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The nucleus measures shape changes for cellular proprioception to control dynamic cell behavior

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dc.contributor.author Venturini, Valeria
dc.contributor.author Pezzano, Fabio
dc.contributor.author Català Castro, Frederic
dc.contributor.author Häkkinen, Hanna-Maria
dc.contributor.author Jiménez-Delgado, Senda
dc.contributor.author Colomer-Rosell, Mariona
dc.contributor.author Marro, Monica
dc.contributor.author Tolosa-Ramon, Queralt
dc.contributor.author Paz-López, Sonia
dc.contributor.author Valverde, M. A. (Miguel Ángel), 1963-
dc.contributor.author Weghuber, Julian
dc.contributor.author Loza-Alvarez, Pablo
dc.contributor.author Krieg, Michael
dc.contributor.author Wieser, Stefan
dc.contributor.author Ruprecht, Verena
dc.date.accessioned 2021-02-08T11:33:02Z
dc.date.available 2021-02-08T11:33:02Z
dc.date.issued 2020
dc.identifier.citation Venturi V, Pezzano F, Català Castro F, Häkkinen HM, Jiménez-Delgado S, Colomer-Rosell M et al. Science. 2020 Oct 16; 370(6514): eaba2644. DOI: 10.1126/science.aba2644
dc.identifier.issn 0036-8075
dc.identifier.uri http://hdl.handle.net/10230/46386
dc.description.abstract The physical microenvironment regulates cell behavior during tissue development and homeostasis. How single cells decode information about their geometrical shape under mechanical stress and physical space constraints within tissues remains largely unknown. Here, using a zebrafish model, we show that the nucleus, the biggest cellular organelle, functions as an elastic deformation gauge that enables cells to measure cell shape deformations. Inner nuclear membrane unfolding upon nucleus stretching provides physical information on cellular shape changes and adaptively activates a calcium-dependent mechanotransduction pathway, controlling actomyosin contractility and migration plasticity. Our data support that the nucleus establishes a functional module for cellular proprioception that enables cells to sense shape variations for adapting cellular behavior to their microenvironment.
dc.description.sponsorship Funding: V.V. acknowledges support from the ICFOstepstone PhD Programme funded by the European Union’s Horizon 2020 research and innovation program under Marie Skłodowska-Curie grant agreement 665884. F.P. and Q.T.-R. acknowledge grants funded by Ministerio de Ciencia, Innovación y Universidades and Fondo Social Europeo (FSE) (BES2017-080523-SO, PRE2018-084393). M.A.V. acknowledges support from the Spanish Ministry of Science, Education and Universities through grant RTI2018-099718-B-100 and an institutional “Maria de Maeztu Programme” for Units of Excellence in R&D (CEX2018-000792-M) and FEDER funds.S.W. and M.K. acknowledge support from the Spanish Ministry of Economy and Competitiveness through the Severo Ochoa program for Centres of Excellence in R&D (CEX2019-000910-S), from Fundació Privada Cellex, Fundación Mig-Puig, and from Generalitat de Catalunya through the CERCA program and LaserLab (654148). M.K. acknowledges support through Spanish Ministry of Economy and Competitiveness (RYC-2015-17935, EQC2018-005048-P, AEI-010500-2018-228, and PGC2018-097882-A-I00),Generalitat de Catalunya (2017 SGR 1012), the ERC (715243), and the HFSPO (CDA00023/2018). S.W. acknowledges support through the Spanish Ministry of Economy and Competitiveness via MINECO’s Plan Nacional (PGC2018-098532-A-I00). V.R. acknowledges support from the Spanish Ministry of Science and Innovation to the EMBL partnership, the Centro de Excelencia Severo Ochoa, the CERCA Programme/Generalitat de Catalunya, and the MINECO’s Plan Nacional (BFU2017-86296-P)
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher American Association for the Advancement of Science (AAAS)
dc.relation.ispartof Science. 2020 Oct 16; 370(6514): eaba2644
dc.rights © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works
dc.subject.other Genètica
dc.subject.other Cèl·lules
dc.title The nucleus measures shape changes for cellular proprioception to control dynamic cell behavior
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1126/science.aba2644
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/665884
dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/RYC2015-17935
dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/BFU2017-86296-P
dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/BES2017-080523-SO
dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/EQC2018-005048-P
dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PGC2018-097882-A-I00
dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PGC2018-098532-A-I00
dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PRE2018-084393
dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/RTI2018-099718-B-100
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/acceptedVersion

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