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Modification of high-density lipoprotein functions by diet and other lifestyle changes: a systematic review of randomized controlled trials

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dc.contributor.author Sanllorente Melenchón, Albert
dc.contributor.author Lassale, Camille
dc.contributor.author Soria-Florido, Maria
dc.contributor.author Castañer, Olga
dc.contributor.author Fitó Colomer, Montserrat
dc.contributor.author Hernáez, Álvaro
dc.date.accessioned 2022-09-30T05:51:02Z
dc.date.available 2022-09-30T05:51:02Z
dc.date.issued 2021
dc.identifier.citation Sanllorente A, Lassale C, Soria-Florido MT, Castañer O, Fitó M, Hernáez Á. Modification of high-density lipoprotein functions by diet and other lifestyle changes: a systematic review of randomized controlled trials. J Clin Med. 2021 Dec 15;10(24):5897. DOI: 10.3390/jcm10245897
dc.identifier.issn 2077-0383
dc.identifier.uri http://hdl.handle.net/10230/54227
dc.description.abstract High-density lipoprotein (HDL) functional traits have emerged as relevant elements that may explain HDL antiatherogenic capacity better than HDL cholesterol levels. These properties have been improved in several lifestyle intervention trials. The aim of this systematic review is to summarize the results of such trials of the most commonly used dietary modifications (fatty acids, cholesterol, antioxidants, alcohol, and calorie restriction) and physical activity. Articles were screened from the Medline database until March 2021, and 118 randomized controlled trials were selected. Results from HDL functions and associated functional components were extracted, including cholesterol efflux capacity, cholesteryl ester transfer protein, lecithin-cholesterol acyltransferase, HDL antioxidant capacity, HDL oxidation status, paraoxonase-1 activity, HDL anti-inflammatory and endothelial protection capacity, HDL-associated phospholipase A2, HDL-associated serum amyloid A, and HDL-alpha-1-antitrypsin. In mainly short-term clinical trials, the consumption of monounsaturated and polyunsaturated fatty acids (particularly omega-3 in fish), and dietary antioxidants showed benefits to HDL functionality, especially in subjects with cardiovascular risk factors. In this regard, antioxidant-rich dietary patterns were able to improve HDL function in both healthy individuals and subjects at high cardiovascular risk. In addition, in randomized trial assays performed mainly in healthy individuals, reverse cholesterol transport with ethanol in moderate quantities enhanced HDL function. Nevertheless, the evidence summarized was of unclear quality and short-term nature and presented heterogeneity in lifestyle modifications, trial designs, and biochemical techniques for the assessment of HDL functions. Such findings should therefore be interpreted with caution. Large-scale, long-term, randomized, controlled trials in different populations and individuals with diverse pathologies are warranted.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher MDPI
dc.relation.ispartof J Clin Med. 2021 Dec 15;10(24):5897
dc.rights © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
dc.rights.uri https://creativecommons.org/licenses/by/4.0/
dc.title Modification of high-density lipoprotein functions by diet and other lifestyle changes: a systematic review of randomized controlled trials
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.3390/jcm10245897
dc.subject.keyword Antioxidants
dc.subject.keyword Ethanol
dc.subject.keyword Fatty acids
dc.subject.keyword High-density lipoprotein
dc.subject.keyword Physical activity
dc.subject.keyword Trials
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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