Welcome to the UPF Digital Repository

Cancer stem cells and epithelial-to-mesenchymal transition in cancer metastasis

Show simple item record

dc.contributor.author Celià-Terrassa, Toni
dc.contributor.author Jolly, Mohit Kumar
dc.date.accessioned 2020-05-11T07:10:46Z
dc.date.available 2020-05-11T07:10:46Z
dc.date.issued 2020
dc.identifier.citation Celià-Terrassa T, Jolly MK. Cancer stem cells and epithelial-to-mesenchymal transition in cancer metástasis. Cold Spring Harb Perspect Med. 2020 Jul 1; 10(7):a036905. DOI: 10.1101/cshperspect.a036905
dc.identifier.issn 2157-1422
dc.identifier.uri http://hdl.handle.net/10230/44473
dc.description Data de publicació electrónica: 30-09-2019
dc.description.abstract The cancer stem cell (CSC) concept stands for undifferentiated tumor cells with the ability to initiate heterogeneous tumors. It is also relevant in metastasis and can explain how metastatic tumors mirror the heterogeneity of primary tumors. Cellular plasticity, including the epithelial-to-mesenchymal transition (EMT), enables the generation of CSCs at different steps of the metastatic process including metastatic colonization. In this review, we update the concept of CSCs and provide evidence of the existence of metastatic stem cells (MetSCs). In addition, we highlight the nuanced understanding of EMT that has been gained recently and the association of mesenchymal-to-epithelial transition (MET) with the acquisition of CSCs properties during metastasis. We also comment on the computational approaches that have profoundly influenced our understanding of CSCs and EMT; and how these studies and new experimental technologies can yield a deeper understanding of the biological aspects of metastasis.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Cold Spring Harbor Laboratory Press (CSHL Press)
dc.rights Published originally by Cold Spring Harbor Laboratory Press at 10.1101/cshperspect.a036905. Beginning six months from the full-issue publication date, articles are distributed under the Creative Commons Attribution-Non-Commercial 4.0 International License (CC-BY-NC), as described at http://creativecommons.org/licenses/by-nc/4.0/. This license permits non-commercial use, including reproduction, adaptation, and distribution of the article provided the original author and source are credited.
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.subject.other Metàstasi -- Aspectes genètics
dc.subject.other Metàstasi limfàtica
dc.subject.other Càncer -- Aspectes genètics
dc.title Cancer stem cells and epithelial-to-mesenchymal transition in cancer metastasis
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1101/cshperspect.a036905
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

Thumbnail

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Advanced Search

Browse

My Account

Statistics

In collaboration with Compliant to Partaking