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Effect modification of FADS2 polymorphisms on the association between breastfeeding and intelligence: results from a collaborative meta-analysis

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dc.contributor.author Pires Hartwig, Fernando
dc.contributor.author Dalmau Bueno, Albert
dc.contributor.author Guxens Junyent, Mònica
dc.contributor.author Bustamante Pineda, Mariona
dc.contributor.author Gomes Victora, Cesar
dc.date.accessioned 2020-03-27T07:23:58Z
dc.date.available 2020-03-27T07:23:58Z
dc.date.issued 2019
dc.identifier.citation Hartwig FP, Davies NM, Horta BL, Ahluwalia TS, Bisgaard H, Bønnelykke K et al. Effect modification of FADS2 polymorphisms on the association between breastfeeding and intelligence: results from a collaborative meta-analysis. Int J Epidemiol. 2019; 48(1):45-57. DOI: 10.1093/ije/dyy273
dc.identifier.issn 0300-5771
dc.identifier.uri http://hdl.handle.net/10230/44059
dc.description.abstract Background: Accumulating evidence suggests that breastfeeding benefits children’s intelligence, possibly due to long-chain polyunsaturated fatty acids (LC-PUFAs) present in breast milk. Under a nutritional adequacy hypothesis, an interaction between breastfeeding and genetic variants associated with endogenous LC-PUFAs synthesis might be expected. However, the literature on this topic is controversial. Methods: We investigated this gene × environment interaction through a collaborative effort. The primary analysis involved >12 000 individuals and used ever breastfeeding, FADS2 polymorphisms rs174575 and rs1535 coded assuming a recessive effect of the G allele, and intelligence quotient (IQ) in Z scores. Results: There was no strong evidence of interaction, with pooled covariate-adjusted interaction coefficients (i.e. difference between genetic groups of the difference in IQ Z scores comparing ever with never breastfed individuals) of 0.12[(95% confidence interval (CI): −0.19; 0.43] and 0.06 (95% CI: −0.16; 0.27) for the rs174575 and rs1535 variants, respectively. Secondary analyses corroborated these results. In studies with ≥5.85 and <5.85 months of breastfeeding duration, pooled estimates for the rs174575 variant were 0.50 (95% CI: −0.06; 1.06) and 0.14 (95% CI: −0.10; 0.38), respectively, and 0.27 (95% CI: −0.28; 0.82) and −0.01 (95% CI: −0.19; 0.16) for the rs1535 variant. Conclusions: Our findings did not support an interaction between ever breastfeeding and FADS2 polymorphisms. However, subgroup analysis suggested that breastfeeding may supply LC-PUFAs requirements for cognitive development if breastfeeding lasts for some (currently unknown) time. Future studies in large individual-level datasets would allow properly powered subgroup analyses and further improve our understanding on the breastfeeding × FADS2 interaction.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Oxford University Press
dc.relation.ispartof Int J Epidemiol. 2019; 48(1):45-57
dc.rights © The Author(s) 2018. Published by Oxford University Press on behalf of the International Epidemiological Association. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Effect modification of FADS2 polymorphisms on the association between breastfeeding and intelligence: results from a collaborative meta-analysis
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1093/ije/dyy273
dc.subject.keyword Breastfeeding
dc.subject.keyword FADS2
dc.subject.keyword Effect modification
dc.subject.keyword Fatty acids
dc.subject.keyword Intelligence
dc.subject.keyword Meta-analysis
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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