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dc.contributor.author | Olmos Alpiste, Ferran |
dc.contributor.author | Segura Tigell, Sonia |
dc.contributor.author | Tomás-Velázquez, Alejandra |
dc.contributor.author | Aguado, Leyre |
dc.contributor.author | España, Agustín |
dc.contributor.author | Arriola Aperribay, Edurne |
dc.contributor.author | Martín-Algarra, Salvador |
dc.contributor.author | Barranco Sanz, Luis Carlos |
dc.contributor.author | Lloreta Trull, Josep, 1958- |
dc.contributor.author | Pujol Vallverdú, Ramon Maria |
dc.date.accessioned | 2021-10-22T07:31:17Z |
dc.date.issued | 2021 |
dc.identifier.citation | Olmos-Alpiste F, Segura S, Tomás-Velázquez A, Aguado L, España A, Arriola E, Martín-Algarra S, Barranco C, Lloreta J, Pujol RM. Diffuse dermal mucinosis secondary to colony-stimulating factor 1 receptor monoclonal antibody treatment: A novel and peculiar drug-induced diffuse cutaneous mucinosis. J Dermatol. 2021; 48(3):380-4. DOI: 10.1111/1346-8138.15662 |
dc.identifier.issn | 0385-2407 |
dc.identifier.uri | http://hdl.handle.net/10230/48759 |
dc.description.abstract | Colony-stimulating factor 1 receptor (CSF1R) inhibitors represent a new class of immune-modulatory drugs, mostly investigated in clinical trials in different malignant neoplasms. Four patients, diagnosed with recurrent or advanced malignant neoplasm and treated with a combination of anti-programmed death ligand 1 and anti-CSF1R monoclonal antibodies, developed an asymptomatic cutaneous eruption characterized by an ill-defined pseudoedematous to waxy diffuse infiltration with a reticular cobblestone-like pattern. Histopathological examination revealed diffuse mucin deposition involving the superficial and mid-dermis with fragmented and scattered elastic fibers. The exact pathogenic mechanisms implicated in the development of mucin deposits in patients treated with CSF1R inhibitors remain to be elucidated. A reduced degradation and clearance of components of the extracellular matrix by macrophages secondary to CSF1 pathway inhibition may be hypothesized. Shredding and fragmentation of elastic fibers may be a result of the increased accumulation of mucopolysaccharides. This observation illustrates the new spectrum of skin-related toxicities secondary to new targeting therapies. This may contribute to a better understanding of the underlying pathogenic mechanisms in skin diseases characterized by a persistent dermal glycosaminoglycan deposition. |
dc.format.mimetype | application/pdf |
dc.language.iso | eng |
dc.publisher | Wiley |
dc.rights | This is the peer reviewed version of the following article: Olmos-Alpiste F, Segura S, Tomás-Velázquez A, Aguado L, España A, Arriola E, Martín-Algarra S, Barranco C, Lloreta J, Pujol RM. Diffuse dermal mucinosis secondary to colony-stimulating factor 1 receptor monoclonal antibody treatment: A novel and peculiar drug-induced diffuse cutaneous mucinosis. J Dermatol. 2021; 48(3):380-4. DOI: 10.1111/1346-8138.15662, which has been published in final form at http://dx.doi.org/10.1111/1346-8138.15662. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. |
dc.title | Diffuse dermal mucinosis secondary to colony-stimulating factor 1 receptor monoclonal antibody treatment: A novel and peculiar drug-induced diffuse cutaneous mucinosis |
dc.type | info:eu-repo/semantics/article |
dc.identifier.doi | http://dx.doi.org/10.1111/1346-8138.15662 |
dc.subject.keyword | Anti-programmed death ligand 1 |
dc.subject.keyword | Colony-stimulating factor 1 receptor inhibitor |
dc.subject.keyword | Dermal mucinosis |
dc.subject.keyword | Drug reaction |
dc.subject.keyword | Skin toxicity |
dc.rights.accessRights | info:eu-repo/semantics/openAccess |
dc.type.version | info:eu-repo/semantics/acceptedVersion |