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Plasma metabolite profiles associated with the amount and source of meat and fish consumption and the risk of type 2 diabetes

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dc.contributor.author García-Gavilán, Jesús
dc.contributor.author Fitó Colomer, Montserrat
dc.contributor.author Salas-Salvadó, Jordi
dc.date.accessioned 2023-02-07T13:07:21Z
dc.date.available 2023-02-07T13:07:21Z
dc.date.issued 2022
dc.identifier.citation García-Gavilán J, Nishi SK, Paz-Graniel I, Guasch-Ferré M, Razquin C, Clish CB, et al. Plasma metabolite profiles associated with the amount and source of meat and fish consumption and the risk of type 2 diabetes. Mol Nutr Food Res. 2022 Dec;66(23):e2200145. DOI: 10.1002/mnfr.202200145
dc.identifier.issn 1613-4125
dc.identifier.uri http://hdl.handle.net/10230/55661
dc.description.abstract Scope: Consumption of meat has been associated with a higher risk of type 2 diabetes (T2D), but if plasma metabolite profiles associated with these foods reflect this relationship is unknown. The objective is to identify a metabolite signature of consumption of total meat (TM), red meat (RM), processed red meat (PRM), and fish and examine if they are associated with T2D risk. Methods and results: The discovery population includes 1833 participants from the PREDIMED trial. The internal validation sample includes 1522 participants with available 1-year follow-up metabolomic data. Associations between metabolites and TM, RM, PRM, and fish are evaluated with elastic net regression. Associations between the profiles and incident T2D are estimated using Cox regressions. The profiles included 72 metabolites for TM, 69 for RM, 74 for PRM, and 66 for fish. After adjusting for T2D risk factors, only profiles of TM (Hazard Ratio (HR): 1.25, 95% CI: 1.06-1.49), RM (HR: 1.27, 95% CI: 1.07-1.52), and PRM (HR: 1.27, 95% CI: 1.07-1.51) are associated with T2D. Conclusions: The consumption of TM, its subtypes, and fish is associated with different metabolites, some of which have been previously associated with T2D. Scores based on the identified metabolites for TM, RM, and PRM show a significant association with T2D risk.
dc.description.sponsorship The PREDIMED study was funded by NIH grants R01 HL118264 and R01 DK102896 and by the Spanish Ministry of Health (Instituto de Salud Carlos III, The PREDIMED Network grant RD 06/0045, 2006–2013, coordinated by MAM-G; and a previous network grant RTIC-G03/140, 2003–2005, coordinated R. Estruch). Additional grants were received from the Ministerio de Economía y Competitividad-Fondo Europeo de Desarrollo Regional (Projects CNIC-06/2007, CIBER 06/03, PI06-1326, PI07-0954, PI11/02505, SAF2009-12304, and AGL2010-22319-C03-03) and the Generalitat Valenciana (ACOMP2010-181, AP-111/10, AP-042/11, ACOM2011/145, ACOMP/2012/190, ACOMP/2013/159, ACOMP/213/165, and PROMETEO17/2017). M.G.-F. is supported by R21AG070375-01A1. J.S.-S. gratefully acknowledges the financial support by ICREA under the ICREA Academia program. I.P.-G. receives a grant from the Ministerio de Ciencia, Innovación y Universidades (MICINN) (FPU 17/01925). S.K.N. gratefully acknowledges support from a postdoctoral fellowship from the Canadian Institutes of Health Research (CIHR, MFE-171207).
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Wiley
dc.relation.ispartof Mol Nutr Food Res. 2022 Dec;66(23):e2200145
dc.rights © 2022 The Authors. Molecular Nutrition & Food Research published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.title Plasma metabolite profiles associated with the amount and source of meat and fish consumption and the risk of type 2 diabetes
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1002/mnfr.202200145
dc.subject.keyword PREDIMED
dc.subject.keyword Fish
dc.subject.keyword Meat
dc.subject.keyword Metabolomics
dc.subject.keyword Type 2 diabetes
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SAF2009-12304
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/AGL2010-22319-C03-03
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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