Welcome to the UPF Digital Repository

Arterial stiffness in type 1 diabetes: the case for the arterial wall itself as a target organ

Show simple item record

dc.contributor.author González Clemente, José Miguel
dc.contributor.author Cano, Albert
dc.contributor.author Albert, Lara
dc.contributor.author Giménez Palop, Olga
dc.contributor.author Romero, Ana
dc.contributor.author Berlanga, Eugenio
dc.contributor.author Vendrell, Joan
dc.contributor.author Llauradó Cabot, Gemma
dc.date.accessioned 2022-06-17T06:36:32Z
dc.date.available 2022-06-17T06:36:32Z
dc.date.issued 2021
dc.identifier.citation González-Clemente JM, Cano A, Albert L, Giménez-Palop O, Romero A, Berlanga E, et al. Arterial stiffness in type 1 diabetes: the case for the arterial wall itself as a target òrgan. J Clin Med. 2021 Aug 16; 10(16): 3616. DOI: 10.3390/jcm10163616
dc.identifier.issn 2077-0383
dc.identifier.uri http://hdl.handle.net/10230/53518
dc.description.abstract Arterial stiffness (AS) integrates the cumulative burden of known and unknown cardiovascular risk factors on the elastic wall of large arteries along the lifespan of an individual. As a marker of vascular aging, AS is an independent predictor of cardiovascular events and improves cardiovascular risk prediction when added to the Framingham Risk Score. In addition, AS may affect the microvasculature and promote the development of microvascular complications. Its impact on both the macro- and microvasculature has led to the concept that the arterial wall itself should be considered as a target organ. Here, we review the biological and clinical consequences of AS on the macro- and microvasculature and the measurement of AS in routine clinical practice. We also discuss the pathophysiological mechanisms underpinning AS development using diabetes and, in particular, type 1 diabetes, as a disease model with a high risk of cardiovascular events and microvascular complications that are accelerated by AS.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher MDPI
dc.rights Copyright © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Arterial stiffness in type 1 diabetes: the case for the arterial wall itself as a target organ
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.3390/jcm10163616
dc.subject.keyword Arterial stiffness
dc.subject.keyword Cardiovascular risk
dc.subject.keyword Double diabetes
dc.subject.keyword Insulin resistance
dc.subject.keyword Lipoprotein particles
dc.subject.keyword Microvascular complications
dc.subject.keyword Pulse wave velocity
dc.subject.keyword Type 1 diabetes
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


This item appears in the following Collection(s)

Show simple item record

Search DSpace

Advanced Search


My Account


Compliant to Partaking