Indigenous people from Amazon show genetic signatures of pathogen-driven selection

Couto-Silva, Cainã M.; Nunes, Kelly; Venturini, Gabriela; Castro e Silva, Marcos Araújo; Pereira, Lygia V.; Comas, David, 1969-; Pereira, Alexandre C.; Hünemeier, Tábita

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dc.contributor.author	Couto-Silva, Cainã M.
dc.contributor.author	Nunes, Kelly
dc.contributor.author	Venturini, Gabriela
dc.contributor.author	Castro e Silva, Marcos Araújo
dc.contributor.author	Pereira, Lygia V.
dc.contributor.author	Comas, David, 1969-
dc.contributor.author	Pereira, Alexandre C.
dc.contributor.author	Hünemeier, Tábita
dc.date.accessioned	2023-03-22T07:13:42Z
dc.date.available	2023-03-22T07:13:42Z
dc.date.issued	2023
dc.identifier.citation	Couto-Silva CM, Nunes K, Venturini G, Araújo Castro E Silva M, Pereira LV, Comas D, Pereira A, Hünemeier T. Indigenous people from Amazon show genetic signatures of pathogen-driven selection. Sci Adv. 2023 Mar 10;9(10):eabo0234. DOI: 10.1126/sciadv.abo0234
dc.identifier.issn	2375-2548
dc.identifier.uri	http://hdl.handle.net/10230/56315
dc.description.abstract	Ecological conditions in the Amazon rainforests are historically favorable for the transmission of numerous tropical diseases, especially vector-borne diseases. The high diversity of pathogens likely contributes to the strong selective pressures for human survival and reproduction in this region. However, the genetic basis of human adaptation to this complex ecosystem remains unclear. This study investigates the possible footprints of genetic adaptation to the Amazon rainforest environment by analyzing the genomic data of 19 native populations. The results based on genomic and functional analysis showed an intense signal of natural selection in a set of genes related to Trypanosoma cruzi infection, which is the pathogen responsible for Chagas disease, a neglected tropical parasitic disease native to the Americas that is currently spreading worldwide.
dc.format.mimetype	application/pdf
dc.language.iso	eng
dc.publisher	American Association for the Advancement of Science (AAAS)
dc.relation.ispartof	Sci Adv. 2023 Mar 10;9(10):eabo0234
dc.rights	© 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license, which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.
dc.rights.uri	http://creativecommons.org/licenses/by-nc/4.0/
dc.title	Indigenous people from Amazon show genetic signatures of pathogen-driven selection
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	http://dx.doi.org/10.1126/sciadv.abo0234
dc.rights.accessRights	info:eu-repo/semantics/openAccess
dc.type.version	info:eu-repo/semantics/publishedVersion