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Prolonged QT interval in SARS-CoV-2 infection: prevalence and prognosis

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dc.contributor.author Farré López, Núria
dc.contributor.author Mojón Álvarez, Diana
dc.contributor.author Llagostera Martín, Marc
dc.contributor.author Belarte Tornero, Laia Carla
dc.contributor.author Calvo-Fernández, Alicia
dc.contributor.author Vallés Gras, Ermengol
dc.contributor.author Negrete, Alejandro
dc.contributor.author Garcia Guimaraes, Marcos
dc.contributor.author Bartolomé Fernández, Yolanda
dc.contributor.author Fernández García, Camino
dc.contributor.author García-Duran, Ana Beatriz
dc.contributor.author Marrugat de la Iglesia, Jaume
dc.contributor.author Vaquerizo Montilla, Beatriz
dc.date.accessioned 2021-10-19T07:08:09Z
dc.date.available 2021-10-19T07:08:09Z
dc.date.issued 2020
dc.identifier.citation Farré N, Mojón D, Llagostera M, Belarte-Tornero LC, Calvo-Fernández A, Vallés E, et al. Prolonged QT interval in SARS-CoV-2 infection: prevalence and prognosis. J Clin Med. 2020 Aug 21; 9(9): 2712. DOI: 10.3390/jcm9092712
dc.identifier.issn 2077-0383
dc.identifier.uri http://hdl.handle.net/10230/48695
dc.description.abstract Background: The prognostic value of a prolonged QT interval in SARS-Cov2 infection is not well known. Objective: To determine whether the presence of a prolonged QT on admission is an independent factor for mortality in SARS-Cov2 hospitalized patients. Methods: Single-center cohort of 623 consecutive patients with positive polymerase-chain-reaction test (PCR) to SARS Cov2, recruited from 27 February to 7 April 2020. An electrocardiogram was taken on these patients within the first 48 h after diagnosis and before the administration of any medication with a known effect on QT interval. A prolonged QT interval was defined as a corrected QT (QTc) interval >480 milliseconds. Patients were followed up with until 10 May 2020. Results: Sixty-one patients (9.8%) had prolonged QTc and only 3.2% had a baseline QTc > 500 milliseconds. Patients with prolonged QTc were older, had more comorbidities, and higher levels of immune-inflammatory markers. There were no episodes of ventricular tachycardia or ventricular fibrillation during hospitalization. All-cause death was higher in patients with prolonged QTc (41.0% vs. 8.7%, p < 0.001, multivariable HR 2.68 (1.58-4.55), p < 0.001). Conclusions: Almost 10% of patients with COVID-19 infection have a prolonged QTc interval on admission. A prolonged QTc was independently associated with a higher mortality even after adjustment for age, comorbidities, and treatment with hydroxychloroquine and azithromycin. An electrocardiogram should be included on admission to identify high-risk SARS-CoV-2 patients.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher MDPI
dc.rights Copyright © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Prolonged QT interval in SARS-CoV-2 infection: prevalence and prognosis
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.3390/jcm9092712
dc.subject.keyword COVID-19
dc.subject.keyword QT interval
dc.subject.keyword Azithromycin
dc.subject.keyword Death
dc.subject.keyword Hydroxychloroquine
dc.subject.keyword Prognosis
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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