Trafficking of stretch-regulated TRPV2 and TRPV4 channels inferred through interactomics

Doñate-Macián, Pau; Enrich-Bengoa, Jennifer; Dégano, Irene R.; Quintana, David G.; Perálvarez Marín, Alex

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dc.contributor.author	Doñate-Macián, Pau
dc.contributor.author	Enrich-Bengoa, Jennifer
dc.contributor.author	Dégano, Irene R.
dc.contributor.author	Quintana, David G.
dc.contributor.author	Perálvarez Marín, Alex
dc.date.accessioned	2021-03-15T07:39:33Z
dc.date.available	2021-03-15T07:39:33Z
dc.date.issued	2019
dc.identifier.citation	Doñate-Macián P, Enrich-Bengoa J, Dégano IR, Quintana DG, Perálvarez-Marín A. Trafficking of stretch-regulated TRPV2 and TRPV4 channels inferred through interactomics. Biomolecules. 2019 Nov 27; 9(12): 791. DOI: 10.3390/biom9120791
dc.identifier.issn	2218-273X
dc.identifier.uri	http://hdl.handle.net/10230/46760
dc.description.abstract	Transient receptor potential cation channels are emerging as important physiological and therapeutic targets. Within the vanilloid subfamily, transient receptor potential vanilloid 2 (TRPV2) and 4 (TRPV4) are osmo- and mechanosensors becoming critical determinants in cell structure and activity. However, knowledge is scarce regarding how TRPV2 and TRPV4 are trafficked to the plasma membrane or specific organelles to undergo quality controls through processes such as biosynthesis, anterograde/retrograde trafficking, and recycling. This review lists and reviews a subset of protein-protein interactions from the TRPV2 and TRPV4 interactomes, which is related to trafficking processes such as lipid metabolism, phosphoinositide signaling, vesicle-mediated transport, and synaptic-related exocytosis. Identifying the protein and lipid players involved in trafficking will improve the knowledge on how these stretch-related channels reach specific cellular compartments.
dc.description.sponsorship	This work was supported by Marie Curie International Outgoing Fellowship within the 7th European Community Framework Programme (PIOF-GA-2009-237120 to A.P.-M.), a Universitat Autònoma de Barcelona-Programa Banco de Santander Fellowship, and the Spanish Government grant MINECO BFU2017-87843-R to A.P.-M. P.D.-M. was a recipient of an FI fellowship from Generalitat de Catalunya (FI-2013FIB00251). I.R.D. was supported by the Carlos III Health Institute, co-financed with European Union European Regional Development Funds (CIBERCV CB16/11/00229), and by the Strategic Plan for research and health innovation (PERIS) (SLT006/17/00029).
dc.format.mimetype	application/pdf
dc.language.iso	eng
dc.publisher	MDPI
dc.relation.ispartof	Biomolecules. 2019 Nov 27; 9(12): 791
dc.rights	Copyright © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/
dc.title	Trafficking of stretch-regulated TRPV2 and TRPV4 channels inferred through interactomics
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	http://dx.doi.org/10.3390/biom9120791
dc.subject.keyword	TRPV2
dc.subject.keyword	TRPV4
dc.subject.keyword	Ion channel trafficking
dc.subject.keyword	Phosphatidylinositol signaling
dc.subject.keyword	Stretch-related channels
dc.subject.keyword	Transient receptor potential channels
dc.relation.projectID	info:eu-repo/grantAgreement/EC/FP7/237120
dc.rights.accessRights	info:eu-repo/semantics/openAccess
dc.type.version	info:eu-repo/semantics/publishedVersion