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Epigenetic clock explains white matter hyperintensity burden irrespective of chronological age

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dc.contributor.author Jiménez-Balado, Joan
dc.contributor.author Giralt-Steinhauer, Eva
dc.contributor.author Fernández-Pérez, Isabel
dc.contributor.author Rey, Lucía
dc.contributor.author Cuadrado-Godia, Elisa
dc.contributor.author Ois, Ángel
dc.contributor.author Rodríguez-Campello, Ana
dc.contributor.author Soriano Tarraga, Carolina
dc.contributor.author Lazcano, Uxue
dc.contributor.author Macias-Gómez, Adrià
dc.contributor.author Suárez-Pérez, Antoni
dc.contributor.author Revert, Anna
dc.contributor.author Estragués-Gázquez, Isabel
dc.contributor.author Beltrán Mármol, Marlyn Briggith
dc.contributor.author Medrano-Martorell, Santiago
dc.contributor.author Capellades, Jaume
dc.contributor.author Roquer, Jaume
dc.contributor.author Jiménez Conde, Jordi
dc.date.accessioned 2023-03-21T07:08:35Z
dc.date.available 2023-03-21T07:08:35Z
dc.date.issued 2023
dc.identifier.citation Jiménez-Balado J, Giralt-Steinhauer E, Fernández-Pérez I, Rey L, Cuadrado-Godia E, Ois Á, et al. Epigenetic clock explains white matter hyperintensity burden irrespective of chronological age. Biology. 2023 Jan;12(1):33. DOI: 10.3390/biology12010033
dc.identifier.issn 2079-7737
dc.identifier.uri http://hdl.handle.net/10230/56298
dc.description.abstract In this manuscript we studied the relationship between WMH and biological age (B-age) in patients with acute stroke. We included in this study 247 patients with acute stroke recruited at Hospital del Mar having both epigenetic (DNA methylation) and magnetic resonance imaging data. WMH were measured using a semi-automated method. B-age was calculated using two widely used methods: the Hannum and Horvath formulas. We used multiple linear regression models to interrogate the role of B-age on WMH volume after adjusting for chronological age (C-age) and other covariables. Average C-age of the sample was 68.4 (±11.8) and we observed a relatively high median WMH volume (median = 8.8 cm3, Q1–Q3 = 4.05–18.8). After adjusting for potential confounders, we observed a significant effect of B-ageHannum on WMH volume (βHannum = 0.023, p-value = 0.029) independently of C-age, which remained significant (βC-age = 0.021, p-value = 0.036). Finally, we performed a mediation analysis, which allowed us to discover that 42.7% of the effect of C-age on WMH is mediated by B-ageHannum. On the other hand, B-ageHoarvath showed no significant associations with WMH after being adjusted for C-age. In conclusion, we show for the first time that biological age, measured through DNA methylation, contributes substantially to explain WMH volumetric burden irrespective of chronological age.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher MDPI
dc.relation.ispartof Biology. 2023 Jan;12(1):33
dc.rights © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Epigenetic clock explains white matter hyperintensity burden irrespective of chronological age
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.3390/biology12010033
dc.subject.keyword White matter hyperintensities
dc.subject.keyword Cerebral small vessel disease
dc.subject.keyword Epigenetics
dc.subject.keyword DNA methylation
dc.subject.keyword Biological age
dc.subject.keyword Epigenetic clock
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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