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The use of lower or higher than recommended doses of folic acid supplements during pregnancy is associated with child attentional dysfunction at 4-5 years of age in the INMA Project

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dc.contributor.author Compañ Gabucio, Laura María
dc.contributor.author García de la Hera, Manuela
dc.contributor.author Torres Collado, Laura
dc.contributor.author Fernández-Somoano, Ana
dc.contributor.author Tardón, Adonina
dc.contributor.author Guxens Junyent, Mònica
dc.contributor.author Vrijheid, Martine
dc.contributor.author Rebagliato, Marisa
dc.contributor.author Murcia, Mario
dc.contributor.author Ibarluzea, Jesús
dc.contributor.author Martí, Itxaso
dc.contributor.author Vioque, Jesus
dc.date.accessioned 2022-05-30T06:34:26Z
dc.date.available 2022-05-30T06:34:26Z
dc.date.issued 2021
dc.identifier.citation Compañ Gabucio LM, García de la Hera M, Torres Collado L, Fernández-Somoano A, Tardón A, Guxens M, Vrijheid M, Rebagliato M, Murcia M, Ibarluzea J, Martí I, Vioque J. The use of lower or higher than recommended doses of folic acid supplements during pregnancy is associated with child attentional dysfunction at 4-5 years of age in the INMA Project. Nutrients. 2021 Jan 23;13(2):327. DOI: 10.3390/nu13020327
dc.identifier.issn 2072-6643
dc.identifier.uri http://hdl.handle.net/10230/53300
dc.description.abstract We assessed the association between the use of lower- and higher-than-recommended doses of folic acid supplements (FAs) during pregnancy and attentional function in boys and girls at age of 4-5. We analyzed data from 1329 mother-child pairs from the mother-child cohort INfancia y Medio Ambiente Project (INMA) study. Information on FAs use during pregnancy was collected in personal interviews at weeks 12 and 30, and categorized in <400, 400-999 (recommended dose), and ≥1000 μg/day. Child attentional function was assessed by Conners' Kiddie Continuous Performance Test. Multivariable regression analyses were used to estimate incidence rate ratios (IRR) and beta coefficients with 95% confidence intervals (CI). Compared to recommended FAs doses, the periconceptional use of <400 and ≥1000 μg/day was associated with higher risk of omission errors-IRR = 1.14 (95% CI: 1.01; 1.29) and IRR = 1.16 (95% CI: 1.02; 1.33), respectively. The use of FAs < 400 μg/day and ≥1000 μg/day was significantly associated with deficits of attentional function only in boys. FAs use < 400 μg/day was associated with higher omission errors with IRR = 1.22 and increased hit reaction time (HRT) β = 34.36, and FAs use ≥ 1000 μg/day was associated with increased HRT β = 33.18 and HRT standard error β = 3.31. The periconceptional use of FAs below or above the recommended doses is associated with deficits of attentional function in children at age of 4-5, particularly in boys.
dc.description.sponsorship This research was funded by grants from UE (FP7-ENV-2011 cod 282957 and HEALTH.2010.2.4.5-1); Spanish Institute of Health Carlos III-Ministry of Economy and Competitiveness (Red INMA G03/176, CB06/02/0041; FIS-FEDER: PI03/1615, PI04/1509, PI04/1112, PI04/1931, PI05/1079, PI05/1052, PI06/1213, PI06/0867, PI07/0314, PI09/02647, PI11/01007, PI11/02591, PI11/02038, PI12/00610, PI13/1944, PI13/2032, PI14/00891, PI14/01687, PI16/1288, PI17/00663, PI041436, PI081151, PI042018, PI09/02311, PI13/02429, PI18/00909, PI18/01142, PI09/00090, incl. FEDER funds; Miguel Servet-FEDER CP11/00178, CP15/00025, CPII16/00051 and CPII18/00018); Spanish Ministry of Science and Innovation and the State Research Agency (“Centro de Excelencia Severo Ochoa 2019-2023” Program CEX2018-000806-S); Generalitat Valenciana (FISABIO UGP 15-230, UGP-15-244, and UGP-15-249); Generalitat de Catalunya-CIRIT (1999SGR 00241 and support through the CERCA Program), ISGlobal is a member of the CERCA Program; Fundació La marató de TV3 (090430); CIBERESP; Obra Social Cajastur/Fundación Liberbank; Universidad de Oviedo; Alicia Koplowitz Foundation 2017; Department of Health of the Basque Government (2005111093); Department of Health of the Basque Government (2013111089); Provincial Government of Gipuzkoa (DFG06/002); annual agreements with the municipalities of the study area (Zumarraga, Urretxu, Legazpi, Azkoitia y Azpeitia y Beasain).
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher MDPI
dc.relation.ispartof Nutrients. 2021 Jan 23;13(2):327
dc.rights © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title The use of lower or higher than recommended doses of folic acid supplements during pregnancy is associated with child attentional dysfunction at 4-5 years of age in the INMA Project
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.3390/nu13020327
dc.subject.keyword Attentional function
dc.subject.keyword Children
dc.subject.keyword Folic acid
dc.subject.keyword Neurodevelopment
dc.subject.keyword Pregnancy
dc.subject.keyword Supplement use
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/282957
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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