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Sleep and breast and prostate cancer risk in the MCC-Spain study

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dc.contributor.author Turner, Michelle C.
dc.contributor.author Gracia-Lavedan, Esther
dc.contributor.author Papantoniou, Kyriaki, 1983-
dc.contributor.author Aragonés, Núria
dc.contributor.author Castaño Vinyals, Gemma
dc.contributor.author Dierssen Sotos, Trinidad
dc.contributor.author Amiano, Pilar
dc.contributor.author Ardanaz Aicua, Eva
dc.contributor.author Marcos-Delgado, Alba
dc.contributor.author Molina-Barceló, Ana
dc.contributor.author Alguacil Ojeda, Juan
dc.contributor.author Benavente, Yolanda
dc.contributor.author Belmonte, Thalia
dc.contributor.author Jiménez-Moleón, José Juan
dc.contributor.author Marcos-Gragera, Rafael
dc.contributor.author Pérez, Beatriz
dc.contributor.author Gómez-Acebo, Inés
dc.contributor.author Pollán, Marina
dc.contributor.author Kogevinas, Manolis
dc.date.accessioned 2023-01-13T06:56:53Z
dc.date.available 2023-01-13T06:56:53Z
dc.date.issued 2022
dc.identifier.citation Turner MC, Gracia-Lavedan E, Papantoniou K, Aragonés N, Castaño-Vinyals G, Dierssen-Sotos T, Amiano P, Ardanaz E, Marcos-Delgado A, Molina-Barceló A, Alguacil J, Benavente Y, Belmonte T, Jiménez-Moleón JJ, Marcos-Gragera R, Pérez B, Gómez-Acebo I, Pollán M, Kogevinas M. Sleep and breast and prostate cancer risk in the MCC-Spain study. Sci Rep. 2022 Dec 16;12(1):21807. DOI: 10.1038/s41598-022-25789-9
dc.identifier.issn 2045-2322
dc.identifier.uri http://hdl.handle.net/10230/55266
dc.description.abstract Breast and prostate cancers have been associated with circadian disruption. Some previous studies examined associations of sleep duration and breast or prostate cancer risk though findings remain inconsistent. This study examines associations of a range of detailed sleep characteristics and breast and prostate cancer risk in a large-scale population-based case-control study, MCC-Spain. A total of 1738 incident breast cancer cases, 1112 prostate cancer cases and frequency matched controls (n = 1910, and 1493 respectively) were recruited. Detailed data on habitual sleep duration, quality, timing, and daytime napping ("siesta") were collected at recruitment. Additional data on sleep habits during both the previous year and at age 40 years were also subsequently captured. Adjusted odds ratios (ORs) and 95% confidence intervals (CI) were estimated. There were no associations of habitual sleep duration (h), timing of sleep, or any or specific sleep problems, and either breast and prostate cancer risk. There was a significant positive association of ever taking habitual siestas at recruitment and breast cancer risk (OR = 1.22, 95% CI 1.06-1.42), which strengthened with increased frequency or duration. There were also significant positive associations observed for both breast and prostate cancer, among those reporting recent sleep problems, but not sleep problems at age 40 years, in a subsequent circadian questionnaire. Adverse associations with siesta and disturbed sleep during the previous year likely reflect symptoms of developing/diagnosed cancer and comorbidities. Overall, there was no clear association between various sleep characteristics and breast or prostate cancer risk observed.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Nature Research
dc.relation.ispartof Sci Rep. 2022 Dec 16;12(1):21807
dc.rights © The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Sleep and breast and prostate cancer risk in the MCC-Spain study
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1038/s41598-022-25789-9
dc.subject.keyword Cancer
dc.subject.keyword Epidemiology
dc.subject.keyword Risk factors
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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