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Exploring the role of breast density on cancer prognosis among women attending population-based screening programmes

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dc.contributor.author Domingo Torrell, Laia
dc.contributor.author Sala Serra, Maria
dc.contributor.author Louro, Javier
dc.contributor.author Baré, Marisa
dc.contributor.author Barata, Teresa
dc.contributor.author Ferrer, Joana
dc.contributor.author Carmona-Garcia, Maria Carmen
dc.contributor.author Comas Serrano, Mercè
dc.contributor.author Castells, Xavier
dc.contributor.author CAMISS Study Group
dc.date.accessioned 2021-03-26T07:54:19Z
dc.date.available 2021-03-26T07:54:19Z
dc.date.issued 2019
dc.identifier.citation Domingo L, Sala M, Louro J, Baré M, Barata T, Ferrer J, et al. Exploring the role of breast density on cancer prognosis among women attending population-based screening programmes. J Oncol. 2019 Nov 27; 2019:1781762. DOI: 10.1155/2019/1781762
dc.identifier.issn 1687-8450
dc.identifier.uri http://hdl.handle.net/10230/46947
dc.description.abstract Background: Our aim was to assess the role of breast density on breast cancer mortality and recurrences, considering patient and tumour characteristics and the treatments received among women attending population-based screening programmes. Methods: We conducted a retrospective cohort study among women aged 50-69 years attending population-based screening programmes, diagnosed with invasive breast cancer between 2000 and 2009, and followed up to 2014. Breast density was categorised as low density (≤25% dense tissue), intermediate density (25-50%), and high density (≥50%). Cox proportional hazards regression models were fitted to estimate the adjusted hazard ratios (aHR) and 95% confidence intervals (95% CI) for death and recurrences, adjusting by patient characteristics, mode of detection (screen-detected vs. interval cancer), and tumour features. Results: The percentage of deaths and recurrences was higher among women with intermediate- and high-density breasts than among women with low-density breasts (p=0.011 for death; p=0.037 for recurrences). Adjusted Cox proportional hazards regression models revealed that women with intermediate- and high-density breasts had a higher risk of death than women with low-density breasts, being statistically significant for intermediate densities (aHR = 2.19 [95% CI: 1.16-4.13], aHR = 1.44 [95% CI: 0.67-3.1], respectively). No association was found between breast density and recurrences. Conclusions: Breast density was associated with a higher risk of death, but not of recurrences, among women participating in breast cancer screening. These findings reinforce the need to improve screening sensitivity among women with dense breasts and to routinely assess breast density, not only for its role as a risk factor for breast cancer but also for its potential influence on cancer prognosis.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Hindawi
dc.rights Copyright © 2019 Laia Domingo et al. This is an open access article distributed under the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.subject.other Càncer--Prognosi
dc.subject.other Mama--Càncer--Prognosi
dc.subject.other Càncer--Mortalitat
dc.title Exploring the role of breast density on cancer prognosis among women attending population-based screening programmes
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1155/2019/1781762
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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