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Epigenetic modification of the pentose phosphate pathway and the IGF-axis in women with gestational diabetes mellitus

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dc.contributor.author Steyn, Angela
dc.contributor.author Crowther, Nigel J.
dc.contributor.author Norris, Shane A.
dc.contributor.author Rabionet, Raquel
dc.contributor.author Estivill, Xavier, 1955-
dc.contributor.author Ramsay, Michèle
dc.date.accessioned 2020-03-20T07:46:19Z
dc.date.available 2020-03-20T07:46:19Z
dc.date.issued 2019
dc.identifier.citation Steyn A, Crowther NJ, Norris SA, Rabionet R, Estivill X, Ramsay M. Epigenetic modification of the pentose phosphate pathway and the IGF-axis in women with gestational diabetes mellitus. Epigenomics. 2019; 11(12):1371-85. DOI: 10.2217/epi-2018-0206
dc.identifier.issn 1750-1911
dc.identifier.uri http://hdl.handle.net/10230/43965
dc.description.abstract Aim: Gestational diabetes mellitus (GDM) has been linked with adverse long-term health outcomes for the fetus and mother. These effects may be mediated by epigenetic modifications. Materials & methods: Genome-wide RNA sequencing was performed in placental tissue and maternal blood in six GDM and six non-GDM pregnancies. Promoter region DNA methylation was examined for selected genes and correlated with gene expression to examine an epigenetic modulator mechanism. Results: Reductions of mRNA expression and increases in promoter methylation were observed for G6PD in GDM women, and for genes encoding IGF-binding proteins in GDM-exposed placenta. Conclusion: GDM involves epigenetic attenuation of G6PD, which may lead to hyperglycemia and oxidative stress, and the IGF-axis, which may modulate fetal macrosomia.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Future Medicine
dc.relation.ispartof Epigenomics. 2019; 11(12):1371-85
dc.rights © 2019 University of the Witwatersrand. Open access. This work is licensed under the Attribution-NonCommercial-NoDerivatives 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.title Epigenetic modification of the pentose phosphate pathway and the IGF-axis in women with gestational diabetes mellitus
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.2217/epi-2018-0206
dc.subject.keyword DNA methylation
dc.subject.keyword IGF binding protein
dc.subject.keyword RNA sequencing
dc.subject.keyword Epigenetics
dc.subject.keyword Gestational diabetes mellitus
dc.subject.keyword Glucose-6-phosphate dehydrogenase
dc.subject.keyword Pentose phosphate pathway
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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