.uri http://hdl.handle.net/10230/56389
dc.description.abstract Background: Dietary flavonoid intake is associated with a reduced risk of some cardiometabolic disorders, attributed in part to their claimed anti-inflammatory activity. Our aim was to investigate the potential association between specific urine flavonoid metabolites, liver enzymes, and inflammatory status in individuals with metabolic syndrome (MetS). Methods: In this cross-sectional study, clinical and dietary data from 267 participants, aged 55 to 75 years, participating in the PREDIMED Plus study (PREvención con DIeta MEDiterránea) were analyzed. At the baseline, spot urine samples were collected and seven urinary flavonoid metabolites were quantified using ultra-performance liquid chromatography coupled to triple quadrupole mass spectrometry (UPLC-Q-q-Q MS). Liver enzymes, inflammatory scores, and urinary flavonoid concentrations were inverse normally transformed. Results: Adjusted linear regression models showed an inverse association between urinary citrus flavanone concentrations and gamma-glutamyl transferase (GGT) (all p-values <0.05). Naringenin 7'-GlcUA was significantly associated with a lower aggregate index of systemic inflammation (AISI) (Bper 1SD = -0.14; 95% CI: -0.27 to -0.02; p-value = 0.025) and systemic inflammation index (SII) (Bper 1SD = -0.14; 95% CI: -0.27 to -0.02; p-value = 0.028). To investigate the relationship between flavanone subclasses and GGT levels, we fitted a score of citrus-flavanones, and subjects were stratified into quartiles. The highest values of the citrus-flavanone score (per 1-SD increase) were associated with lower GGT levels (Bper 1SD = -0.41; 95% CI: -0.74 to -0.07), exhibiting a linear trend across quartiles (p-trend = 0.015). Conclusion: This cross-sectional study showed that higher urinary excretion of citrus-flavanone metabolites was associated with lower GGT levels in subjects diagnosed with MetS and obesity.
dc.description.sponsorship The PREDIMED-Plus trial was supported by the European Research Council (Advanced Research grant 2014–2019; agreement #340918; granted to M.A. Martínez-González); the Official Spanish Institutions for Funding Scientific Biomedical Research, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn) and Instituto de Salud Carlos III (ISCIII) through the Fondo de Investigación para la Salud (FIS) that is co-funded by the European Regional Development Fund (coordinated FIS projects led by J. Salas-Salvadó and Vidal, including the following projects: PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374, PI14/00972, PI14/00728, PI14/01471, PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183, PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215, PI17/01441, PI17/00508, PI17/01732, PI17/00926, PI19/00957, PI19/00386, PI19/00309, PI19/01032, PI19/00576, PI19/00017, PI19/01226, PI19/00781, PI19/01560, PI19/01332, PI20/01802, PI20/00138, PI20/01532, PI20/00456, PI20/00339, PI20/00557, PI20/00886, PI20/01158), and the Especial Action Project “Implementación y evaluación de una intervención intensiva sobre la actividad física Cohorte PREDIMED-Plus” (J. Salas-Salvadó); the Recercaixa (grant number 2013ACUP00194) (J. Salas-Salvadó). Moreover, J. Salas-Salvadó gratefully acknowledges the financial support by ICREA under the ICREA Academia program; the SEMERGEN grant; International Nut and Dried Fruit Council–FESNAD (long-term effects of an energy-restricted Mediterranean diet on mortality and cardiovascular disease 2014–2015; No. 201302) (M.A. Martínez-González); Department of Health of the Government of Navarra (61/2015), the Fundació La Marató de TV (Ref. 201630.10); grants from the Consejería de Salud de la Junta de Andalucía (PI0458/2013; PS0358/2016; PI0137/2018), the PROMETEO/2017/017 grant from the Generalitat Valenciana, the SEMERGEN grant; grant of support to research groups 35/2011 (Balearic Islands Gov; FEDER funds) (Tur and Bouz). J. K. is supported by the Juan de la Cierva-Incorporación research grant (IJC2019–042420-I) of the Spanish Ministry of Economy, Industry and Competitiveness and European Social Funds. Y. X. is supported by the joint scholarship of King's College London and China Scholarship Council (K-CSC). The authors are especially grateful to all the participants for their collaboration, the staff of the PREDIMED-Plus study for their exceptional contribution, and the personnel of primary care centres for their support.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Royal Society of Chemistry
dc.relation.ispartof Food Funct. 2023 Jan 23;14(2):1011-23
dc.rights This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.
dc.rights.uri http://creativecommons.org/licenses/by-nc/3.0/
dc.title Health associations of liver enzymes and inflammatory scores with urinary citrus flavonoid metabolites
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1039/d2fo02846h
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/340918
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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