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Cocaine-seeking behaviour is differentially expressed in male and female mice exposed to maternal separation and is associated with alterations in AMPA receptors subunits in the medial prefrontal cortex

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dc.contributor.author Castro Zavala, Adriana, 1988-
dc.contributor.author Martín Sánchez, Ana
dc.contributor.author Montalvo-Martínez, Larisa
dc.contributor.author Camacho-Morales, Alberto
dc.contributor.author Valverde Granados, Olga
dc.date.accessioned 2021-11-17T07:38:40Z
dc.date.issued 2021
dc.identifier.citation Castro-Zavala A, Martín-Sánchez A, Montalvo-Martínez L, Camacho-Morales A, Valverde O. Cocaine-seeking behaviour is differentially expressed in male and female mice exposed to maternal separation and is associated with alterations in AMPA receptors subunits in the medial prefrontal cortex. Prog Neuropsychopharmacol Biol Psychiatry. 2021; 109:110262. DOI: 10.1016/j.pnpbp.2021.110262
dc.identifier.issn 0278-5846
dc.identifier.uri http://hdl.handle.net/10230/48999
dc.description.abstract According with clinical data, women evolve differently from drug use to drug abuse. Among drugs of abuse, cocaine is the most consumed psychostimulant. Animal studies demonstrated that females show increased motivation to seek cocaine during the self-administration paradigm (SA) than males. Moreover, suffering childhood adversity or major depressive disorder are two factors that could increase the predisposition to suffer cocaine addiction. Maternal separation with early weaning (MSEW) is an animal model that allows examining the impact of early-life stress on cocaine abuse. In this study, we aimed to explore changes in MSEW-induced cocaine-seeking motivation to determine potential associations between despair-like behaviour and cocaine-seeking. We also evaluated possible alterations in the AMPA receptors (AMPArs) composition in the medial prefrontal cortex (mPFC) of these mice. We exposed mice to MSEW and the behavioural tests were performed during adulthood. Moreover, GluA1, GluA2 mRNA and protein expression were evaluated in the mPFC. Results show higher cocaine-seeking in standard nest females, as well as an increase in GluA1 and GluA2 protein expression. Moreover, MSEW induces downregulation of Gria2 and increases the Gria1/Gria2 ratio, only in male mice. In conclusion, female mice show different composition of the AMPA receptor in the mPFC and MSEW alters the glutamatergic system in the mPFC of male mice.
dc.description.sponsorship This study was supported by the Ministerio de Economia y Competitividad (grant number SAF2016-75966-R-FEDER; PID2019-104077-RB-100), Ministerio de Sanidad (Retic-ISCIII, RD16/017/010 and Plan Nacional sobre Drogas 2018/007) to O·V., and the Consejo Nacional de Ciencia y Tecnología in Mexico (CONACYT) (CB-2015-255317 to A.C.-M., 582196 for L.M.-M. and 276577 for A.C-Z). The Department of Experimental and Health Sciences (UPF) is an “Unidad de Excelencia María de Maeztu” funded by the MINECO (Ref. CEXS-2018-000792).
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof Prog Neuropsychopharmacol Biol Psychiatry. 2021; 109:110262
dc.rights © 2021 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license(http://creativecommons.org/licenses/by-nc-nd/4.0/).
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.title Cocaine-seeking behaviour is differentially expressed in male and female mice exposed to maternal separation and is associated with alterations in AMPA receptors subunits in the medial prefrontal cortex
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1016/j.pnpbp.2021.110262
dc.subject.keyword Cocaine self-administration
dc.subject.keyword Despair-like behaviour
dc.subject.keyword GluA1
dc.subject.keyword GluA2
dc.subject.keyword Gria1
dc.subject.keyword Gria2
dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/SAF2016-75966-R
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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