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Evolutionary cell type mapping with single-cell genomics

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dc.contributor.author Tanay, Amos
dc.contributor.author Sebé-Pedrós, Arnau
dc.date.accessioned 2021-07-15T06:26:53Z
dc.date.issued 2021
dc.identifier.citation Tanay A, Sebé-Pedrós A. Evolutionary cell type mapping with single-cell genomics. Trends Genet. 2021 May 18:S0168-9525(21)00104-9. DOI: 10.1016/j.tig.2021.04.008
dc.identifier.issn 0168-9525
dc.identifier.uri http://hdl.handle.net/10230/48186
dc.description Data de publicació electrònica: 18-05-2021
dc.description.abstract A fundamental characteristic of animal multicellularity is the spatial coexistence of functionally specialized cell types that are all encoded by a single genome sequence. Cell type transcriptional programs are deployed and maintained by regulatory mechanisms that control the asymmetric, differential access to genomic information in each cell. This genome regulation ultimately results in specific cellular phenotypes. However, the emergence, diversity, and evolutionary dynamics of animal cell types remain almost completely unexplored beyond a few species. Single-cell genomics is emerging as a powerful tool to build comprehensive catalogs of cell types and their associated gene regulatory programs in non-traditional model species. We review the current state of sampling efforts across the animal tree of life and challenges ahead for the comparative study of cell type programs. We also discuss how the phylogenetic integration of cell atlases can lead to the development of models of cell type evolution and a phylogenetic taxonomy of cells.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof Trends Genet. 2021 May 18:S0168-9525(21)00104-9
dc.rights © Elsevier http://dx.doi.org/10.1016/j.tig.2021.04.008
dc.title Evolutionary cell type mapping with single-cell genomics
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1016/j.tig.2021.04.008
dc.rights.accessRights info:eu-repo/semantics/embargoedAccess
dc.type.version info:eu-repo/semantics/acceptedVersion
dc.embargo.liftdate 2022-05-18
dc.date.embargoEnd info:eu-repo/date/embargoEnd/2022-05-18

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