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Interplay between notch and YAP/TAZ pathways in the regulation of cell fate during embryo development

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dc.contributor.author Engel-Pizcueta, Carolyn
dc.contributor.author Pujades Corbi, Cristina
dc.date.accessioned 2021-10-19T06:09:59Z
dc.date.available 2021-10-19T06:09:59Z
dc.date.issued 2021
dc.identifier.citation Engel-Pizcueta C, Pujades C. Interplay between notch and YAP/TAZ pathways in the regulation of cell fate during embryo development. Front Cell Dev Biol. 2021;9:711531. DOI: 10.3389/fcell.2021.711531
dc.identifier.issn 2296-634X
dc.identifier.uri http://hdl.handle.net/10230/48694
dc.description.abstract Cells in growing tissues receive both biochemical and physical cues from their microenvironment. Growing evidence has shown that mechanical signals are fundamental regulators of cell behavior. However, how physical properties of the microenvironment are transduced into critical cell behaviors, such as proliferation, progenitor maintenance, or differentiation during development, is still poorly understood. The transcriptional co-activators YAP/TAZ shuttle between the cytoplasm and the nucleus in response to multiple inputs and have emerged as important regulators of tissue growth and regeneration. YAP/TAZ sense and transduce physical cues, such as those from the extracellular matrix or the actomyosin cytoskeleton, to regulate gene expression, thus allowing them to function as gatekeepers of progenitor behavior in several developmental contexts. The Notch pathway is a key signaling pathway that controls binary cell fate decisions through cell-cell communication in a context-dependent manner. Recent reports now suggest that the crosstalk between these two pathways is critical for maintaining the balance between progenitor maintenance and cell differentiation in different tissues. How this crosstalk integrates with morphogenesis and changes in tissue architecture during development is still an open question. Here, we discuss how progenitor cell proliferation, specification, and differentiation are coordinated with morphogenesis to construct a functional organ. We will pay special attention to the interplay between YAP/TAZ and Notch signaling pathways in determining cell fate decisions and discuss whether this represents a general mechanism of regulating cell fate during development. We will focus on research carried out in vertebrate embryos that demonstrate the important roles of mechanical cues in stem cell biology and discuss future challenges.
dc.description.sponsorship This work was funded by the Agencia Española de Investigación AEI-PGC2018-095663-B-I00 and RED2018-102553-T grants (MICIU-FEDER) to CP. DCEXS-UPF is a Unidad de Excelencia María de Maeztu funded by the AEI (CEX2018-000792-M). CE-P is a recipient of a predoctoral FPU fellowship from the Spanish Ministry of Universities (FPU17/06034). CP is a recipient of ICREA Academia award (Generalitat de Catalunya).
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Frontiers
dc.relation.ispartof Front Cell Dev Biol. 2021;9:711531
dc.rights © 2021 Engel-Pizcueta and Pujades. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Interplay between notch and YAP/TAZ pathways in the regulation of cell fate during embryo development
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.3389/fcell.2021.711531
dc.subject.keyword Notch signaling pathway
dc.subject.keyword YAP/TAZ pathway
dc.subject.keyword Cell fate
dc.subject.keyword Embryonic development
dc.subject.keyword Mechanical cues
dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PGC2018-095663-B-I00
dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/RED2018-102553-T
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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