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Variation in nicotine metabolization according to biological factors and type of nicotine consumer

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dc.contributor.author Pérez-Martín, Hipólito
dc.contributor.author Lidón-Moyano, Cristina
dc.contributor.author González-Marrón, Adrián
dc.contributor.author Fu, Marcela
dc.contributor.author Pérez Ortuño, Raúl, 1976-
dc.contributor.author Ballbè, Montse
dc.contributor.author Martín-Sánchez, Juan Carlos
dc.contributor.author Pascual Esteban, José A.
dc.contributor.author Fernández, Esteve
dc.contributor.author Martínez-Sánchez, Jose M.
dc.date.accessioned 2023-03-21T07:08:38Z
dc.date.available 2023-03-21T07:08:38Z
dc.date.issued 2023
dc.identifier.citation Pérez-Martín H, Lidón-Moyano C, González-Marrón A, Fu M, Pérez-Ortuño R, Ballbè M, et al. Variation in nicotine metabolization according to biological factors and type of nicotine consumer. Healthcare. 2023 Jan 2;11(2):179. DOI: 10.3390/healthcare11020179
dc.identifier.issn 2227-9032
dc.identifier.uri http://hdl.handle.net/10230/56299
dc.description.abstract This study aims to describe the nicotine metabolite ratio among tobacco smokers and electronic cigarette (e-cigarette) users and nonusers. We analyzed pooled data from a longitudinal and a cross-sectional study of the adult population from the city of Barcelona. The final sample included information on 166 smokers, 164 e-cigarettes users with nicotine, 41 e-cigarette users without nicotine, 95 dual users (users of both products), and 508 nonusers. We used log-linear models to control for the potential confounding effect of the daily number of cigarettes smoked. Salivary nicotine metabolic rate assessment included the rate of nicotine metabolism (cotinine/nicotine) and the nicotine metabolite ratio (trans-3′-hydroxycotinine/cotinine). Exclusive users of e-cigarette without nicotine have the lowest rate of nicotine metabolism (Geometric mean: 0.08, p-values < 0.001) while cigarette smokers have the highest (Geometric mean: 2.08, p-values < 0.001). Nonusers have lower nicotine metabolic rate than cigarette smokers (Geometric means: 0.23 vs. 0.18, p-value < 0.05). Younger individuals (18–44 years) have a higher rate of nicotine metabolism than older individuals (45–64 years and 65–89) (Geometric means: 0.53 vs. 0.42 and 0.31, respectively, p-values < 0.01) and individuals with lower body mass index (21–25 kg/m2) have a higher rate of nicotine metabolism than the rest (26–30 kg/m2 and 31–60 kg/m2) (Geometric means: 0.52 vs. 0.35 and 0.36, respectively-values < 0.01). Nicotine metabolic rates are useful biomarkers when reporting smoking status and biological differences between individuals.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher MDPI
dc.relation.ispartof Healthcare. 2023 Jan 2;11(2):179
dc.rights © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Variation in nicotine metabolization according to biological factors and type of nicotine consumer
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.3390/healthcare11020179
dc.subject.keyword Biomarker
dc.subject.keyword Cotinine
dc.subject.keyword Electronic cigarette
dc.subject.keyword Nicotine
dc.subject.keyword Nicotine metabolism
dc.subject.keyword Smoking
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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