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Sensory-to-cognitive systems integration is associated with clinical severity in autism spectrum disorder

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dc.contributor.author Martínez, Kenia
dc.contributor.author Martínez-García, Magdalena
dc.contributor.author Marcos-Vidal, Luis
dc.contributor.author Janssen, Joost
dc.contributor.author Castellanos, Francisco X.
dc.contributor.author Petrus, Clara
dc.contributor.author Vilarroya, Óscar
dc.contributor.author Pina-Camacho, Laura
dc.contributor.author Díaz-Caneja, Covadonga M.
dc.contributor.author Parellada, Mara
dc.contributor.author Arango, Celso
dc.contributor.author Desco, Manuel
dc.contributor.author Sepulcre, Jorge
dc.contributor.author Carmona, Susanna
dc.date.accessioned 2020-04-21T06:50:34Z
dc.date.issued 2020
dc.identifier.citation Martínez K, Martínez-García M, Marcos-Vidal L, Janssen J, Castellanos FX, Pretus C, et al. Sensory-to-cognitive systems integration is associated with clinical severity in autism spectrum disorder. J Am Acad Child Adolesc Psychiatry. 2020 Mar;59(3):422-33. DOI: 10.1016/j.jaac.2019.05.033
dc.identifier.issn 0890-8567
dc.identifier.uri http://hdl.handle.net/10230/44281
dc.description.abstract Objective: Impaired multisensory integration in autism spectrum disorder (ASD) may arise from functional dysconnectivity among brain systems. Our study examines the functional connectivity integration between primary modal sensory regions and heteromodal processing cortex in ASD, and whether abnormalities in network integration relate to clinical severity. Method: We studied a sample of 55 high-functioning ASD and 64 healthy control (HC) male children and adolescents (total n = 119, age range 7-18 years). Stepwise functional connectivity analysis (SFC) was applied to resting state functional magnetic resonance images (rsfMRI) to characterize the connectivity paths that link primary sensory cortices to higher-order brain cognitive functional circuits and to relate alterations in functional connectivity integration with three clinical scales: Social Communication Questionnaire, Social Responsiveness Scale, and Vineland Adaptive Behavior Scales. Results: HC displayed typical functional connectivity transitions from primary sensory systems to association areas, but the ASD group showed altered patterns of multimodal sensory integration to heteromodal systems. Specifically, compared to the HC group, the ASD group showed the following: (1) hyperconnectivity in the visual cortex at initial link step distances; (2) hyperconnectivity between sensory unimodal regions and regions of the default mode network; and (3) hypoconnectivity between sensory unimodal regions and areas of the fronto-parietal and attentional networks. These patterns of hyper- and hypoconnectivity were associated with increased clinical severity in ASD. Conclusion: Networkwise reorganization in high-functioning ASD individuals affects strategic regions of unimodal-to-heteromodal cortical integration predicting clinical severity. In addition, SFC analysis appears to be a promising approach for studying the neural pathophysiology of multisensory integration deficits in ASD.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.rights © Elsevier http://dx.doi.org/10.1016/j.jaac.2019.05.033
dc.title Sensory-to-cognitive systems integration is associated with clinical severity in autism spectrum disorder
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1016/j.jaac.2019.05.033
dc.subject.keyword Autism spectrum disorder
dc.subject.keyword Default mode network
dc.subject.keyword Fronto-parietal networks
dc.subject.keyword Multisensory integration
dc.subject.keyword Resting-state functional magnetic resonance imaging
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/acceptedVersion


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