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Prognostic implications of chronic heart failure and utility of NT-proBNP levels in heart failure patients with SARS-CoV-2 infection

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dc.contributor.author Belarte Tornero, Laia Carla
dc.contributor.author Valdivielso Moré, Sandra
dc.contributor.author Vicente Elcano, Miren
dc.contributor.author Solé-González, Eduard
dc.contributor.author Ruíz Bustillo, Sonia
dc.contributor.author Calvo-Fernández, Alicia
dc.contributor.author Subirana Cachinero, Isaac
dc.contributor.author Cabero, Paula
dc.contributor.author Soler, Cristina
dc.contributor.author Cubero Gallego, Héctor
dc.contributor.author Vaquerizo Montilla, Beatriz
dc.contributor.author Farré López, Núria
dc.date.accessioned 2021-07-01T07:36:49Z
dc.date.available 2021-07-01T07:36:49Z
dc.date.issued 2021
dc.identifier.citation Belarte-Tornero LC, Valdivielso-Moré S, Vicente Elcano M, Solé-González E, Ruíz-Bustillo S, Calvo-Fernández A, Subinara I, Cabero P, Soler C, Cubero-Gallego H, Vaquerizo B, Farré N. Prognostic implications of chronic heart failure and utility of NT-proBNP levels in heart failure patients with SARS-CoV-2 infection. J Clin Med. 2021;10(2):323. DOI: 10.3390/jcm10020323
dc.identifier.issn 2077-0383
dc.identifier.uri http://hdl.handle.net/10230/48033
dc.description.abstract Background: The prevalence and prognostic value of chronic heart failure (CHF) in the setting of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection has seldom been studied. The aim of this study was to analyze the prevalence and prognosis of CHF in this setting. Methods: This single-center study included 829 consecutive patients with SARS-CoV-2 infection from February to April 2020. Patients with a previous history of CHF were matched 1:2 for age and sex. We analyze the prognostic value of pre-existing CHF. Prognostic implications of N terminal pro brain natriuretic peptide (NT-proBNP) levels on admission in the CHF cohort were explored. Results: A total of 129 patients (43 CHF and 86 non-CHF) where finally included. All-cause mortality was higher in CHF patients compared to non-CHF patients (51.2% vs. 29.1%, p = 0.014). CHF was independently associated with 30-day mortality (hazard ratio (HR) 2.3, confidence interval (CI) 95%: 1.26-2.4). Patients with CHF and high-sensitivity troponin T < 14 ng/L showed excellent prognosis. An NT-proBNP level > 2598 pg/mL on admission was associated with higher 30-day mortality in patients with CHF. Conclusions: All-cause mortality in CHF patients hospitalized due to SARS-CoV-2 infection was 51.2%. CHF was independently associated with all-cause mortality (HR 2.3, CI 95% 1.26-4.2). NT-proBNP levels could be used for stratification risk purposes to guide medical decisions if larger studies confirm this finding.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher MDPI
dc.relation.ispartof J Clin Med. 2021;10(2):323
dc.rights © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Prognostic implications of chronic heart failure and utility of NT-proBNP levels in heart failure patients with SARS-CoV-2 infection
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.3390/jcm10020323
dc.subject.keyword COVID-19
dc.subject.keyword NT-proBNP
dc.subject.keyword SARS-CoV-2
dc.subject.keyword Biomarkers
dc.subject.keyword Coronavirus
dc.subject.keyword Heart failure
dc.subject.keyword Prognosis
dc.subject.keyword Troponin
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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