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Changes in melatonin and sex steroid hormone production among men as a result of rotating night shift work - the HORMONIT study

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dc.contributor.author Harding, Barbara N.
dc.contributor.author Castaño Vinyals, Gemma
dc.contributor.author Palomar Cros, Anna
dc.contributor.author Papantoniou, Kyriaki, 1983-
dc.contributor.author Espinosa Díaz, Ana
dc.contributor.author Skene, Debra J.
dc.contributor.author Middleton, Benita
dc.contributor.author Gómez-Gómez, Àlex
dc.contributor.author Navarrete, José María
dc.contributor.author Such, Patricia
dc.contributor.author Torrejón, Antonio
dc.contributor.author Kogevinas, Manolis
dc.contributor.author Pozo Mendoza, Óscar J., 1975-
dc.date.accessioned 2022-09-27T07:59:39Z
dc.date.available 2022-09-27T07:59:39Z
dc.date.issued 2022
dc.identifier.citation Espinosa A, Skene DJ, et al. Changes in melatonin and sex steroid hormone production among men as a result of rotating night shift work - the HORMONIT study. Scand J Work Environ Health. 2022 Jan 1; 48(1): 41-51. DOI: 10.5271/sjweh.3991
dc.identifier.issn 0355-3140
dc.identifier.uri http://hdl.handle.net/10230/54179
dc.description.abstract Objective: data from real world settings on circadian disruption and subsequent hormone-related changes may explain the higher risk of hormone-dependent cancers among night shift workers.The present study examines the melatonin and sex steroid hormone levels among night shift workers. Methods: we included 44 male, rotating shift workers from a car factory in Spain, sampled both at the end of a 3-week night shift (22:00-06:00 hrs) and a 3-week early morning shift (06:00-14:00 hrs). Participants collected all urine voids over 24-hours during each shift. Urinary concentrations of sex steroid hormones (estrogens, androgens and progestogens) and 6-sulfatoxymelatonin (aMT6s, major melatonin metabolite) were determined. Individual cosinor analysis was used to derive the acrophase (peak time) and area under the curve (total production). Linear mixed models examined intraindividual associations between night shift work and log-transformed 24-hour peak time and total production of hormones compared to early morning shift work. Results: the acrophase was delayed during the night shift for aMT6s [geometric mean difference (GMD) 7.53 hrs, 95% confidence interval (CI) 4.46-10.60], androgens (eg, testosterone: GMD 6.83 hrs, 95% CI 0.34-13.32) and progestogens (eg, 17-hydroxyprogesterone: GMD 4.54 hrs, 95% CI 2.92-6.16) compared to the early morning shift. We found a higher production of adrenal androgen 11-oxoandrosterone/11-oxoetiocholanolone [geometric mean ratio (GMR) 1.43, 95% CI 1.12-1.81], and a lower production of adrenal progestogen 16-cysteinylprogesterone (GMR 0.79, 95% CI 0.67-0.93) during the night shift compared to the early morning shift levels. Conclusions: night shift work was associated with melatonin and sex hormone-related changes in timing and total production, providing insight into the mechanistic path for its association with hormone-dependent cancer.
dc.description.sponsorship The study was partially funded by the Instituto de Salud Carlos III-FEDER (PI14/00444). The Spanish Health National system is acknowledged for the support of OP (CPII16/00027). ISGlobal acknowledges support from the Spanish Ministry of Science and Innovation through the “Centro de Excelencia Severo Ochoa 2019-2023” Program (CEX2018-000806-S), and support from the Generalitat de Catalunya through the CERCA Program.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Nordic Association of Occupational Safety and Health
dc.rights Copyright : © Scandinavian Journal of Work, Environment & Health. This work is licensed under a Creative Commons Attribution 4.0 International License. http://creativecommons.org/licenses/by/4.0/
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.subject.other Melatonina
dc.subject.other Hormones esteroides
dc.subject.other Treballadors
dc.subject.other Càncer
dc.subject.other Càncer--Aspectes ambientals
dc.title Changes in melatonin and sex steroid hormone production among men as a result of rotating night shift work - the HORMONIT study
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.5271/sjweh.3991
dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/CEX2018-000806-S
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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