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Mapping the synchronization effect of gamma-aminobutyric acid inhibition on the cerebral cortex using magnetic resonance imaging

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dc.contributor.author Blanco Hinojo, Laura, 1981-
dc.contributor.author Pujol, Jesús
dc.contributor.author Macià, Dídac
dc.contributor.author Martínez-Vilavella, Gerard
dc.contributor.author Martín Santos, Rocío
dc.contributor.author Pérez Solá, Victor
dc.contributor.author Deus, Joan
dc.date.accessioned 2021-09-03T07:04:12Z
dc.date.issued 2021
dc.identifier.citation Blanco-Hinojo L, Pujol J, Macià D, Martínez-Vilavella G, Martín-Santos R, Pérez-Sola V, Deus J. Mapping the synchronization effect of gamma-aminobutyric acid inhibition on the cerebral cortex using magnetic resonance imaging. Brain Connect. 2021;11(5):393-403. DOI: 10.1089/brain.2020.0844
dc.identifier.issn 2158-0014
dc.identifier.uri http://hdl.handle.net/10230/48379
dc.description.abstract Background: Functional magnetic resonance imaging (fMRI) of spontaneous brain activity permits the identification of functional networks on the basis of region synchrony. The functional coupling between the elements of a neural system increases during brain activation. However, neural synchronization may also be the effect of inhibitory gamma-aminobutyric acid (GABA) neurons in states of brain inhibition such as sleep or pharmacological sedation. We investigated the effects of an oral dose of alprazolam, a classical benzodiazepine known to enhance inhibitory neurotransmission, using recently developed measures of local functional connectivity. Methods: In a randomized, double-blind, placebo-controlled, crossover design, 32 non-treatment-seeking individuals with social anxiety underwent two identical resting-state fMRI sessions on separate days after receiving 0.75 mg of alprazolam and placebo. Functional connectivity maps of the cerebral cortex were generated by using multidistance functional connectivity measures defined within iso-distant local areas. Results: Relative to placebo, increased intracortical functional connectivity was observed in the alprazolam condition in visual, auditory, and sensorimotor cortices, and in areas of sensory integration such as the posterior insula and orbitofrontal cortex (OFC). Alprazolam significantly reduced subjective arousal compared with placebo, and the change was associated with variations in multidistance functional connectivity measures in the OFC. Discussion: In conclusion, we report evidence that alprazolam significantly modifies neural activity coupling at rest in the form of functional connectivity enhancement within the cerebral cortex. The effect of alprazolam was particularly evident in the cortical sensory system, which would further suggest a differentiated effect of GABA inhibition on sensory processing.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Mary Ann Liebert, Inc
dc.relation.ispartof Brain Connect. 2021;11(5):393-403
dc.rights Final publication is available from Mary Ann Liebert, Inc., publishers http://dx.doi.org/10.1089/brain.2020.0844
dc.title Mapping the synchronization effect of gamma-aminobutyric acid inhibition on the cerebral cortex using magnetic resonance imaging
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1089/brain.2020.0844
dc.subject.keyword GABA
dc.subject.keyword Alprazolam
dc.subject.keyword Functional connectivity
dc.subject.keyword Inhibition
dc.subject.keyword Neuronal synchrony
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/acceptedVersion

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