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Do pregnancy-induced brain changes reverse? The brain of a mother six years after parturition

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dc.contributor.author Martínez-García, Magdalena
dc.contributor.author Paternina Die, María
dc.contributor.author Barba-Müller, Erika
dc.contributor.author Martín de Blas, Daniel
dc.contributor.author Beumala, Laura
dc.contributor.author Cortizo Vidal, Romina
dc.contributor.author Pozzobon, Cristina
dc.contributor.author Marcos-Vidal, Luis
dc.contributor.author Fernández Pena, Alberto
dc.contributor.author Picado, Marisol
dc.contributor.author Belmonte Padilla, Elena
dc.contributor.author Massó Rodriguez, Anna
dc.contributor.author Ballesteros, Agustín
dc.contributor.author Desco, Manuel
dc.contributor.author Vilarroya, Óscar
dc.contributor.author Hoekzema, Elseline
dc.contributor.author Carmona, Susanna
dc.date.accessioned 2021-06-28T07:37:08Z
dc.date.available 2021-06-28T07:37:08Z
dc.date.issued 2021
dc.identifier.citation Martínez-García M, Paternina-Die M, Barba-Müller E, Martín de Blas D, Beumala L, Cortizo R, Pozzobon C, Marcos-Vidal L, Fernández-Pena A, Picado M, Belmonte-Padilla E, Massó-Rodriguez A, Ballesteros A, Desco M, Vilarroya Ó, Hoekzema E, Carmona S. Do pregnancy-induced brain changes reverse? The brain of a mother six years after parturition. Brain Sci. 2021;11(2):168. DOI: 10.3390/brainsci11020168
dc.identifier.issn 2076-3425
dc.identifier.uri http://hdl.handle.net/10230/47985
dc.description.abstract Neuroimaging researchers commonly assume that the brain of a mother is comparable to that of a nulliparous woman. However, pregnancy leads to pronounced gray matter volume reductions in the mother's brain, which have been associated with maternal attachment towards the baby. Beyond two years postpartum, no study has explored whether these brain changes are maintained or instead return to pre-pregnancy levels. The present study tested whether gray matter volume reductions detected in primiparous women are still present six years after parturition. Using data from a unique, prospective neuroimaging study, we compared the gray matter volume of 25 primiparous and 22 nulliparous women across three sessions: before conception (n = 25/22), during the first months of postpartum (n = 25/21), and at six years after parturition (n = 7/5). We found that most of the pregnancy-induced gray matter volume reductions persist six years after parturition (classifying women as having been pregnant or not with 91.67% of total accuracy). We also found that brain changes at six years postpartum are associated with measures of mother-to-infant attachment. These findings open the possibility that pregnancy-induced brain changes are permanent and encourage neuroimaging studies to routinely include pregnancy-related information as a relevant demographic variable.
dc.description.sponsorship This work was supported by Ministerio de Ciencia, Innovación y Universidades project RTI2018-093952-B-100 and by Instituto de Salud Carlos III projects CP16/00096 and PI17/00064, and co-funded by European Regional Development Fund (ERDF), “A way of making Europe.” The project exAScale ProgramIng models for extreme Data procEssing (ASPIDE) has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No 801091. M.M.-G. and S.C. were funded by Ministerio de Ciencia, Innovación y Universidades, Instituto de Salud Carlos III, Predoctorales de Formación en Investigación en Salud (PFIS), contract FI18/00255 and Miguel Servet Type I research contract CP16/00096, respectively) and co-funded by European Social Fund “Investing in your future.” M.P.-D. was supported by Consejería de Educación e Investigación, Comunidad de Madrid, co-funded by European Social Fund “Investing in your future” (PEJD-2018-PRE/BMD-9401). The project leading to these results has received funding from “la Caixa” Foundation under the project code LCF/PR/HR19/52160001. The Centro Nacional de Investigaciones Cardiovasculares (CNIC) is supported by the Ministerio de Ciencia, Innovación y Universidades, and the Pro CNIC Foundation, and is a Severo Ochoa Center of Excellence (SEV-2015-0505).
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher MDPI
dc.relation.ispartof Brain Sci. 2021;11(2):168
dc.rights © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Do pregnancy-induced brain changes reverse? The brain of a mother six years after parturition
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.3390/brainsci11020168
dc.subject.keyword Magnetic resonance imaging
dc.subject.keyword Maternal brain
dc.subject.keyword Neuroplasticity
dc.subject.keyword Postpartum
dc.subject.keyword Pregnancy
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/801091
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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