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Anti-myeloperoxidase and proteinase 3 antibodies for nephritis flare prediction in ANCA-associated-vasculitis

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dc.contributor.author Rodríguez, Eva
dc.contributor.author Latzke, Belén
dc.contributor.author Sierra Carpio, Milagros
dc.contributor.author Romera, Ana María
dc.contributor.author Siedel, Diego
dc.contributor.author Agraz, Irene
dc.contributor.author Soler, María José
dc.contributor.author García Carro, Clara
dc.contributor.author Draibe, Juliana
dc.contributor.author Prada, Francisco José de la
dc.contributor.author Villacorta, Javier
dc.contributor.author Buxeda, Anna
dc.contributor.author Sierra Ochoa, Adriana
dc.contributor.author Lozano, Inés
dc.contributor.author Durán, Xavier
dc.contributor.author Barrios Barrera, Clara
dc.contributor.author Pascual, Julio (Pascual Santos)
dc.contributor.author Spanish Group for the Study of Glomerular Diseases (GLOSEN)
dc.date.accessioned 2021-07-07T07:09:45Z
dc.date.issued 2022
dc.identifier.citation Rodríguez E, Latzke B, Sierra M, Romera AM, Siedel D, Agraz I et al. Anti-myeloperoxidase and proteinase 3 antibodies for nephritis flare prediction in ANCA-associated-vasculitis. Nephrol Dial Transplant. 2022;37(4):697-704. DOI: 10.1093/ndt/gfab020
dc.identifier.issn 0931-0509
dc.identifier.uri http://hdl.handle.net/10230/48101
dc.description.abstract Background: The value of myeloperoxidase and proteinase 3 antibodies titers in the assessment of renal disease activity and flare prediction in patients with ANCA-associated-vasculitis (AAV) is not well-known. Methods: Retrospective study including 113 AVV patients with a renal biopsy-proven pauci-immune necrotizing glomerulonephritis from seven Spanish hospitals. The main inclusion criteria were assessment of MPO antibodies (MPOab) using multiplex flow immunoassay and PR3 antibodies (PR3ab) measurements using immunoassay chemiluminescence with an identical range of values for all participating centers. Results: Serum MPOab, 3 ± 1.2 months before relapse, was higher in patients who relapsed (19.2 ± 12.2 vs 3.2 ± 5.1 AI, p < 0.001). The discrimination value of MPOab 3 months before renal relapse had an AUC of 0.82 (95%CI 0.73-0.92; p < 0.001). ΔMPOab (change in antibodies titration 6 months before relapse) was higher in patients who relapsed [8.3 ± 12 vs 0.9 ± 3.1 AI, p = 0.001) (AI; antibody index unit). The discrimination value of ΔMPO had an AUC of 0.76 (95%CI 0.63-0.88; p < 0.001). The positive predictive value of renal relapse in PR3 patients is 100% and the negative predictive value of renal relapse in patients with PR3 positive titers is 57.1%. Serum PR3ab was higher in patients who relapsed 2.8 ± 1.4 months before relapse (58.6 ± 24.6 vs 2.0 ± 0.6 AI, p < 0.001). Conclusions: MPO antibody level monitorization using multiplex flow immunoassay and PR3 measurements using immunoassay chemiluminescence are useful and sensitive tools for the prediction of renal relapse in the follow-up of AAV patients with renal disease, and relevant surrogate markers of renal disease activity.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Oxford University Press
dc.relation.ispartof Nephrol Dial Transplant. 2022;37(4):697-704
dc.rights © Oxford University Press. This is a pre-copyedited, author-produced version of an article accepted for publication in Nephrology, dialysis, transplantation following peer review. The version of record Rodríguez E, Latzke B, Sierra M, Romera AM, Siedel D, Agraz I et al. Antimyeloperoxidase and proteinase 3 antibodies for nephritis flare prediction in ANCA-associated-vasculitis. Nephrol Dial Transplant. 2021;37(4):697-704. DOI: 10.1093/ndt/gfab020 is available online at: http://dx.doi.org/10.1093/ndt/gfab020
dc.title Anti-myeloperoxidase and proteinase 3 antibodies for nephritis flare prediction in ANCA-associated-vasculitis
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1093/ndt/gfab020
dc.subject.keyword ANCA-associated vasculitides
dc.subject.keyword Myeloperoxidase antibodies
dc.subject.keyword Pauci-immune necrotizing glomerulonephritis flare
dc.subject.keyword Proteinase-3 antibodies
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/acceptedVersion

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