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Parametric imaging of dual-time window [18 F]flutemetamol and [18 F]florbetaben studies

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dc.contributor.author Heeman, Fiona
dc.contributor.author Yaqub, Maqsood
dc.contributor.author Hendriks, Janine
dc.contributor.author Bader, Ilona
dc.contributor.author Barkhof, Frederik
dc.contributor.author Gispert López, Juan Domingo
dc.contributor.author van Berckel, Bart N. M.
dc.contributor.author Lopes Alves, Isadora
dc.contributor.author Lammertsma, Adriaan A.
dc.date.accessioned 2021-10-27T06:56:59Z
dc.date.available 2021-10-27T06:56:59Z
dc.date.issued 2021
dc.identifier.citation Heeman F, Yaqub M, Hendriks J, Bader I, Barkhof F, Gispert JD, van Berckel BNM, Lopes Alves I, Lammertsma AA. Parametric imaging of dual-time window [18 F]flutemetamol and [18 F]florbetaben studies. Neuroimage. 2021;234:117953. DOI: 10.1016/j.neuroimage.2021.117953
dc.identifier.issn 1053-8119
dc.identifier.uri http://hdl.handle.net/10230/48827
dc.description.abstract Optimal pharmacokinetic models for quantifying amyloid beta (Aβ) burden using both [18F]flutemetamol and [18F]florbetaben scans have previously been identified at a region of interest (ROI) level. The purpose of this study was to determine optimal quantitative methods for parametric analyses of [18F]flutemetamol and [18F]florbetaben scans. Forty-six participants were scanned on a PET/MR scanner using a dual-time window protocol and either [18F]flutemetamol (N=24) or [18F]florbetaben (N=22). The following parametric approaches were used to derive DVR estimates: reference Logan (RLogan), receptor parametric mapping (RPM), two-step simplified reference tissue model (SRTM2) and multilinear reference tissue models (MRTM0, MRTM1, MRTM2), all with cerebellar grey matter as reference tissue. In addition, a standardized uptake value ratio (SUVR) was calculated for the 90-110 min post injection interval. All parametric images were assessed visually. Regional outcome measures were compared with those from a validated ROI method, i.e. DVR derived using RLogan. Visually, RPM, and SRTM2 performed best across tracers and, in addition to SUVR, provided highest AUC values for differentiating between Aβ-positive vs Aβ-negative scans ([18F]flutemetamol: range AUC=0.96-0.97 [18F]florbetaben: range AUC=0.83-0.85). Outcome parameters of most methods were highly correlated with the reference method (R2≥0.87), while lowest correlation were observed for MRTM2 (R2=0.71-0.80). Furthermore, bias was low (≤5%) and independent of underlying amyloid burden for MRTM0 and MRTM1. The optimal parametric method differed per evaluated aspect; however, the best compromise across aspects was found for MRTM0 followed by SRTM2, for both tracers. SRTM2 is the preferred method for parametric imaging because, in addition to its good performance, it has the advantage of providing a measure of relative perfusion (R1), which is useful for measuring disease progression.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof Neuroimage. 2021;234:117953
dc.rights © 2021 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Parametric imaging of dual-time window [18 F]flutemetamol and [18 F]florbetaben studies
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1016/j.neuroimage.2021.117953
dc.subject.keyword Amyloid PET
dc.subject.keyword PET quantification
dc.subject.keyword Parametric imaging
dc.subject.keyword [(18)F]florbetaben
dc.subject.keyword [(18)F]flutemetamol
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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