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Enhancers with tissue-specific activity are enriched in intronic regions

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dc.contributor.author Borsari, Beatrice, 1992-
dc.contributor.author Villegas Mirón, Pablo
dc.contributor.author Pérez-Lluch, Sílvia
dc.contributor.author Turpin, Isabel
dc.contributor.author Laayouni, Hafid, 1968-
dc.contributor.author Segarra Casas, Alba
dc.contributor.author Bertranpetit, Jaume, 1952-
dc.contributor.author Guigó Serra, Roderic
dc.contributor.author Acosta, Sandra
dc.date.accessioned 2021-09-10T07:18:59Z
dc.date.issued 2021
dc.identifier.citation Borsari B, Villegas-Mirón P, Pérez-Lluch S, Turpin I, Laayouni H, Segarra-Casas A, Bertranpetit J, Guigó R, Acosta S. Enhancers with tissue-specific activity are enriched in intronic regions. Genome Res. 2021;31(8):1325-36. DOI: 10.1101/gr.270371.120
dc.identifier.issn 1088-9051
dc.identifier.uri http://hdl.handle.net/10230/48421
dc.description.abstract Tissue function and homeostasis reflect the gene expression signature by which the combination of ubiquitous and tissue-specific genes contribute to the tissue maintenance and stimuli-responsive function. Enhancers are central to control this tissue-specific gene expression pattern. Here, we explore the correlation between the genomic location of enhancers and their role in tissue-specific gene expression. We find that enhancers showing tissue-specific activity are highly enriched in intronic regions and regulate the expression of genes involved in tissue-specific functions, whereas housekeeping genes are more often controlled by intergenic enhancers, common to many tissues. Notably, an intergenic-to-intronic active enhancers continuum is observed in the transition from developmental to adult stages: the most differentiated tissues present higher rates of intronic enhancers, whereas the lowest rates are observed in embryonic stem cells. Altogether, our results suggest that the genomic location of active enhancers is key for the tissue-specific control of gene expression.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Cold Spring Harbor Laboratory Press (CSHL Press)
dc.relation.ispartof Genome Res. 2021;31(8):1325-36
dc.rights © 2021 Borsari et al.; Published by Cold Spring Harbor Laboratory Press. This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see https://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
dc.title Enhancers with tissue-specific activity are enriched in intronic regions
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1101/gr.270371.120
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/acceptedVersion


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