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Expanding the geographic characterisation of epstein-barr virus variation through gene-based approaches

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dc.contributor.author Telford, Marco, 1984-
dc.contributor.author Hughes, David
dc.contributor.author Juan, David
dc.contributor.author Stoneking, Mark
dc.contributor.author Navarro i Cuartiellas, Arcadi, 1969-
dc.contributor.author Santpere Baró, Gabriel, 1981-
dc.date.accessioned 2020-12-14T06:56:29Z
dc.date.available 2020-12-14T06:56:29Z
dc.date.issued 2020
dc.identifier.citation Telford M, Hughes DA, Juan D, Stoneking M, Navarro A, Santpere G. Expanding the geographic characterisation of epstein-barr virus variation through gene-based approaches. Microorganisms. 2020; 8(11):1686. DOI: 10.3390/microorganisms8111686
dc.identifier.issn 2076-2607
dc.identifier.uri http://hdl.handle.net/10230/46004
dc.description.abstract The Epstein-Barr Virus (EBV) infects the vast majority of human individuals worldwide (~90%) and is associated with several diseases, including different types of cancer and multiple sclerosis, which show wide variation in incidence among global geographical regions. Genetic variants in EBV genomic sequences have been used to determine the geographical structure of EBV isolates, but our understanding of EBV diversity remains highly incomplete. We generated sequences for 13 pivotal EBV genes derived from 103 healthy individuals, expanding current EBV diversity datasets with respect to both geographic coverage and number of isolates per region. These newly generated sequences were integrated with the more than 250 published EBV genomes, generating the most geographically comprehensive data set of EBV strains to date. We report remarkable variation in single-gene phylogenies that, when analysed together, show robust signals of population structure. Our results not only confirm known major global patterns of geographic variation, such as the clear separation of Asian isolates from the rest, and the intermixed relationships among African, European and Australian isolates, but yield novel phylogenetic relationships with previously unreported populations. We provide a better understanding of EBV's population structure in South America, Africa and, by the inclusion of Turkey and Georgia, we also gain insight into EBV diversity in Western Asia, a crossroads connecting Europe, Africa and Asia. In summary, our results provide a detailed world-wide characterisation of EBV genetic clusters, their enrichment in specific geographic regions, novel inter-population relationships, and a catalogue of geographically informative EBV genetic variants.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher MDPI
dc.relation.ispartof Microorganisms. 2020; 8(11):1686
dc.rights © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Expanding the geographic characterisation of epstein-barr virus variation through gene-based approaches
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.3390/microorganisms8111686
dc.subject.keyword Esptein–Barr virus
dc.subject.keyword Gene
dc.subject.keyword Genetic diversity
dc.subject.keyword Genomics
dc.subject.keyword Human herpes virus 4
dc.subject.keyword Phylogeny
dc.subject.keyword Phylogeography
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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