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Lifestyle and behavioral factors and mitochondrial DNA copy number in a diverse cohort of mid-life and older adults

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dc.contributor.author Vyas, Chirag M.
dc.contributor.author Ogata, Soshiro
dc.contributor.author Reynolds, Charles F. 3rd
dc.contributor.author Mischoulon, David
dc.contributor.author Chang, Grace
dc.contributor.author Cook, Nancy R.
dc.contributor.author Manson, JoAnn E.
dc.contributor.author Crous-Bou, Marta
dc.contributor.author De Vivo, Immaculata
dc.contributor.author Okereke, Olivia I.
dc.date.accessioned 2022-01-28T08:01:13Z
dc.date.available 2022-01-28T08:01:13Z
dc.date.issued 2020
dc.identifier.citation Vyas CM, Ogata S, Reynolds CF 3rd, Mischoulon D, Chang G, Cook NR, et al. Lifestyle and behavioral factors and mitochondrial DNA copy number in a diverse cohort of mid-life and older adults. PLoS One. 2020 Aug 12; 15(8): e0237235. DOI: 10.1371/journal.pone.0237235
dc.identifier.issn 1932-6203
dc.identifier.uri http://hdl.handle.net/10230/52350
dc.description.abstract Mitochondrial DNA copy number (mtDNAcn) is a putative biomarker of oxidative stress and biological aging. Modifiable factors, including physical activity (PA), avoidance of heavy alcohol use and smoking, and maintaining good mental health, may reduce oxidative stress and promote healthy aging. Yet, limited data exist regarding how these factors are associated with mtDNAcn or whether age, sex or race/ethnicity moderate associations. In this cross-sectional study, we selected 391 adults (183 non-Hispanic White, 110 Black and 98 Hispanic; mean = 67 years) from the VITAL-DEP (VITamin D and OmegA-3 TriaL-Depression Endpoint Prevention) ancillary to the VITAL trial. We estimated associations between lifestyle and behavioral factors (PA, alcohol consumption, cigarette smoking and depression) and log-transformed mtDNAcn using multivariable linear regression models. MtDNAcn was not correlated with chronological age; women had ~17% higher mtDNAcn compared to men. There were no significant associations between PA measures (frequency, amount or intensity) or alcohol consumption with mtDNAcn. Cigarette smoking (per 5 pack-years) was significantly associated with mtDNAcn (percent difference = -2.9% (95% confidence interval (CI) = -5.4%, -0.4%)); a large contrast was observed among heavy vs. non-smokers (≥30 vs. 0 pack-years): percent difference = -28.5% (95% CI = -44.2%, -8.3%). The estimate of mtDNAcn was suggestively different for past vs. no depression history (percent difference = -15.1% 95% CI = -30.8%, 4.1%), but this difference was not statistically significant. The association between smoking and log-mtDNAcn varied by sex and race/ethnicity; it was stronger in men and Black participants. While chance findings cannot be excluded, results from this study support associations of smoking, but not chronological age, with mtDNAcn and suggest nuanced considerations of mtDNAcn as indicative of varying oxidative stress states vs. biological aging itself.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Public Library of Science (PLoS)
dc.rights Copyright © 2020 Vyas et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, http://creativecommons.org/licenses/by/4.0/ which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.subject.other ADN mitocondrial
dc.subject.other Marcadors bioquímics
dc.subject.other Persones grans
dc.subject.other Estils de vida
dc.title Lifestyle and behavioral factors and mitochondrial DNA copy number in a diverse cohort of mid-life and older adults
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1371/journal.pone.0237235
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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