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From green technology to functional olive oils: assessing the best combination of olive tree-related extracts with complementary bioactivities

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dc.contributor.author Hernáez, Álvaro
dc.contributor.author Jaramillo, Sara
dc.contributor.author García Borrego, Aránzazu
dc.contributor.author Espejo-Calvo, Juan A.
dc.contributor.author Covas Planells, Maria Isabel
dc.contributor.author Blanchart, Gemma
dc.contributor.author Torre Fornell, Rafael de la
dc.contributor.author Carrasco-Pancorbo, Alegría
dc.contributor.author Mesa, Maria-Dolores
dc.contributor.author Fernández Prior, Maria África
dc.contributor.author Castañer, Olga
dc.contributor.author Fitó Colomer, Montserrat
dc.date.accessioned 2021-03-05T07:44:49Z
dc.date.available 2021-03-05T07:44:49Z
dc.date.issued 2021
dc.identifier.citation Hernáez Á, Jaramillo S, García-Borrego A, Espejo-Calvo JA, Covas MI, Blanchart G, de la Torre R, Carrasco-Pancorbo A, Mesa MD, Fernández-Prior MÁ, Castañer O, Fitó M. From green technology to functional olive oils: assessing the best combination of olive tree-related extracts with complementary bioactivities. Antioxidants (Basel). 2021; 10(2):202. DOI: 10.3390/antiox10020202
dc.identifier.issn 2076-3921
dc.identifier.uri http://hdl.handle.net/10230/46674
dc.description.abstract Our aim was to assess the combination of olive tree-related extracts with the most favorable profile of in vitro bioactive properties. We tested the antioxidant (increment of low-density lipoprotein resistance against oxidation), vasoactive (promotion of nitric oxide release and decrease of endothelin-1 production in human umbilical vein endothelial cells), anti-inflammatory (decrease of the endothelial production of vascular cell adhesion molecule-1), and antithrombotic (reduction of the endothelial release of plasminogen activator inhibitor-1) capacities of six phenolic extracts and three triterpenic acid solutions (Ps and Ts, respectively). We tested extracts alone and in combination, at nutritional (Ps: 0.05-0.5 μmol/L; Ts: 0.001-0.1 μmol/L) and nutraceutical doses (Ps: 1-10 μmol/L; Ts: 0.25-10 μmol/L). The combination of Ps rich in 3,4-dihydroxyphenylglycol (76%, P2), hydroxytyrosol (95%, P3), and oleuropein (70%, P4) (final nutritional concentration: 0.15 μmol/L; final nutraceutical concentration: 3 μmol/L) was the best in order to prepare functional products and nutraceuticals with cardioprotective properties, despite the fact that the isolated extract with the greatest in vitro properties was P5 (75% oleocanthal), suggesting a potential synergistic effect among different olive components.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher MDPI
dc.relation.ispartof Antioxidants (Basel). 2021; 10(2):202
dc.rights © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title From green technology to functional olive oils: assessing the best combination of olive tree-related extracts with complementary bioactivities
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.3390/antiox10020202
dc.subject.keyword 3,4-dihydroxyphenylglycol
dc.subject.keyword Bioactivity
dc.subject.keyword Functional olive oil
dc.subject.keyword Hydroxytyrosol
dc.subject.keyword Oleocanthal
dc.subject.keyword Oleuropein
dc.subject.keyword Olive tree
dc.subject.keyword Phenolic compound
dc.subject.keyword Triterpenes
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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