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Trafficking of stretch-regulated TRPV2 and TRPV4 channels inferred through interactomics

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dc.contributor.author Doñate-Macián, Pau
dc.contributor.author Enrich-Bengoa, Jennifer
dc.contributor.author Dégano, Irene R.
dc.contributor.author Quintana, David G.
dc.contributor.author Perálvarez Marín, Alex
dc.date.accessioned 2021-03-15T07:39:33Z
dc.date.available 2021-03-15T07:39:33Z
dc.date.issued 2019
dc.identifier.citation Doñate-Macián P, Enrich-Bengoa J, Dégano IR, Quintana DG, Perálvarez-Marín A. Trafficking of stretch-regulated TRPV2 and TRPV4 channels inferred through interactomics. Biomolecules. 2019 Nov 27; 9(12): 791. DOI: 10.3390/biom9120791
dc.identifier.issn 2218-273X
dc.identifier.uri http://hdl.handle.net/10230/46760
dc.description.abstract Transient receptor potential cation channels are emerging as important physiological and therapeutic targets. Within the vanilloid subfamily, transient receptor potential vanilloid 2 (TRPV2) and 4 (TRPV4) are osmo- and mechanosensors becoming critical determinants in cell structure and activity. However, knowledge is scarce regarding how TRPV2 and TRPV4 are trafficked to the plasma membrane or specific organelles to undergo quality controls through processes such as biosynthesis, anterograde/retrograde trafficking, and recycling. This review lists and reviews a subset of protein-protein interactions from the TRPV2 and TRPV4 interactomes, which is related to trafficking processes such as lipid metabolism, phosphoinositide signaling, vesicle-mediated transport, and synaptic-related exocytosis. Identifying the protein and lipid players involved in trafficking will improve the knowledge on how these stretch-related channels reach specific cellular compartments.
dc.description.sponsorship This work was supported by Marie Curie International Outgoing Fellowship within the 7th European Community Framework Programme (PIOF-GA-2009-237120 to A.P.-M.), a Universitat Autònoma de Barcelona-Programa Banco de Santander Fellowship, and the Spanish Government grant MINECO BFU2017-87843-R to A.P.-M. P.D.-M. was a recipient of an FI fellowship from Generalitat de Catalunya (FI-2013FIB00251). I.R.D. was supported by the Carlos III Health Institute, co-financed with European Union European Regional Development Funds (CIBERCV CB16/11/00229), and by the Strategic Plan for research and health innovation (PERIS) (SLT006/17/00029).
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher MDPI
dc.relation.ispartof Biomolecules. 2019 Nov 27; 9(12): 791
dc.rights Copyright © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Trafficking of stretch-regulated TRPV2 and TRPV4 channels inferred through interactomics
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.3390/biom9120791
dc.subject.keyword TRPV2
dc.subject.keyword TRPV4
dc.subject.keyword Ion channel trafficking
dc.subject.keyword Phosphatidylinositol signaling
dc.subject.keyword Stretch-related channels
dc.subject.keyword Transient receptor potential channels
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/237120
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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