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Gender differences in cancer risk after kidney transplantation

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dc.contributor.author Buxeda, Anna
dc.contributor.author Redondo Pachón, María Dolores
dc.contributor.author Pérez-Sáez, María José
dc.contributor.author Bartolomé, Álvaro
dc.contributor.author Mir Fontana, M. Luisa
dc.contributor.author Pascual-Dapena, Ana
dc.contributor.author Sans, Anna
dc.contributor.author Duran Jordà, Xavier, 1974-
dc.contributor.author Crespo Barrio, Marta
dc.contributor.author Pascual Santos, Julio
dc.date.accessioned 2020-03-25T07:50:56Z
dc.date.available 2020-03-25T07:50:56Z
dc.date.issued 2019
dc.identifier.citation Buxeda A, Redondo-Pachón D, Pérez-Sáez MJ, Bartolomé Á, Mir M, Pascual-Dapena A, et al. Gender differences in cancer risk after kidney transplantation. Oncotarget. 2019 May 3; 10(33):3114-28. DOI: 10.18632/oncotarget.26859
dc.identifier.issn 1949-2553
dc.identifier.uri http://hdl.handle.net/10230/44018
dc.description.abstract Kidney transplant (KT) recipients are at greater risk of developing some cancers than the general population. Moreover, cancer is the only cause of death that is currently increasing after kidney transplantation. We analyzed incidence, risk factors and characteristics of post-transplant malignancies (solid organ tumors and lymphoproliferative disorders) at our center in 925 KT recipients (1979-2014). Sex differences were particularly assessed. One hundred and eight patients (11.7%) developed solid organ tumors (76.9%) or lymphoma (23.1%). Twenty-one percent of patients who reached 20 years after KT developed cancer, with a median post-KT time to diagnosis of 7.4 years. Most common solid organs affected were lung (30.1%), prostate (10.8%), bladder (9.6%), and native kidney (7.2%). When analyzing standardized incidence ratios (SIR) by gender compared to the general population, relative risk was increased in women (SIR = 1.81; 95%CI, 1.28-2.45) but not significantly increased in men (SIR = 1.22; 0.95-2.52). Regarding specific types, gynecological (SIR = 11.6; 4.2-22.7) and lung (SIR = 10.0; 4.3-18.2) in women, and bladder (SIR = 16.3; 5.9-32.1) in men were the most affected locations. Thymoglobulin, a polyclonal antibody that has been used as an immunosuppressive agent in kidney transplantation over the last decades, was a significant risk factor for developing cancer in adjusted regression analysis [IRR = 1.62, 1.02-2.57; p = 0.041], and was associated with lower patient survival. Compared with the general population, the incidence of post-KT non-skin cancer is almost two-fold higher in women but not significantly higher in men. Lung is the most common solid organ affected. Thymoglobulin induction therapy is associated with a greater risk.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Impact Journals
dc.relation.ispartof Oncotarget. 2019 May 3;10(33):3114-28
dc.rights © 2019 Buxeda et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), https://creativecommons.org/licenses/by/3.0/ which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.rights.uri https://creativecommons.org/licenses/by/3.0/
dc.title Gender differences in cancer risk after kidney transplantation
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.18632/oncotarget.26859
dc.subject.keyword Cancer
dc.subject.keyword Gender
dc.subject.keyword Immunosuppression
dc.subject.keyword Kidney transplant
dc.subject.keyword Risk factor
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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