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The amount of preoperative endometrial tissue surface in relation to final endometrial cancer classification

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dc.contributor.author Vrede, Stephanie W.
dc.contributor.author Hulsman, Anneloes M.C.
dc.contributor.author Reijnen, Casper
dc.contributor.author van de Vijver, Koen K.B.T.
dc.contributor.author Colas, Eva
dc.contributor.author Mancebo Moreno, Gemma
dc.contributor.author Moiola, Cristian Pablo
dc.contributor.author Gil-Moreno, Antonio
dc.contributor.author Huvila, Jutta
dc.contributor.author Koskas, Martin
dc.contributor.author Weinberger, Vit
dc.contributor.author Minář, Luboš
dc.contributor.author Jandáková, Eva
dc.contributor.author Santacana, Maria
dc.contributor.author Matias-Guiu, Xavier
dc.contributor.author Amant, Frédéric
dc.contributor.author Snijders, Marc P.L.M.
dc.contributor.author Küsters-Vandevelde, Heidi V.N.
dc.contributor.author ENITEC-Consortium
dc.contributor.author Bulten, Johan Hans
dc.contributor.author Pijnenborg, Johanna M.A.
dc.date.accessioned 2023-01-26T07:31:25Z
dc.date.available 2023-01-26T07:31:25Z
dc.date.issued 2022
dc.identifier.citation Vrede SW, Hulsman AMC, Reijnen C, Van de Vijver K, Colas E, Mancebo G, Moiola CP, Gil-Moreno A, Huvila J, Koskas M, Weinberger V, Minar L, Jandakova E, Santacana M, Matias-Guiu X, Amant F, Snijders MPLM, Küsters-Vandevelde HVN; ENITEC-consortium; Bulten J, Pijnenborg JMA. The amount of preoperative endometrial tissue surface in relation to final endometrial cancer classification. Gynecol Oncol. 2022 Nov;167(2):196-204. DOI: 10.1016/j.ygyno.2022.08.016
dc.identifier.issn 0090-8258
dc.identifier.uri http://hdl.handle.net/10230/55441
dc.description.abstract Objective: To evaluate whether the amount of preoperative endometrial tissue surface is related to the degree of concordance with final low- and high-grade endometrial cancer (EC). In addition, to determine whether discordance is influenced by sampling method and impacts outcome. Methods: A retrospective cohort study within the European Network for Individualized Treatment of Endometrial Cancer (ENITEC). Surface of preoperative endometrial tissue samples was digitally calculated using ImageJ. Tumor samples were classified into low-grade (grade 1-2 endometrioid EC (EEC)) and high-grade (grade 3 EEC + non-endometroid EC). Results: The study cohort included 573 tumor samples. Overall concordance between pre- and postoperative diagnosis was 60.0%, and 88.8% when classified into low- and high-grade EC. Upgrading (preoperative low-grade, postoperative high-grade EC) was found in 7.8% and downgrading (preoperative high-grade, postoperative low-grade EC) in 26.7%. The median endometrial tissue surface was significantly lower in concordant diagnoses when compared to discordant diagnoses, respectively 18.7 mm2 and 23.5 mm2 (P = 0.022). Sampling method did not influence the concordance in tumor classification. Patients with preoperative high-grade and postoperative low-grade showed significant lower DSS compared to patients with concordant low-grade EC (P = 0.039). Conclusion: The amount of preoperative endometrial tissue surface was inversely related to the degree of concordance with final tumor low- and high-grade. Obtaining higher amount of preoperative endometrial tissue surface does not increase the concordance between pre- and postoperative low- and high-grade diagnosis in EC. Awareness of clinically relevant down- and upgrading is crucial to reduce subsequent over- or undertreatment with impact on outcome.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof Gynecol Oncol. 2022 Nov;167(2):196-204
dc.rights © 2022 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title The amount of preoperative endometrial tissue surface in relation to final endometrial cancer classification
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1016/j.ygyno.2022.08.016
dc.subject.keyword Concordant
dc.subject.keyword Diagnosis
dc.subject.keyword Discordant
dc.subject.keyword Endometrial carcinoma
dc.subject.keyword Endometrial sampling
dc.subject.keyword Pathology
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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