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Transcriptomic analysis of micropapillary high grade T1 urothelial bladder cancer

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dc.contributor.author Bowden, Michaela
dc.contributor.author Nadal, Rosa
dc.contributor.author Zhou, Chensheng W.
dc.contributor.author Werner, Lillian
dc.contributor.author Barletta, Justine A.
dc.contributor.author Juanpere, Nuria
dc.contributor.author Lloreta Trull, Josep, 1958-
dc.contributor.author Hernández Llodrà, Silvia
dc.contributor.author Morote, Juan
dc.contributor.author Torres, Inés de
dc.contributor.author Orsola, Anna
dc.contributor.author Cejas, Paloma
dc.contributor.author Long, Henry
dc.contributor.author Bellmunt Molins, Joaquim, 1959-
dc.date.accessioned 2020-12-15T08:08:01Z
dc.date.available 2020-12-15T08:08:01Z
dc.date.issued 2020
dc.identifier.citation Bowden M, Nadal R, Zhou CW, Werner L, Barletta J, Juanpere N, Lloreta J, Hernandez-Llodrà S, Morote J, de Torres I, Orsola A, Cejas P, Long H, Bellmunt J. Transcriptomic analysis of micropapillary high grade T1 urothelial bladder cancer. Sci Rep. 2020; 10(1):20135. DOI: 10.1038/s41598-020-76904-7
dc.identifier.issn 2045-2322
dc.identifier.uri http://hdl.handle.net/10230/46041
dc.description.abstract No consensus currently exist on the optimal treatment of patients with high-risk nonmuscle invasive (HGT1) micropapillary variant of bladder cancer (MPBC). Transcripsome analysis may allow stratification of MPBC-HGT1 enabling prediction of recurrence and guide therapeutic management for individual patients. Whole transcriptome RNA-Sequencing of tumors from 23 patients with MPBC-HGT1 and 64 conventional urothelial carcinomas (cUC) (reference set) was performed. Differentially expressed genes between MPBC-HGT1 and cUC-HGT1 were explored. Cox proportional hazard models and Kapplan-Meier methods were used to assess the relation between time to progression (TTP) and individual gene expression adjusting for clinical covariates. Over 3000 genes were differentially expressed in MPBC-HGT1 as compared with cUC-HGT1 and a 26-gene signature is characteristic of MPBC within HGT1. A set of three genes; CD36, FAPB3 and RAETE1; were significantly associated with TTP. High expression of FABP3 and CD36 were associated with shorter TTP (p = 0.045 and p = 0.08) as was low expression of RAET1E (p = 0.01). Our study suggest that a 26-gene signature can define MPBC-HGT1 within conventional urothelial carcinomas. A prognostic risk index of three genes (FABP3, CD36 and RAET1E) was found to be associated with shorter TTP and may help classify a group of patients with MPBC-HGT1 with high-risk of early progression. These observations might have implications in terms of radical cystectomy recommendation in MPBC patients.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Nature Research
dc.relation.ispartof Sci Rep. 2020; 10(1):20135
dc.rights © The Author(s) 2020. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Transcriptomic analysis of micropapillary high grade T1 urothelial bladder cancer
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1038/s41598-020-76904-7
dc.subject.keyword Biomarkers
dc.subject.keyword Medical research
dc.subject.keyword Molecular medicine
dc.subject.keyword Oncology
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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